microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR556 Gene

Subcategory (RNA class) for MIR556 Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR556 Gene

  • MIMAT0003220 50
  • MIMAT0004793 50
  • MI0003562 50
  • MIRN556 3
  • Mir-556 3
  • RF00969 168

External Ids for MIR556 Gene

Previous HGNC Symbols for MIR556 Gene

  • MIRN556

Previous GeneCards Identifiers for MIR556 Gene

  • GC01P160579
  • GC01P162312

Summaries for MIR556 Gene

Entrez Gene Summary for MIR556 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR556 Gene

MIR556 (MicroRNA 556) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR556 include Clear Cell Renal Cell Carcinoma.

Rfam classification for MIR556 Gene

Additional gene information for MIR556 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR556 Gene

Genomics for MIR556 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR556 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J162343 Enhancer 0.4 Ensembl 600.7 +1.5 1455 2 SCRT1 SPI1 MEIS2 MIR556 piR-61532-022 ENSG00000272574 ENSG00000254706 NOS1AP
GH01J162388 Enhancer 1.2 Ensembl ENCODE 10.8 +47.0 46958 7.3 CTCF REST ZNF512 LEF1 IKZF1 ETV6 JUND DDX20 MTA2 PHF21A DUSP12 MIR556 ENSG00000215840 SLAMF6P1 UHMK1 C1orf226 RGS4 lnc-SH2D1B-2 SH2D1B
GH01J162065 Enhancer 0.7 Ensembl ENCODE 10.2 -277.1 -277127 0.8 CTCF ZNF692 RAD21 PRDM4 ZFP69B NFIL3 SNIP1 ZNF362 ZNF384 SMC3 RF00017-374 C1orf226 DEDD USP21 ENSG00000215840 B4GALT3 SH2D1B DUSP12 MIR556 SPATA46
GH01J162292 Enhancer 0.5 Ensembl 11.4 -49.0 -49045 3 PRDM10 RFX1 BMI1 CEBPB NFIC NFIB ZNF366 JUN C1orf226 ENSG00000227094 MIR556 SPATA46 NOS1AP piR-32559-024 piR-38562-006 ENSG00000254706
GH01J162028 Enhancer 0.4 FANTOM5 9.5 -313.7 -313693 0.4 RELA SPI1 ETV6 MIR556 C1orf226 SPATA46 ATF6 OLFML2B ENSG00000227818 NOS1AP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR556 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR556 Gene

Genomic Locations for MIR556 Gene
chr1:162,342,546-162,342,640
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand
chr1:162,312,336-162,312,430
(GRCh37/hg19)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR556 Gene

Genes around MIR556 on UCSC Golden Path with GeneCards custom track
MIR556 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR556 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR556 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR556 Gene

Proteins for MIR556 Gene

Post-translational modifications for MIR556 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR556 Gene

Domains & Families for MIR556 Gene

Gene Families for MIR556 Gene

HGNC:
genes like me logo Genes that share domains with MIR556: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR556 Gene

Function for MIR556 Gene

Phenotypes From GWAS Catalog for MIR556 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR556 Gene

Localization for MIR556 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR556 Gene

Pathways & Interactions for MIR556 Gene

PathCards logo

SuperPathways for MIR556 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR556 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR556: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR556 Gene

Drugs & Compounds for MIR556 Gene

No Compound Related Data Available

Transcripts for MIR556 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR556 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006C3A3C_9606 precursor_RNA 95 6

HGNC: 32812,

RefSeq: NR_030283,

Ensembl: ENST00000384996 (view in UCSC) ,

miRBase: MI0003562,

Rfam: RF00969,

ENA: LM609549.1:1..95:precursor_RNA,

URS00001D6605_9606 miRNA 22 5

RefSeq: NR_030283,

LncBase: hsa-miR-556-3p,

miRBase: MIMAT0004793,

TarBase: hsa-miR-556-3p,

ENA: LM380404.1:1..22:ncRNA, LM609549.1:55..76:ncRNA,

URS000033CC69_9606 miRNA 22 5

RefSeq: NR_030283,

LncBase: hsa-miR-556-5p,

miRBase: MIMAT0003220,

TarBase: hsa-miR-556-5p,

ENA: LM379855.1:1..22:ncRNA, LM609549.1:16..37:ncRNA,

URS0000EFE3B6_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-556,

URS0000D55446_9606 miRNA 21 1

MirGeneDB: Hsa-Mir-556_5p,

MIR556 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR556 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR556 Gene

No ASD Table

Relevant External Links for MIR556 Gene

GeneLoc Exon Structure for
MIR556

Expression for MIR556 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR556 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR556

genes like me logo Genes that share expression patterns with MIR556: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR556 Gene

Orthologs for MIR556 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR556 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-556 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR556 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR556 Gene

ENSEMBL:
Gene Tree for MIR556 (if available)
TreeFam:
Gene Tree for MIR556 (if available)

Paralogs for MIR556 Gene

No data available for Paralogs for MIR556 Gene

Variants for MIR556 Gene

Additional dbSNP identifiers (rs#s) for MIR556 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR556 Gene

Variant ID Type Subtype PubMed ID
esv2758973 CNV gain 17122850
esv34209 CNV gain 17911159
esv3587740 CNV gain 21293372
nsv516482 CNV gain+loss 19592680
nsv818511 CNV gain 17921354

Additional Variant Information for MIR556 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR556

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR556 Gene

Disorders for MIR556 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR556 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
clear cell renal cell carcinoma
  • clear cell carcinoma of kidney
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR556

genes like me logo Genes that share disorders with MIR556: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR556 Gene

Publications for MIR556 Gene

  1. MicroRNA-556-3p promotes the progression of esophageal cancer via targeting DAB2IP. (PMID: 30402845) Lu HB (European review for medical and pharmacological sciences 2018) 3
  2. A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding. (PMID: 29569387) Wang Y … Shen ZY (Journal of cellular and molecular medicine 2018) 3
  3. miRNA-556-3p promotes human bladder cancer proliferation, migration and invasion by negatively regulating DAB2IP expression. (PMID: 28440444) Feng C … Feng Y (International journal of oncology 2017) 3
  4. High-Throughput Sequencing Reveals Circulating miRNAs as Potential Biomarkers of Kidney Damage in Patients with Systemic Lupus Erythematosus. (PMID: 27835701) Navarro-Quiroz E … Aroca G (PloS one 2016) 3
  5. Upregulation of miR-556-5p promoted prostate cancer cell proliferation by suppressing PPP2R2A expression. (PMID: 26297546) Zhao W … Men T (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015) 3

Products for MIR556 Gene

Sources for MIR556 Gene