microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR552 Gene

Subcategory (RNA class) for MIR552 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR552 Gene

  • MicroRNA 552 2 3 5
  • Hsa-MiR-552-3p 177
  • MIMAT0026615 51
  • MIMAT0003215 51
  • Hsa-Mir-552 3
  • MI0003557 51
  • MIRN552 3
  • RF00990 172
  • MIR552 2

External Ids for MIR552 Gene

Previous HGNC Symbols for MIR552 Gene

  • MIRN552

Previous GeneCards Identifiers for MIR552 Gene

  • GC01M034908
  • GC01M035135

Summaries for MIR552 Gene

Entrez Gene Summary for MIR552 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR552 Gene

MIR552 (MicroRNA 552) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR552 Gene

Additional gene information for MIR552 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR552 Gene

Genomics for MIR552 Gene

GeneHancer (GH) Regulatory Elements for MIR552 Gene

Promoters and enhancers for MIR552 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J034590 Enhancer 0.8 Ensembl ENCODE 10.2 +79.4 79393 1 EP300 ZIC2 RFX1 NFIC SMC3 TCF12 BATF NFIB SIN3A JUN MIR552 MG828668-001 lnc-SMIM12-1 LOC105378641
GH01J034616 Enhancer 0.6 Ensembl ENCODE 10.7 +51.2 51218 3 CEBPG CEBPB ATF2 HLF ZNF24 ATF7 lnc-SMIM12-1 MIR552 lnc-GJB5-2 LOC105378641
GH01J034613 Enhancer 0.2 Ensembl 10.6 +59.0 58993 0.2 MIR552 lnc-SMIM12-1 MG828668-001 LOC105378641
GH01J034612 Enhancer 0.2 Ensembl 10.6 +57.2 57193 0.2 MIR552 lnc-SMIM12-1 MG828668-001 LOC105378641
GH01J034470 Enhancer 0.2 Ensembl 10.1 +199.0 198993 0.2 MIR552 piR-38051-002 LOC105378640 LOC105378641
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR552 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR552 Gene

Genomic Locations for MIR552 Gene
chr1:34,669,599-34,669,694
(GRCh38/hg38)
Size:
96 bases
Orientation:
Minus strand
chr1:35,135,200-35,135,295
(GRCh37/hg19)
Size:
96 bases
Orientation:
Minus strand

Genomic View for MIR552 Gene

Genes around MIR552 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR552 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR552 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR552 Gene

Proteins for MIR552 Gene

Post-translational modifications for MIR552 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR552 Gene

Domains & Families for MIR552 Gene

Gene Families for MIR552 Gene

HGNC:
genes like me logo Genes that share domains with MIR552: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR552 Gene

Function for MIR552 Gene

Phenotypes From GWAS Catalog for MIR552 Gene

Gene Ontology (GO) - Molecular Function for MIR552 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28397307
genes like me logo Genes that share ontologies with MIR552: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR552 Gene

Localization for MIR552 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR552 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR552 Gene

Pathways & Interactions for MIR552 Gene

PathCards logo

SuperPathways for MIR552 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR552 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 28397307
genes like me logo Genes that share ontologies with MIR552: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR552 Gene

Drugs & Compounds for MIR552 Gene

No Compound Related Data Available

Transcripts for MIR552 Gene

mRNA/cDNA for MIR552 Gene

4 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
1 ENA transcripts :
1 Rfam transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR552 Gene

No ASD Table

Relevant External Links for MIR552 Gene

GeneLoc Exon Structure for
MIR552

Expression for MIR552 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR552 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR552

genes like me logo Genes that share expression patterns with MIR552: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR552 Gene

Orthologs for MIR552 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR552 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-552 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR552 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR552 Gene

ENSEMBL:
Gene Tree for MIR552 (if available)
TreeFam:
Gene Tree for MIR552 (if available)

Paralogs for MIR552 Gene

No data available for Paralogs for MIR552 Gene

Variants for MIR552 Gene

Additional dbSNP identifiers (rs#s) for MIR552 Gene

Additional Variant Information for MIR552 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR552

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR552 Gene

Disorders for MIR552 Gene

Additional Disease Information for MIR552

No disorders were found for MIR552 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR552 Gene

Publications for MIR552 Gene

  1. MicroRNA-552 promotes migration and invasion of osteosarcoma through targeting TIMP2. (PMID: 30765222) Chao Y … Wang L (Biochemical and biophysical research communications 2019) 3 54
  2. MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1. (PMID: 30221686) Li C … Liu C (International journal of molecular medicine 2018) 3 54
  3. MicroRNA-552 links Wnt signaling to p53 tumor suppressor in colorectal cancer. (PMID: 30066856) Kwak B … Kim SW (International journal of oncology 2018) 3 54
  4. Genetic variants in microRNAs and their binding sites within gene 3'UTRs associate with susceptibility to age-related macular degeneration. (PMID: 28397307) Ghanbari M … Meester-Smoor MA (Human mutation 2017) 3 54
  5. MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28. (PMID: 27661126) Wang J … Yang Y (Oncotarget 2016) 3 54

Products for MIR552 Gene

Sources for MIR552 Gene