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Aliases for MIR552 Gene

Subcategory (RNA class) for MIR552 Gene


Quality Score for this RNA gene is


Aliases for MIR552 Gene

  • MicroRNA 552 2 3 5
  • Hsa-Mir-552 3
  • MIRN552 3

External Ids for MIR552 Gene

Previous HGNC Symbols for MIR552 Gene

  • MIRN552

Previous GeneCards Identifiers for MIR552 Gene

  • GC01M034908
  • GC01M035135

Summaries for MIR552 Gene

Entrez Gene Summary for MIR552 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR552 Gene

MIR552 (MicroRNA 552) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR552 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR552

Additional gene information for MIR552 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR552 Gene

Genomics for MIR552 Gene

GeneHancer (GH) Regulatory Elements for MIR552 Gene

Promoters and enhancers for MIR552 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J034590 Enhancer 0.6 ENCODE 10.2 +79.3 79299 0.4 RFX1 NFIA NFIB SIN3A BMI1 BATF ZIC2 NFIC POLR2A RFX3 MIR552 GC01P034566 GC01M034670 LOC105378641
GH01J034616 Enhancer 0.5 ENCODE 10.7 +51.2 51218 3 HLF CEBPB ATF7 CEBPG ATF2 MIR552 GC01M034670 GC01P034566 LOC105378641
GH01J034682 Enhancer 0.7 ENCODE 0.4 -14.3 -14345 3.9 CTCF SOX13 FOXA2 MAX CEBPG RARA NR2F6 GATAD2A SOX5 RFX1 GJB4 LOC105378641 MIR552
GH01J034681 Enhancer 0.6 ENCODE 0.4 -12.0 -12045 0 CTCF ZNF654 CEBPB TRIM22 CEBPG REST RAD21 XRCC5 ZNF143 SMC3 GJB4 LOC105378641 MIR552
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR552 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR552 Gene

Genomic Locations for MIR552 Gene
96 bases
Minus strand
96 bases
Minus strand

Genomic View for MIR552 Gene

Genes around MIR552 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR552 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR552 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR552 Gene

ORGUL Member Location for MIR552 Gene

ORGUL Member Location for MIR552 gene

Proteins for MIR552 Gene

Post-translational modifications for MIR552 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR552 Gene

Domains & Families for MIR552 Gene

Gene Families for MIR552 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR552: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR552 Gene

Function for MIR552 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR552 Gene

Localization for MIR552 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR552 Gene

Pathways & Interactions for MIR552 Gene

SuperPathways for MIR552 Gene

No Data Available

Interacting Proteins for MIR552 Gene

Gene Ontology (GO) - Biological Process for MIR552 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR552 Gene

Drugs & Compounds for MIR552 Gene

No Compound Related Data Available

Transcripts for MIR552 Gene

fRNAdb Secondary structures for MIR552 Gene

  • hsa-mir-552_MI0003557_Homo_sapiens_miR-552_stem-loop_hairpin

mRNA/cDNA for MIR552 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR552 Gene

No ASD Table

Relevant External Links for MIR552 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR552 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR552 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR552 Gene:

genes like me logo Genes that share expression patterns with MIR552: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR552 Gene

Orthologs for MIR552 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR552 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-552 34
  • 100 (a)
Species where no ortholog for MIR552 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR552 Gene

Gene Tree for MIR552 (if available)
Gene Tree for MIR552 (if available)

Paralogs for MIR552 Gene

No data available for Paralogs for MIR552 Gene

Variants for MIR552 Gene

Sequence variations from dbSNP and Humsavar for MIR552 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000422665 -- 34,670,730(-) A/G upstream_transcript_variant
rs1000560859 -- 34,670,038(-) T/C upstream_transcript_variant
rs1001310871 -- 34,670,615(-) TTTTTTT/TTTTTT upstream_transcript_variant
rs1004029984 -- 34,669,452(-) A/G downstream_transcript_variant
rs1007823894 -- 34,671,675(-) G/A upstream_transcript_variant

Additional Variant Information for MIR552 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR552 Gene

Disorders for MIR552 Gene

Additional Disease Information for MIR552

No disorders were found for MIR552 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR552 Gene

Publications for MIR552 Gene

  1. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 1 3 58
  2. A dual inhibition: microRNA-552 suppresses both transcription and translation of cytochrome P450 2E1. (PMID: 26926595) Miao L … Wang Y (Biochimica et biophysica acta 2016) 3 58
  3. MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28. (PMID: 27661126) Wang J … Yang Y (Oncotarget 2016) 3 58
  4. MiR-5000-3p, miR-5009-3P and miR-552: potential microRNA biomarkers of side population cells in colon cancer. (PMID: 24898979) Xia ZS … Chen GC (Oncology reports 2014) 3 58
  5. miR-592 and miR-552 can distinguish between primary lung adenocarcinoma and colorectal cancer metastases in the lung. (PMID: 24778034) Kim J … Lee GK (Anticancer research 2014) 3 58

Products for MIR552 Gene

Sources for MIR552 Gene

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