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Aliases for MIR551B Gene

Subcategory (RNA class) for MIR551B Gene


Quality Score for this RNA gene is


Aliases for MIR551B Gene

  • MicroRNA 551b 2 3 5
  • Hsa-Mir-551b 3
  • Mir-551b 3
  • MIRN551B 3

External Ids for MIR551B Gene

ORGUL Members for MIR551B Gene

Previous HGNC Symbols for MIR551B Gene

  • MIRN551B

Previous GeneCards Identifiers for MIR551B Gene

  • GC03P169753
  • GC03P168269

Summaries for MIR551B Gene

Entrez Gene Summary for MIR551B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR551B Gene

MIR551B (MicroRNA 551b) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR551B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR551B Gene

Genomics for MIR551B Gene

Genomic Locations for MIR551B Gene

Genomic Locations for MIR551B Gene
96 bases
Plus strand

Genomic View for MIR551B Gene

Genes around MIR551B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR551B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR551B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR551B Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR551B Gene

Proteins for MIR551B Gene

Post-translational modifications for MIR551B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR551B Gene

Domains & Families for MIR551B Gene

Gene Families for MIR551B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR551B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR551B Gene

Function for MIR551B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR551B Gene

Localization for MIR551B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR551B Gene

Pathways & Interactions for MIR551B Gene

SuperPathways for MIR551B Gene

No Data Available

Interacting Proteins for MIR551B Gene

Gene Ontology (GO) - Biological Process for MIR551B Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR551B Gene

Drugs & Compounds for MIR551B Gene

No Compound Related Data Available

Transcripts for MIR551B Gene

mRNA/cDNA for MIR551B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR551B Gene

No ASD Table

Relevant External Links for MIR551B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR551B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR551B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR551B Gene:

genes like me logo Genes that share expression patterns with MIR551B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR551B Gene

Orthologs for MIR551B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR551B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-551b 34
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-551b 34
  • 96 (a)
(Bos Taurus)
Mammalia bta-mir-551b 34
  • 93 (a)
(Mus musculus)
Mammalia Mir551b 34
  • 86 (a)
(Monodelphis domestica)
Mammalia mdo-mir-551b 34
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-551 34
  • 76 (a)
(Gallus gallus)
Aves gga-mir-551 34
  • 62 (a)
(Anolis carolinensis)
Reptilia aca-mir-551 34
  • 73 (a)
Species where no ortholog for MIR551B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR551B Gene

Gene Tree for MIR551B (if available)
Gene Tree for MIR551B (if available)

Paralogs for MIR551B Gene

No data available for Paralogs for MIR551B Gene

Variants for MIR551B Gene

Sequence variations from dbSNP and Humsavar for MIR551B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000553790 -- 168,550,177(+) G/C upstream_transcript_variant
rs1000740685 -- 168,549,857(+) A/G upstream_transcript_variant
rs1002515210 -- 168,550,563(+) G/A upstream_transcript_variant
rs1003786085 -- 168,551,862(+) T/C non_coding_transcript_variant
rs1004223451 -- 168,552,102(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR551B Gene

Variant ID Type Subtype PubMed ID
nsv829788 CNV loss 17160897
nsv829789 CNV gain 17160897

Additional Variant Information for MIR551B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR551B Gene

Disorders for MIR551B Gene

Additional Disease Information for MIR551B

No disorders were found for MIR551B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR551B Gene

Publications for MIR551B Gene

  1. MicroRNA-551b is highly expressed in hematopoietic stem cells and a biomarker for relapse and poor prognosis in acute myeloid leukemia. (PMID: 26108690) de Leeuw DC … Smit L (Leukemia 2016) 3 58
  2. Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer. (PMID: 27743201) Wei Z … Yu X (Medical oncology (Northwood, London, England) 2016) 3 58
  3. Serum levels of unique miR-551-5p and endothelial-specific miR-126a-5p allow discrimination of patients in the early phase of acute pancreatitis. (PMID: 26094040) Kuśnierz-Cabala B … Stępień E (Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015) 3 58
  4. A signaling pathway consisting of miR-551b, catalase and MUC1 contributes to acquired apoptosis resistance and chemoresistance. (PMID: 25085901) Xu X … Lin Y (Carcinogenesis 2014) 3 58
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58

Products for MIR551B Gene

Sources for MIR551B Gene

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