microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548Z Gene

Subcategory (RNA class) for MIR548Z Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR548Z Gene

  • MicroRNA 548z 2 3 5
  • Hsa-MiR-548h-3p 166 177
  • Hsa-MiR-548z 166 177
  • Hsa-Mir-548z 3
  • MIMAT0018446 51
  • MIMAT0022723 51
  • MI0016688 51
  • MIR548Z 2

External Ids for MIR548Z Gene

Previous GeneCards Identifiers for MIR548Z Gene

  • GC12U901505
  • GC12M065017

Summaries for MIR548Z Gene

Entrez Gene Summary for MIR548Z Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548Z Gene

MIR548Z (MicroRNA 548z) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR548Z Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548Z Gene

Genomics for MIR548Z Gene

GeneHancer (GH) Regulatory Elements for MIR548Z Gene

Promoters and enhancers for MIR548Z Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J064618 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 -1.0 -1020 10.1 ZBTB40 ZNF217 TCF12 USF1 POLR2G JUND FOS EP300 CLOCK ZBTB11 MIR548C MIR548Z TBK1 RASSF3 ENSG00000256293 GNS ENSG00000225195
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548Z on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR548Z Gene

Genomic Locations for MIR548Z Gene
chr12:64,622,509-64,622,605
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand
chr12:65,016,289-65,016,385
(GRCh37/hg19)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR548Z Gene

Genes around MIR548Z on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548Z Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548Z Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548Z Gene

Proteins for MIR548Z Gene

Post-translational modifications for MIR548Z Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548Z Gene

Domains & Families for MIR548Z Gene

Gene Families for MIR548Z Gene

genes like me logo Genes that share domains with MIR548Z: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548Z Gene

Function for MIR548Z Gene

Phenotypes From GWAS Catalog for MIR548Z Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548Z Gene

Localization for MIR548Z Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548Z Gene

Pathways & Interactions for MIR548Z Gene

PathCards logo

SuperPathways for MIR548Z Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR548Z Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR548Z Gene

Drugs & Compounds for MIR548Z Gene

No Compound Related Data Available

Transcripts for MIR548Z Gene

mRNA/cDNA for MIR548Z Gene

2 RNACentral transcripts :
2 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
5 ENA transcripts :
2 LncBase transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548Z Gene

No ASD Table

Relevant External Links for MIR548Z Gene

GeneLoc Exon Structure for
MIR548Z

Expression for MIR548Z Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR548Z

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548Z Gene

Orthologs for MIR548Z Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548Z Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 80 (a)
ManyToMany
Species where no ortholog for MIR548Z was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548Z Gene

ENSEMBL:
Gene Tree for MIR548Z (if available)
TreeFam:
Gene Tree for MIR548Z (if available)

Paralogs for MIR548Z Gene

No data available for Paralogs for MIR548Z Gene

Variants for MIR548Z Gene

Additional dbSNP identifiers (rs#s) for MIR548Z Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR548Z Gene

Variant ID Type Subtype PubMed ID
dgv2682n54 CNV gain 21841781
nsv832443 CNV loss 17160897
nsv832444 CNV loss 17160897

Additional Variant Information for MIR548Z Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548Z

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR548Z Gene

Disorders for MIR548Z Gene

Additional Disease Information for MIR548Z

No disorders were found for MIR548Z Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548Z Gene

Publications for MIR548Z Gene

  1. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D … Lui WO (BMC biology 2010) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR548Z Gene

Sources for MIR548Z Gene