microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548L Gene

Subcategory (RNA class) for MIR548L Gene


Quality Score for this RNA gene is


Aliases for MIR548L Gene

  • MicroRNA 548l 2 3 5
  • Hsa-MiR-548l 168 179
  • Hsa-Mir-548l 3
  • MIMAT0005889 53
  • MI0006361 53
  • MIRN548L 3
  • MIR548L 2

External Ids for MIR548L Gene

Previous HGNC Symbols for MIR548L Gene

  • MIRN548L

Previous GeneCards Identifiers for MIR548L Gene

  • GC00U922821
  • GC11M093840
  • GC11M094199

Summaries for MIR548L Gene

Entrez Gene Summary for MIR548L Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548L Gene

MIR548L (MicroRNA 548l) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR548L include Ataxia-Telangiectasia-Like Disorder 1.

Additional gene information for MIR548L Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548L Gene

Genomics for MIR548L Gene

GeneHancer (GH) Regulatory Elements for MIR548L Gene

Promoters and enhancers for MIR548L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J094423 Enhancer 0.3 Ensembl 11.9 +42.2 42156 1.2 JUND MRE11 MIR548L GPR83 ENSG00000255893 ANKRD49 HSALNG0086516 lnc-GPR83-3
GH11J094426 Enhancer 0.2 Ensembl 11.6 +40.5 40479 0.2 GPR83 MIR548L ENSG00000255893 PANX1 HSALNG0086516 lnc-GPR83-3 MRE11
GH11J094448 Enhancer 0.9 Ensembl ENCODE 0.4 +17.0 16979 2.4 SIN3A SREBF1 MNT SP1 MAFK CEBPG CEBPA PRDM10 FOXA2 CEBPB MRE11 ANKRD49 ENSG00000255893 lnc-GPR83-3 MIR548L
GH11J094457 Enhancer 0.7 Ensembl 0.4 +9.0 8979 1.2 MAFK BACH1 SMARCA4 IKZF1 NFE2L2 PKNOX1 HDAC1 ZNF316 NFE2 LEF1 MRE11 MIR548L lnc-GPR83-3
GH11J094456 Enhancer 0.4 Ensembl 0.4 +10.3 10279 0.2 CTBP1 RFX1 JUND lnc-GPR83-3 MIR548L MRE11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548L on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR548L Gene

Genomic Locations for MIR548L Gene
86 bases
Minus strand
86 bases
Minus strand

Genomic View for MIR548L Gene

Genes around MIR548L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548L Gene

Proteins for MIR548L Gene

Post-translational modifications for MIR548L Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548L Gene

Domains & Families for MIR548L Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548L Gene

Function for MIR548L Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548L Gene

Localization for MIR548L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548L Gene

Pathways & Interactions for MIR548L Gene

PathCards logo

SuperPathways for MIR548L Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR548L Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR548L Gene

Drugs & Compounds for MIR548L Gene

No Compound Related Data Available

Transcripts for MIR548L Gene

mRNA/cDNA for MIR548L Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(3) ENA transcripts :
(1) TarBase transcripts :
(1) LncBase transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548L Gene

No ASD Table

Relevant External Links for MIR548L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR548L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR548L Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR548L Gene:

genes like me logo Genes that share expression patterns with MIR548L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548L Gene

Orthologs for MIR548L Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-548l 33
  • 99 (a)
Species where no ortholog for MIR548L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548L Gene

Gene Tree for MIR548L (if available)
Gene Tree for MIR548L (if available)

Paralogs for MIR548L Gene

No data available for Paralogs for MIR548L Gene

Variants for MIR548L Gene

Sequence variations from dbSNP and Humsavar for MIR548L Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs11020793 benign, Hereditary cancer-predisposing syndrome, not specified, Ataxia-telangiectasia-like disorder 1, not provided 94,467,879(-) A/C upstream_transcript_variant
rs140067184 other, Bladder cancer, somatic 94,467,199(-) G/A upstream_transcript_variant
rs140528613 uncertain-significance, Ataxia-telangiectasia-like disorder 1, Hereditary cancer-predisposing syndrome 94,467,820(-) C/A/T upstream_transcript_variant
rs1430351329 uncertain-significance, Hereditary cancer-predisposing syndrome, Ataxia-telangiectasia-like disorder 1 94,467,838(-) G/T upstream_transcript_variant
rs1555011987 likely-benign, Hereditary cancer-predisposing syndrome 94,467,813(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR548L Gene

Variant ID Type Subtype PubMed ID
esv2671948 CNV deletion 23128226

Additional Variant Information for MIR548L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548L Gene

Disorders for MIR548L Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR548L Gene - From: GeneCards

Disorder Aliases PubMed IDs
ataxia-telangiectasia-like disorder 1
  • atld1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR548L

genes like me logo Genes that share disorders with MIR548L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR548L Gene

Publications for MIR548L Gene

  1. MiRNA expression profiles reveal the involvement of miR-26a, miR-548l and miR-34a in hepatocellular carcinoma progression through regulation of ST3GAL5. (PMID: 28218742) Cai H … Jia L (Laboratory investigation; a journal of technical methods and pathology 2017) 3 56
  2. microRNA-548l is involved in the migration and invasion of non-small cell lung cancer by targeting the AKT1 signaling pathway. (PMID: 25245053) Liu C … Zhou R (Journal of cancer research and clinical oncology 2015) 3 56
  3. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 56
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR548L Gene

Sources for MIR548L Gene