microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548H2 Gene

Subcategory (RNA class) for MIR548H2 Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR548H2 Gene

  • MicroRNA 548h-2 2 3 5
  • Hsa-MiR-548h-5p 168 179
  • Hsa-Mir-548h-2 3
  • MIMAT0005928 53
  • MIR548H-2 3
  • MIRN548H2 3
  • MI0006412 53
  • MIR548H2 2

External Ids for MIR548H2 Gene

Previous HGNC Symbols for MIR548H2 Gene

  • MIRN548H2

Previous GeneCards Identifiers for MIR548H2 Gene

  • GC00U923033
  • GC16M011308
  • GC16M011400

Summaries for MIR548H2 Gene

Entrez Gene Summary for MIR548H2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548H2 Gene

MIR548H2 (MicroRNA 548h-2) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR548H2 Gene

Additional gene information for MIR548H2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR548H2 Gene

Genomics for MIR548H2 Gene

GeneHancer (GH) Regulatory Elements for MIR548H2 Gene

Promoters and enhancers for MIR548H2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J011306 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -5.4 -5361 10.7 ZNF24 SP1 ZBTB40 LCORL MLX RBPJ TCF7L2 NR2F1 NR2F6 ATF1 RMI2 NUBP1 GSPT1 COX6CP1 ENSG00000263307 CIITA ENSG00000263080 SOCS1 ENSG00000199668 RF01061-066
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548H2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR548H2 Gene

Genomic Locations for MIR548H2 Gene
chr16:11,306,440-11,306,527
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr16:11,400,297-11,400,384
(GRCh37/hg19)
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR548H2 Gene

Genes around MIR548H2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548H2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548H2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548H2 Gene

Proteins for MIR548H2 Gene

Post-translational modifications for MIR548H2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548H2 Gene

Domains & Families for MIR548H2 Gene

Gene Families for MIR548H2 Gene

genes like me logo Genes that share domains with MIR548H2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548H2 Gene

Function for MIR548H2 Gene

Phenotypes From GWAS Catalog for MIR548H2 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548H2 Gene

Localization for MIR548H2 Gene

Gene Ontology (GO) - Cellular Components for MIR548H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR548H2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR548H2 Gene

Pathways & Interactions for MIR548H2 Gene

PathCards logo

SuperPathways for MIR548H2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR548H2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR548H2: view

No data available for Pathways by source and SIGNOR curated interactions for MIR548H2 Gene

Drugs & Compounds for MIR548H2 Gene

No Compound Related Data Available

Transcripts for MIR548H2 Gene

mRNA/cDNA for MIR548H2 Gene

(5) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(2) RNACentral transcripts :
(1) TarBase transcripts :
(7) ENA transcripts :
(1) LncBase transcripts :
(2) miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548H2 Gene

No ASD Table

Relevant External Links for MIR548H2 Gene

GeneLoc Exon Structure for
MIR548H2
ECgene alternative splicing isoforms for
MIR548H2

Expression for MIR548H2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR548H2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR548H2 Gene:

MIR548H2
genes like me logo Genes that share expression patterns with MIR548H2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548H2 Gene

Orthologs for MIR548H2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548H2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 33
  • 99 (a)
OneToOne
Species where no ortholog for MIR548H2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548H2 Gene

ENSEMBL:
Gene Tree for MIR548H2 (if available)
TreeFam:
Gene Tree for MIR548H2 (if available)

Paralogs for MIR548H2 Gene

No data available for Paralogs for MIR548H2 Gene

Variants for MIR548H2 Gene

Sequence variations from dbSNP and Humsavar for MIR548H2 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000750373 -- 11,307,420(-) GGGG/GGG upstream_transcript_variant
rs1000913627 -- 11,306,707(-) C/G upstream_transcript_variant
rs1000965353 -- 11,306,498(-) A/G non_coding_transcript_variant
rs1002424602 -- 11,306,551(-) G/C upstream_transcript_variant
rs1002964638 -- 11,308,289(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR548H2 Gene

Variant ID Type Subtype PubMed ID
nsv1040428 CNV gain 25217958
nsv571454 CNV loss 21841781

Additional Variant Information for MIR548H2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548H2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR548H2 Gene

Disorders for MIR548H2 Gene

Additional Disease Information for MIR548H2

No disorders were found for MIR548H2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548H2 Gene

Publications for MIR548H2 Gene

  1. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3 56
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 56

Products for MIR548H2 Gene

Sources for MIR548H2 Gene