microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548E Gene

Subcategory (RNA class) for MIR548E Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR548E Gene

  • MicroRNA 548e 2 3 5
  • Hsa-MiR-548e-3p 163 173
  • Hsa-Mir-548e 2 3
  • MIR548E 2 5
  • Hsa-MiR-548e-5p 163
  • MIMAT0005874 50
  • MIMAT0026736 50
  • MI0006344 50
  • MIRN548E 3

External Ids for MIR548E Gene

Previous HGNC Symbols for MIR548E Gene

  • MIRN548E

Previous GeneCards Identifiers for MIR548E Gene

  • GC00U923163
  • GC10P112739

Summaries for MIR548E Gene

Entrez Gene Summary for MIR548E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548E Gene

MIR548E (MicroRNA 548e) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR548E Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548E Gene

Genomics for MIR548E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR548E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J110987 Enhancer 0.2 Ensembl 600.7 -1.3 -1325 0.8 MIR548E RPL13AP6 SHOC2 ADRA2A
GH10J110965 Enhancer 0.7 Ensembl 0.4 -24.0 -24025 9 PRDM1 SP1 CEBPB ZNF316 YY1 ZKSCAN1 BCOR JUNB BATF ZNF366 SHOC2 ADRA2A BBIP1 ENSG00000270589 MIR548E RPL13AP6
GH10J110943 Promoter/Enhancer 0.8 EPDnew Ensembl 0.3 -43.7 -43725 5.2 FOXA1 SCRT1 POLR2A MYC ZNF133 SHOC2 BBIP1 ADRA2A ENSG00000270589 RPL13AP6 MIR548E
GH10J110977 Enhancer 0.5 Ensembl 0.4 -11.0 -11026 1.8 ZNF580 HNF4A ZNF843 FEZF1 PRDM6 BBIP1 SHOC2 ENSG00000232470 PDCD4 MIR548E RPL13AP6 ADRA2A
GH10J110972 Enhancer 0.5 Ensembl 0.4 -16.3 -16325 6 CEBPB ZNF316 CEBPG FEZF1 PRDM6 ZBTB33 MZF1 ADRA2A SHOC2 BBIP1 PDCD4 ENSG00000232470 MIR548E RPL13AP6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548E on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR548E Gene

Genomic Locations for MIR548E Gene
chr10:110,988,926-110,989,013
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand
chr10:112,748,684-112,748,771
(GRCh37/hg19)
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR548E Gene

Genes around MIR548E on UCSC Golden Path with GeneCards custom track
MIR548E in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR548E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548E Gene

Proteins for MIR548E Gene

Post-translational modifications for MIR548E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548E Gene

Domains & Families for MIR548E Gene

Gene Families for MIR548E Gene

genes like me logo Genes that share domains with MIR548E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548E Gene

Function for MIR548E Gene

Phenotypes From GWAS Catalog for MIR548E Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548E Gene

Localization for MIR548E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR548E gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548E Gene

Pathways & Interactions for MIR548E Gene

PathCards logo

SuperPathways for MIR548E Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR548E Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR548E Gene

Drugs & Compounds for MIR548E Gene

No Compound Related Data Available

Transcripts for MIR548E Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR548E Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000759FC7_9606 precursor_RNA 88 5

HGNC: 35275,

RefSeq: NR_031614,

Ensembl: ENST00000408287 (view in UCSC) ,

miRBase: MI0006344,

ENA: LM610109.1:1..88:precursor_RNA,

URS00000D2680_9606 miRNA 22 5

RefSeq: NR_031614,

LncBase: hsa-miR-548e-3p,

miRBase: MIMAT0005874,

TarBase: hsa-miR-548e-3p,

ENA: LM380674.1:1..22:ncRNA, LM610109.1:53..74:ncRNA,

URS000077B07D_9606 miRNA 22 4

RefSeq: NR_031614,

LncBase: hsa-miR-548e-5p,

miRBase: MIMAT0026736,

ENA: LM383203.1:1..22:ncRNA, LM610109.1:15..36:ncRNA,

MIR548E in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548E Gene

No ASD Table

Relevant External Links for MIR548E Gene

GeneLoc Exon Structure for
MIR548E

No data available for mRNA/cDNA for MIR548E Gene

Expression for MIR548E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548E Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR548E

genes like me logo Genes that share expression patterns with MIR548E: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548E Gene

Orthologs for MIR548E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-548e 31
  • 98 (a)
OneToOne
Species where no ortholog for MIR548E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR548E Gene

ENSEMBL:
Gene Tree for MIR548E (if available)
TreeFam:
Gene Tree for MIR548E (if available)

Paralogs for MIR548E Gene

No data available for Paralogs for MIR548E Gene

Variants for MIR548E Gene

Additional dbSNP identifiers (rs#s) for MIR548E Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR548E Gene

Variant ID Type Subtype PubMed ID
dgv974n100 CNV loss 25217958
dgv975n100 CNV loss 25217958
nsv1035422 CNV loss 25217958
nsv1035602 CNV loss 25217958
nsv1047412 CNV loss 25217958
nsv7211 OTHER inversion 18451855
nsv831985 CNV gain+loss 17160897

Additional Variant Information for MIR548E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR548E Gene

Disorders for MIR548E Gene

No disorders were found for MIR548E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548E Gene

Publications for MIR548E Gene

  1. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  2. Birth and expression evolution of mammalian microRNA genes. (PMID: 23034410) Meunier J … Kaessmann H (Genome research 2013) 3
  3. Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. (PMID: 18285502) Morin RD … Marra MA (Genome research 2008) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR548E Gene

Sources for MIR548E Gene