microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548D1 Gene

Data sources for MIR548D1 Gene:

RNA type for MIR548D1 Gene

miRNA

Aliases for MIR548D1 Gene

External Ids for MIR548D1 Gene

Previous HGNC Symbols for MIR548D1 Gene

  • MIRN548D1

Previous GeneCards Identifiers for MIR548D1 Gene

  • GC08M124430
  • GC08P124362
  • GC08M124364

Summaries for MIR548D1 Gene

Entrez Gene Summary for MIR548D1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548D1 Gene

MIR548D1 (MicroRNA 548d-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR548D1 include Autonomic Nervous System Disease and Alexithymia. Among its related pathways are miRNA targets in ECM and membrane receptors.

Additional gene information for MIR548D1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548D1 Gene

Genomics for MIR548D1 Gene

Genomic Locations for MIR548D1 Gene

Latest Assembly
chr8:123,348,034-123,348,130
(GRCh38/hg38)
Size:
97 bases
Orientation:
Minus strand

Previous Assembly
chr8:124,360,274-124,360,370
(GRCh37/hg19 by Entrez Gene)
Size:
97 bases
Orientation:
Minus strand

Genomic View for MIR548D1 Gene

Genes around MIR548D1 on UCSC Golden Path with GeneCards custom track
MIR548D1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR548D1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548D1 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR548D1 Gene

Proteins for MIR548D1 Gene

Post-translational modifications for MIR548D1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548D1 Gene

Domains & Families for MIR548D1 Gene

Gene Families for MIR548D1 Gene

genes like me logo Genes that share domains with MIR548D1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548D1 Gene

Function for MIR548D1 Gene

Gene Ontology (GO) - Molecular Function for MIR548D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 24929254
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24929254
genes like me logo Genes that share ontologies with MIR548D1: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548D1 Gene

Localization for MIR548D1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548D1 Gene

Pathways & Interactions for MIR548D1 Gene

PathCards logo

SuperPathways for MIR548D1 Gene

genes like me logo Genes that share pathways with MIR548D1: view

Pathways by source for MIR548D1 Gene

1 BioSystems pathway for MIR548D1 Gene

Gene Ontology (GO) - Biological Process for MIR548D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 24929254
GO:0045599 negative regulation of fat cell differentiation IDA 24929254
GO:0045669 positive regulation of osteoblast differentiation IDA 24929254
genes like me logo Genes that share ontologies with MIR548D1: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR548D1 Gene

Drugs & Compounds for MIR548D1 Gene

No Compound Related Data Available

Transcripts for MIR548D1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR548D1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000039FBF7_9606 miRNA 22 5

RefSeq: NR_030382, NR_030385,

LncBase: hsa-miR-548d-3p,

miRBase: MIMAT0003323,

TarBase: hsa-miR-548d-3p,

ENA: LM379887.1:1..22:ncRNA, LM609589.1:61..82:ncRNA, LM609590.1:61..82:ncRNA,

URS00005F2D64_9606 miRNA 22 5

RefSeq: NR_030382, NR_030385,

LncBase: hsa-miR-548d-5p,

miRBase: MIMAT0004812,

TarBase: hsa-miR-548d-5p,

ENA: LM380421.1:1..22:ncRNA, LM609589.1:25..46:ncRNA, LM609590.1:25..46:ncRNA,

URS000075B920_9606 pre_miRNA 97 4

RefSeq: NR_030382,

Ensembl: ENST00000636914 (view in UCSC) ,

miRBase: MI0003668,

ENA: LM609589.1:1..97:precursor_RNA,

MIR548D1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548D1 Gene

No ASD Table

Relevant External Links for MIR548D1 Gene

GeneLoc Exon Structure for
MIR548D1

No data available for mRNA/cDNA for MIR548D1 Gene

Expression for MIR548D1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR548D1

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548D1 Gene

Orthologs for MIR548D1 Gene

Evolution for MIR548D1 Gene

ENSEMBL:
Gene Tree for MIR548D1 (if available)
TreeFam:
Gene Tree for MIR548D1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR548D1

No data available for Orthologs for MIR548D1 Gene

Paralogs for MIR548D1 Gene

No data available for Paralogs for MIR548D1 Gene

Variants for MIR548D1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR548D1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR548D1 Gene

Variant ID Type Subtype PubMed ID
nsv831449 CNV loss 17160897

Additional Variant Information for MIR548D1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548D1
Leiden Open Variation Database (LOVD)
MIR548D1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR548D1 Gene

Disorders for MIR548D1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR548D1 Gene - From: COP

Disorder Aliases PubMed IDs
autonomic nervous system disease
  • autonomic nervous system disorder
alexithymia
paine syndrome
  • microcephaly with spastic diplegia
agoraphobia
  • fear of open spaces
disease of mental health
  • mental health
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR548D1

genes like me logo Genes that share disorders with MIR548D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR548D1 Gene

Publications for MIR548D1 Gene

  1. miR-548d-3p inhibits osteosarcoma by downregulating KRAS. (PMID: 31327761) Chen J … Yuan Q (Aging 2019) 3
  2. Downregulation of PPARγ by miR-548d-5p suppresses the adipogenic differentiation of human bone marrow mesenchymal stem cells and enhances their osteogenic potential. (PMID: 24929254) Sun J … Zhao G (Journal of translational medicine 2014) 3
  3. MicroRNA miR-548d is a superior regulator in pancreatic cancer. (PMID: 21946813) Heyn H … Beger C (Pancreas 2012) 3
  4. Preliminary validation of ERBB2 expression regulated by miR-548d-3p and miR-559. (PMID: 19486885) Chen H … Chen ZT (Biochemical and biophysical research communications 2009) 3
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3

Products for MIR548D1 Gene

Sources for MIR548D1 Gene