microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548C Gene

Subcategory (RNA class) for MIR548C Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR548C Gene

  • MicroRNA 548c 2 3 5
  • Hsa-MiR-548am-5p 166 177
  • Hsa-MiR-548c-5p 166 177
  • Hsa-MiR-548o-5p 166 177
  • Hsa-Mir-548c 3
  • MIMAT0022740 51
  • MIMAT0004806 51
  • MIMAT0003285 51
  • MIMAT0022738 51
  • MI0003630 51
  • MIRN548C 3
  • MIR548C 2

External Ids for MIR548C Gene

Previous HGNC Symbols for MIR548C Gene

  • MIRN548C

Previous GeneCards Identifiers for MIR548C Gene

  • GC12P063303
  • GC12P065016

Summaries for MIR548C Gene

Entrez Gene Summary for MIR548C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548C Gene

MIR548C (MicroRNA 548c) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR548C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548C Gene

Genomics for MIR548C Gene

GeneHancer (GH) Regulatory Elements for MIR548C Gene

Promoters and enhancers for MIR548C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR548C Gene

Genomic Locations for MIR548C Gene
chr12:64,622,509-64,622,605
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr12:65,016,289-65,016,385
(GRCh37/hg19)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR548C Gene

Genes around MIR548C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548C Gene

Proteins for MIR548C Gene

Post-translational modifications for MIR548C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548C Gene

Domains & Families for MIR548C Gene

Gene Families for MIR548C Gene

genes like me logo Genes that share domains with MIR548C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548C Gene

Function for MIR548C Gene

Phenotypes From GWAS Catalog for MIR548C Gene

Gene Ontology (GO) - Molecular Function for MIR548C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 28111633
genes like me logo Genes that share ontologies with MIR548C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548C Gene

Localization for MIR548C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548C Gene

Pathways & Interactions for MIR548C Gene

PathCards logo

SuperPathways for MIR548C Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR548C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IGI 28111633
GO:0010629 negative regulation of gene expression IDA 28111633
GO:0035195 gene silencing by miRNA IDA 28111633
GO:0060045 positive regulation of cardiac muscle cell proliferation IDA 28111633
genes like me logo Genes that share ontologies with MIR548C: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR548C Gene

Drugs & Compounds for MIR548C Gene

No Compound Related Data Available

Transcripts for MIR548C Gene

mRNA/cDNA for MIR548C Gene

3 RNACentral transcripts :
3 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
5 miRBase transcripts :
8 ENA transcripts :
3 LncBase transcripts :
3 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548C Gene

No ASD Table

Relevant External Links for MIR548C Gene

GeneLoc Exon Structure for
MIR548C

Expression for MIR548C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR548C

genes like me logo Genes that share expression patterns with MIR548C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548C Gene

Orthologs for MIR548C Gene

Evolution for MIR548C Gene

ENSEMBL:
Gene Tree for MIR548C (if available)
TreeFam:
Gene Tree for MIR548C (if available)

No data available for Orthologs for MIR548C Gene

Paralogs for MIR548C Gene

No data available for Paralogs for MIR548C Gene

Variants for MIR548C Gene

Additional dbSNP identifiers (rs#s) for MIR548C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR548C Gene

Variant ID Type Subtype PubMed ID
dgv2682n54 CNV gain 21841781
nsv832443 CNV loss 17160897
nsv832444 CNV loss 17160897

Additional Variant Information for MIR548C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR548C Gene

Disorders for MIR548C Gene

Additional Disease Information for MIR548C

No disorders were found for MIR548C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548C Gene

Publications for MIR548C Gene

  1. miR-548b-3p Regulates Proliferation, Apoptosis, and Mitochondrial Function by Targeting CIP2A in Hepatocellular Carcinoma. (PMID: 30671469) Lin L … Wang Y (BioMed research international 2018) 3 54
  2. Plasma microRNA expression signature involving miR-548q, miR-630 and miR-940 as biomarkers for nasopharyngeal carcinoma detection. (PMID: 30475754) Zhuo X … Zhou Q (Cancer biomarkers : section A of Disease markers 2018) 3 54
  3. Up-regulated miR-548k promotes esophageal squamous cell carcinoma progression via targeting long noncoding RNA-LET. (PMID: 29126868) Chen Z … Huang Z (Experimental cell research 2018) 3 54
  4. Altered Expression of miRNAs Is Related to Larynx Cancer TNM Stage and Patients' Smoking Status. (PMID: 28430523) Bruzgielewicz A … Majsterek I (DNA and cell biology 2017) 3 54
  5. Identification of novel microRNAs regulating HLA-G expression and investigating their clinical relevance in renal cell carcinoma. (PMID: 27057628) Jasinski-Bergner S … Seliger B (Oncotarget 2016) 3 54

Products for MIR548C Gene

Sources for MIR548C Gene