Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR548AC (MicroRNA 548ac) is an RNA Gene, and is affiliated with the miRNA class.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH01J116555 | Enhancer | 1.4 | FANTOM5 ENCODE dbSUPER | 250.7 | +1.9 | 1925 | 6.2 | SP1 BCL11A NR2C1 MNT IKZF1 POLR2A BRCA1 CEBPB ZNF395 ZNF639 | MIR548AC CD58 ATP1A1 CD2 ATP1A1-AS1 CD101 ENSG00000230381 RF00994-049 lnc-ATP1A1-1 | |
GH01J116562 | Enhancer | 0.7 | ENCODE dbSUPER | 0.7 | -2.4 | -2395 | 0.3 | BHLHE40 XRCC3 EHMT2 ZBTB33 NBN CHAMP1 RELB MLLT1 | ENSG00000230381 IGSF3 MIR320B1 MIR548AC CD58 lnc-ATP1A1-1 ATP1A1 | |
GH01J116553 | Enhancer | 0.8 | ENCODE dbSUPER | 0.4 | +6.3 | 6257 | 1.2 | IKZF1 EBF1 BATF PKNOX1 NFATC1 BMI1 HDGF IKZF2 MTA2 EED | ATP1A1 IGSF3 MIR320B1 RF00994-049 ENSG00000230381 MIR548AC CD58 lnc-ATP1A1-1 | |
GH01J116551 | Promoter/Enhancer | 0.7 | Ensembl dbSUPER | 0.4 | +8.4 | 8410 | 0.2 | HDGF PRDM1 | RF00994-049 ATP1A1 MIR548AC ENSG00000230381 CD58 lnc-ATP1A1-1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075BB42_9606 | precursor_RNA | 88 | 4 |
RefSeq: NR_039621, Ensembl: ENST00000585049 (view in UCSC) , miRBase: MI0016762, |
URS00002CE0C6_9606 | miRNA | 22 | 3 |
RefSeq: NR_039621, miRBase: MIMAT0018938, |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToOne |
No disorders were found for MIR548AC Gene.