microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548AC Gene

Data sources for MIR548AC Gene:

Subcategory (RNA class) for MIR548AC Gene


Aliases for MIR548AC Gene

External Ids for MIR548AC Gene

Previous GeneCards Identifiers for MIR548AC Gene

  • GC01U903272
  • GC01M117104

Summaries for MIR548AC Gene

Entrez Gene Summary for MIR548AC Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548AC Gene

MIR548AC (MicroRNA 548ac) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR548AC Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548AC Gene

Genomics for MIR548AC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR548AC Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J116555 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 250.7 +1.9 1925 6.2 SP1 BCL11A NR2C1 MNT IKZF1 POLR2A BRCA1 CEBPB ZNF395 ZNF639 MIR548AC CD58 ATP1A1 CD2 ATP1A1-AS1 CD101 ENSG00000230381 RF00994-049 lnc-ATP1A1-1
GH01J116562 Enhancer 0.7 ENCODE dbSUPER 0.7 -2.4 -2395 0.3 BHLHE40 XRCC3 EHMT2 ZBTB33 NBN CHAMP1 RELB MLLT1 ENSG00000230381 IGSF3 MIR320B1 MIR548AC CD58 lnc-ATP1A1-1 ATP1A1
GH01J116553 Enhancer 0.8 ENCODE dbSUPER 0.4 +6.3 6257 1.2 IKZF1 EBF1 BATF PKNOX1 NFATC1 BMI1 HDGF IKZF2 MTA2 EED ATP1A1 IGSF3 MIR320B1 RF00994-049 ENSG00000230381 MIR548AC CD58 lnc-ATP1A1-1
GH01J116551 Promoter/Enhancer 0.7 Ensembl dbSUPER 0.4 +8.4 8410 0.2 HDGF PRDM1 RF00994-049 ATP1A1 MIR548AC ENSG00000230381 CD58 lnc-ATP1A1-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548AC on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR548AC Gene

Latest Assembly
88 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
88 bases
Minus strand

(GRCh37/hg19 by Ensembl)
88 bases
Minus strand

Genomic View for MIR548AC Gene

Genes around MIR548AC on UCSC Golden Path with GeneCards custom track
MIR548AC in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR548AC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548AC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548AC Gene

Proteins for MIR548AC Gene

Post-translational modifications for MIR548AC Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548AC Gene

Domains & Families for MIR548AC Gene

Gene Families for MIR548AC Gene

genes like me logo Genes that share domains with MIR548AC: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548AC Gene

Function for MIR548AC Gene

Phenotypes From GWAS Catalog for MIR548AC Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548AC Gene

Localization for MIR548AC Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548AC Gene

Pathways & Interactions for MIR548AC Gene

PathCards logo

SuperPathways for MIR548AC Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR548AC Gene


No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR548AC Gene

Drugs & Compounds for MIR548AC Gene

No Compound Related Data Available

Transcripts for MIR548AC Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR548AC Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075BB42_9606 precursor_RNA 88 4

RefSeq: NR_039621,

Ensembl: ENST00000585049 (view in UCSC) ,

miRBase: MI0016762,

ENA: LM611286.1:1..88:precursor_RNA,

URS00002CE0C6_9606 miRNA 22 3

RefSeq: NR_039621,

miRBase: MIMAT0018938,

ENA: LM382382.1:1..22:ncRNA, LM611286.1:53..74:ncRNA,

MIR548AC in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548AC Gene

No ASD Table

Relevant External Links for MIR548AC Gene

GeneLoc Exon Structure for

No data available for mRNA/cDNA for MIR548AC Gene

Expression for MIR548AC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548AC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR548AC

genes like me logo Genes that share expression patterns with MIR548AC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548AC Gene

Orthologs for MIR548AC Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548AC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
Species where no ortholog for MIR548AC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR548AC Gene

Gene Tree for MIR548AC (if available)
Gene Tree for MIR548AC (if available)

Paralogs for MIR548AC Gene

No data available for Paralogs for MIR548AC Gene

Variants for MIR548AC Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR548AC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR548AC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR548AC Gene

Disorders for MIR548AC Gene

Additional Disease Information for MIR548AC

No disorders were found for MIR548AC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548AC Gene

Publications for MIR548AC Gene

  1. A genetic variant associated with multiple sclerosis inversely affects the expression of CD58 and microRNA-548ac from the same gene. (PMID: 30730892) Hecker M … Zettl UK (PLoS genetics 2019) 3
  2. Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis. (PMID: 25795118) Hecker M … Zettl UK (Mutation research. Reviews in mutation research 2015) 3
  3. Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. (PMID: 22190364) Patsopoulos NA … de Bakker PI (Annals of neurology 2011) 3
  4. Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs. (PMID: 20733160) Jima DD … Hematologic Malignancies Research Consortium (Blood 2010) 3
  5. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. (PMID: 19525953) De Jager PL … Oksenberg JR (Nature genetics 2009) 3

Products for MIR548AC Gene

Sources for MIR548AC Gene