microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548AA1 Gene

Data sources for MIR548AA1 Gene:

RNA type for MIR548AA1 Gene

miRNA

Aliases for MIR548AA1 Gene

External Ids for MIR548AA1 Gene

Previous GeneCards Identifiers for MIR548AA1 Gene

  • GC08U901479
  • GC08P124361

Summaries for MIR548AA1 Gene

Entrez Gene Summary for MIR548AA1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548AA1 Gene

MIR548AA1 (MicroRNA 548aa-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR548AA1 include Microcephalic Osteodysplastic Primordial Dwarfism, Type I and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome. Among its related pathways are miRNA targets in ECM and membrane receptors.

Additional gene information for MIR548AA1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548AA1 Gene

Genomics for MIR548AA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR548AA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548AA1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR548AA1 Gene

Latest Assembly
chr8:123,348,034-123,348,130
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand

Previous Assembly
chr8:124,360,274-124,360,370
(GRCh37/hg19 by Entrez Gene)
Size:
97 bases
Orientation:
Plus strand

chr8:124,360,274-124,360,370
(GRCh37/hg19 by Ensembl)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR548AA1 Gene

Genes around MIR548AA1 on UCSC Golden Path with GeneCards custom track
MIR548AA1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR548AA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548AA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548AA1 Gene

Proteins for MIR548AA1 Gene

Post-translational modifications for MIR548AA1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548AA1 Gene

Domains & Families for MIR548AA1 Gene

Gene Families for MIR548AA1 Gene

genes like me logo Genes that share domains with MIR548AA1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548AA1 Gene

Function for MIR548AA1 Gene

Phenotypes From GWAS Catalog for MIR548AA1 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548AA1 Gene

Localization for MIR548AA1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548AA1 Gene

Pathways & Interactions for MIR548AA1 Gene

PathCards logo

SuperPathways for MIR548AA1 Gene

genes like me logo Genes that share pathways with MIR548AA1: view

Pathways by source for MIR548AA1 Gene

1 BioSystems pathway for MIR548AA1 Gene

Gene Ontology (GO) - Biological Process for MIR548AA1 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR548AA1 Gene

Drugs & Compounds for MIR548AA1 Gene

No Compound Related Data Available

Transcripts for MIR548AA1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR548AA1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000012930C_9606 miRNA 25 5

RefSeq: NR_036093, NR_037516, NR_037517,

LncBase: hsa-miR-548aa, hsa-miR-548t-3p,

miRBase: MIMAT0018447,

TarBase: hsa-miR-548aa, hsa-miR-548t-3p,

ENA: LM382187.1:1..25:ncRNA, LM383031.1:1..25:ncRNA, LM610991.1:46..70:ncRNA, LM611270.1:55..79:ncRNA, LM611271.1:55..79:ncRNA,

URS000075DA4B_9606 precursor_RNA 97 4

RefSeq: NR_037516,

Ensembl: ENST00000384971 (view in UCSC) ,

miRBase: MI0016689,

ENA: LM611270.1:1..97:precursor_RNA,

MIR548AA1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548AA1 Gene

No ASD Table

Relevant External Links for MIR548AA1 Gene

GeneLoc Exon Structure for
MIR548AA1

No data available for mRNA/cDNA for MIR548AA1 Gene

Expression for MIR548AA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548AA1 Gene

genes like me logo Genes that share expression patterns with MIR548AA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548AA1 Gene

Orthologs for MIR548AA1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548AA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 85 (a)
ManyToMany
Species where no ortholog for MIR548AA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR548AA1 Gene

ENSEMBL:
Gene Tree for MIR548AA1 (if available)
TreeFam:
Gene Tree for MIR548AA1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR548AA1

Paralogs for MIR548AA1 Gene

No data available for Paralogs for MIR548AA1 Gene

Variants for MIR548AA1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR548AA1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR548AA1 Gene

Variant ID Type Subtype PubMed ID
nsv831449 CNV loss 17160897

Additional Variant Information for MIR548AA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548AA1
Leiden Open Variation Database (LOVD)
MIR548AA1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR548AA1 Gene

Disorders for MIR548AA1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MIR548AA1 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR548AA1

genes like me logo Genes that share disorders with MIR548AA1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR548AA1 Gene

Publications for MIR548AA1 Gene

  1. Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls. (PMID: 20459774) Witten D … Lui WO (BMC biology 2010) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR548AA1 Gene

Sources for MIR548AA1 Gene