microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR548A1 Gene

Subcategory (RNA class) for MIR548A1 Gene

miRNA

Number of RNA Genes sources:

4 / 14

Aliases for MIR548A1 Gene

  • MicroRNA 548a-1 2 3 5
  • Hsa-MiR-548a-3p 166 177
  • Hsa-Mir-548a-1 3
  • MIMAT0003251 51
  • MIRN548A1 3
  • MI0003593 51
  • MIR548A1 2

External Ids for MIR548A1 Gene

Previous HGNC Symbols for MIR548A1 Gene

  • MIRN548A1

Previous GeneCards Identifiers for MIR548A1 Gene

  • GC06P018680

Summaries for MIR548A1 Gene

Entrez Gene Summary for MIR548A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR548A1 Gene

MIR548A1 (MicroRNA 548a-1) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR548A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR548A1 Gene

Genomics for MIR548A1 Gene

GeneHancer (GH) Regulatory Elements for MIR548A1 Gene

Promoters and enhancers for MIR548A1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J018595 Enhancer 0.6 Ensembl 11 +24.6 24573 1.1 CTCF REST RAD21 TRIM22 SMC3 FOXA2 NR2F2 ZNF189 ZNF654 EGR1 MIR548A1 piR-57133-509 MIR548A1HG
GH06J018545 Enhancer 0.4 Ensembl 11.3 -25.9 -25883 1 FOS TBX21 JUN MTA2 MIR548A1 DEK MIR548A1HG piR-32214-573 RF00100-125
GH06J018584 Enhancer 1.1 Ensembl ENCODE 0.4 +13.7 13716 1.8 ZBTB40 RBAK JUND FOS ZNF639 ZIC2 REST ZBTB10 ZBTB11 ZNF623 NUP153 DEK MIR548A1 piR-57133-509 MIR548A1HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR548A1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR548A1 Gene

Genomic Locations for MIR548A1 Gene
chr6:18,571,784-18,571,880
(GRCh38/hg38)
Size:
97 bases
Orientation:
Plus strand
chr6:18,572,015-18,572,111
(GRCh37/hg19)
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR548A1 Gene

Genes around MIR548A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR548A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR548A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR548A1 Gene

Proteins for MIR548A1 Gene

Post-translational modifications for MIR548A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR548A1 Gene

Domains & Families for MIR548A1 Gene

Gene Families for MIR548A1 Gene

genes like me logo Genes that share domains with MIR548A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR548A1 Gene

Function for MIR548A1 Gene

Phenotypes From GWAS Catalog for MIR548A1 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR548A1 Gene

Localization for MIR548A1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR548A1 Gene

Pathways & Interactions for MIR548A1 Gene

PathCards logo

SuperPathways for MIR548A1 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR548A1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR548A1 Gene

Drugs & Compounds for MIR548A1 Gene

No Compound Related Data Available

Transcripts for MIR548A1 Gene

mRNA/cDNA for MIR548A1 Gene

2 RNACentral transcripts :
3 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :
5 ENA transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR548A1 Gene

No ASD Table

Relevant External Links for MIR548A1 Gene

GeneLoc Exon Structure for
MIR548A1

Expression for MIR548A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR548A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR548A1

genes like me logo Genes that share expression patterns with MIR548A1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR548A1 Gene

Orthologs for MIR548A1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR548A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-548a-1 31
  • 98 (a)
OneToOne
Species where no ortholog for MIR548A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR548A1 Gene

ENSEMBL:
Gene Tree for MIR548A1 (if available)
TreeFam:
Gene Tree for MIR548A1 (if available)

Paralogs for MIR548A1 Gene

No data available for Paralogs for MIR548A1 Gene

Variants for MIR548A1 Gene

Additional dbSNP identifiers (rs#s) for MIR548A1 Gene

Additional Variant Information for MIR548A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR548A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR548A1 Gene

Disorders for MIR548A1 Gene

Additional Disease Information for MIR548A1

No disorders were found for MIR548A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR548A1 Gene

Publications for MIR548A1 Gene

  1. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54
  3. The colorectal microRNAome. (PMID: 16505370) Cummins JM … Velculescu VE (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 54

Products for MIR548A1 Gene

Sources for MIR548A1 Gene