microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR541 Gene

Subcategory (RNA class) for MIR541 Gene


Number of RNA Genes sources:

6 / 17

Aliases for MIR541 Gene

  • MIMAT0004919 50
  • MIMAT0004920 50
  • MI0005539 50
  • MIRN541 3
  • Mir-541 3
  • RF00777 168

External Ids for MIR541 Gene

Previous HGNC Symbols for MIR541 Gene

  • MIRN541

Previous GeneCards Identifiers for MIR541 Gene

  • GC14P100839
  • GC14P100929
  • GC14P101530
  • GC14P101272
  • GC14P101888
  • GC14P103639
  • GC14P103857
  • GC14P104134
  • GC14P104475
  • GC14P102204
  • GC14P102372
  • GC14P102550
  • GC14P102724
  • GC14P102894
  • GC14P103070
  • GC14P103266
  • GC14P103456

Summaries for MIR541 Gene

Entrez Gene Summary for MIR541 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR541 Gene

MIR541 (MicroRNA 541) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR541 include Bile Duct Adenocarcinoma and Renal Artery Disease.

Rfam classification for MIR541 Gene

Additional gene information for MIR541 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR541 Gene

Genomics for MIR541 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR541 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J101062 Enhancer 0.8 Ensembl ENCODE CraniofacialAtlas 600.7 -1.8 -1793 2.9 NR2F2 CTCF JUN RAD21 MIR377 MEG9 MIR541 RTL1 DIO3
GH14J101096 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.4 +33.8 33776 3.3 ATF7 KDM1A SPI1 ATF4 MAFK JUN POLR2A RTL1 ENSG00000230805 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14J101095 Enhancer 0.2 Ensembl 11.4 +31.2 31210 0.2 MIR410 MIR656 MEG9 MIR369 MIR409 MIR412 MIR541 MIR377 MIR154 MIR323B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR541 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR541 Gene

Genomic Locations for MIR541 Gene
90 bases
Plus strand
84 bases
Plus strand

Genomic View for MIR541 Gene

Genes around MIR541 on UCSC Golden Path with GeneCards custom track
MIR541 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR541 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR541 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR541 Gene

Proteins for MIR541 Gene

Post-translational modifications for MIR541 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR541 Gene

Domains & Families for MIR541 Gene

Gene Families for MIR541 Gene

genes like me logo Genes that share domains with MIR541: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR541 Gene

Function for MIR541 Gene

Phenotypes From GWAS Catalog for MIR541 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR541 Gene

Localization for MIR541 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR541 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR541 Gene

Pathways & Interactions for MIR541 Gene

PathCards logo

SuperPathways for MIR541 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR541 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR541: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR541 Gene

Drugs & Compounds for MIR541 Gene

No Compound Related Data Available

Transcripts for MIR541 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR541 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000076E54_9606 miRNA 25 6

RefSeq: NR_030594,

LncBase: hsa-miR-541-5p,

miRBase: MIMAT0004919,

MirGeneDB: Hsa-Mir-541_5p,

TarBase: hsa-miR-541-5p,

ENA: LM380485.1:1..25:ncRNA, LM609947.1:10..34:ncRNA,

URS000075A3AC_9606 miRNA 22 6

RefSeq: NR_030594,

LncBase: hsa-miR-541-3p,

miRBase: MIMAT0004920,

MirGeneDB: Hsa-Mir-541_3p,

TarBase: hsa-miR-541-3p,

ENA: LM609947.1:54..75:ncRNA,

URS000075BC5F_9606 precursor_RNA 84 5

HGNC: 33650,

RefSeq: NR_030594,

Ensembl: ENST00000401360 (view in UCSC) ,

miRBase: MI0005539,

ENA: LM609947.1:1..84:precursor_RNA,

URS00006B8421_9606 precursor_RNA 90 1

Rfam: RF00777,

URS0000EFBE97_9606 precursor_RNA 67 1

MirGeneDB: Hsa-Mir-541,

MIR541 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR541 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR541 Gene

No ASD Table

Relevant External Links for MIR541 Gene

GeneLoc Exon Structure for

Expression for MIR541 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR541 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR541

genes like me logo Genes that share expression patterns with MIR541: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR541 Gene

Orthologs for MIR541 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR541 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-541 31
  • 95 (a)
(Canis familiaris)
Mammalia -- 31
  • 88 (a)
(Pan troglodytes)
Mammalia -- 31
  • 70 (a)
(Mus musculus)
Mammalia Mir541 31
  • 69 (a)
Species where no ortholog for MIR541 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR541 Gene

Gene Tree for MIR541 (if available)
Gene Tree for MIR541 (if available)

Paralogs for MIR541 Gene

No data available for Paralogs for MIR541 Gene

Variants for MIR541 Gene

Additional dbSNP identifiers (rs#s) for MIR541 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR541 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv509551 CNV insertion 20534489
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Additional Variant Information for MIR541 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR541 Gene

Disorders for MIR541 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR541 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bile duct adenocarcinoma
renal artery disease
  • renal vascular disease
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR541: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR541 Gene

Publications for MIR541 Gene

  1. CyclinD1 inhibits dicer and crucial miRNA expression by chromatin modification to promote the progression of intrahepatic cholangiocarcinoma. (PMID: 31590696) Qi Y … Chen Y (Journal of experimental & clinical cancer research : CR 2019) 3
  2. Long noncoding RNA LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1. (PMID: 30278884) Long B … Wu ZH (Biochemical and biophysical research communications 2018) 3
  3. miR-541 suppresses proliferation and invasion of squamous cell lung carcinoma cell lines via directly targeting high-mobility group AT-hook 2. (PMID: 29659195) Xu L … Liao WL (Cancer medicine 2018) 3
  4. MiR-541-3p reverses cancer progression by directly targeting TGIF2 in non-small cell lung cancer. (PMID: 27448300) Lu YJ … Wang Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3
  5. Infiltrating T cells promote prostate cancer metastasis via modulation of FGF11→miRNA-541→androgen receptor (AR)→MMP9 signaling. (PMID: 25135278) Hu S … Chang C (Molecular oncology 2015) 3

Products for MIR541 Gene

Sources for MIR541 Gene