microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR532 Gene

RNA type for MIR532 Gene

miRNA

Aliases for MIR532 Gene

External Ids for MIR532 Gene

Previous HGNC Symbols for MIR532 Gene

  • MIRN532

Previous GeneCards Identifiers for MIR532 Gene

  • GC0XP049656
  • GC0XP049767

Summaries for MIR532 Gene

Entrez Gene Summary for MIR532 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR532 Gene

MIR532 (MicroRNA 532) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR532 include Melanoma and Kidney Cancer. Among its related pathways are miRNA targets in ECM and membrane receptors.

Rfam classification for MIR532 Gene

Additional gene information for MIR532 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR532 Gene

Genomics for MIR532 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR532 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ050002 Enhancer 0.6 Ensembl 250.7 -1.5 -1541 2.8 IRF4 NFE2 SPI1 MAFG IKZF1 TARDBP IKZF2 MTA2 EED NBN MIR188 MIR532 CLCN5 piR-37026-645 NONHSAG054474.2 AKAP4
GH0XJ049976 Enhancer 0.7 Ensembl ENCODE 11.9 -24.8 -24785 3 FEZF1 PRDM6 PRDM4 GATA2 TRIM28 BCL6B IKZF1 PRDM10 MIR532 MIR188 MIR362 MIR500A MIR500B MIR501 CLCN5 piR-37026-645 NONHSAG054474.2 AKAP4
GH0XJ049957 Enhancer 0.4 Ensembl ENCODE 12.5 -43.9 -43867 4.5 SPI1 MIR188 MIR532 MIR362 MIR500A MIR500B MIR501 CLCN5 piR-37026-645 RF00026-1124 RNU6-421P
GH0XJ049981 Enhancer 0.3 Ensembl 12.7 -21.1 -21141 1.6 MAFK MIR188 MIR532 MIR362 MIR500A MIR500B MIR501 piR-37026-645 NONHSAG054474.2 CLCN5 AKAP4
GH0XJ049956 Enhancer 0.3 Ensembl 12.5 -46.8 -46841 0.2 RFX1 MIR188 MIR532 MIR362 MIR500A MIR500B MIR501 RF00026-1124 RNU6-421P piR-37026-645 CLCN5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR532 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR532 Gene

Latest Assembly
chrX:50,003,142-50,003,247
(GRCh38/hg38)
Size:
106 bases
Orientation:
Plus strand

Previous Assembly
chrX:49,767,754-49,767,844
(GRCh37/hg19 by Ensembl)
Size:
91 bases
Orientation:
Plus strand

Genomic View for MIR532 Gene

Genes around MIR532 on UCSC Golden Path with GeneCards custom track
MIR532 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR532 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR532 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR532 Gene

Proteins for MIR532 Gene

Post-translational modifications for MIR532 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR532 Gene

Domains & Families for MIR532 Gene

Gene Families for MIR532 Gene

genes like me logo Genes that share domains with MIR532: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR532 Gene

Function for MIR532 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR532 Gene

Localization for MIR532 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR532 gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MIR532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR532: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR532 Gene

Pathways & Interactions for MIR532 Gene

PathCards logo

SuperPathways for MIR532 Gene

genes like me logo Genes that share pathways with MIR532: view

Pathways by source for MIR532 Gene

1 BioSystems pathway for MIR532 Gene

Gene Ontology (GO) - Biological Process for MIR532 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR532: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR532 Gene

Drugs & Compounds for MIR532 Gene

No Compound Related Data Available

Transcripts for MIR532 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR532 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004B4B85_9606 miRNA 22 6

RefSeq: NR_030241,

LncBase: hsa-miR-532-3p,

miRBase: MIMAT0004780,

MirGeneDB: Hsa-Mir-188-P2_3p,

TarBase: hsa-miR-532-3p,

ENA: LM380394.1:1..22:ncRNA, LM609515.1:57..78:ncRNA,

URS00004E8341_9606 miRNA 22 6

RefSeq: NR_030241,

LncBase: hsa-miR-532-5p,

miRBase: MIMAT0002888,

MirGeneDB: Hsa-Mir-188-P2_5p,

TarBase: hsa-miR-532-5p,

ENA: LM379811.1:1..22:ncRNA, LM609515.1:20..41:ncRNA,

URS00007B250F_9606 pre_miRNA 91 4

RefSeq: NR_030241,

Ensembl: ENST00000385025 (view in UCSC) ,

miRBase: MI0003205,

ENA: LM609515.1:1..91:precursor_RNA,

URS0000686139_9606 pre_miRNA 106 1

Rfam: RF01897,

URS0000EFD6AE_9606 pre_miRNA 60 1

MirGeneDB: Hsa-Mir-188-P2,

MIR532 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR532 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR532 Gene

No ASD Table

Relevant External Links for MIR532 Gene

GeneLoc Exon Structure for
MIR532

Expression for MIR532 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR532

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR532 Gene

Orthologs for MIR532 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR532 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-532 30
  • 98 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia cfa-mir-532 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia bta-mir-532 30
  • 91 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mir532 30
  • 84 (a)
OneToOne
Species where no ortholog for MIR532 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR532 Gene

ENSEMBL:
Gene Tree for MIR532 (if available)
TreeFam:
Gene Tree for MIR532 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR532

Paralogs for MIR532 Gene

No data available for Paralogs for MIR532 Gene

Variants for MIR532 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR532 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
804001 Benign: Dent disease type 1 50,003,229(+) G/.
NM_001127898.4(CLCN5):c.17-39087=
NON_CODING_TRANSCRIPT_VARIANT,NO_SEQUENCE_ALTERATION,INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR532 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Additional Variant Information for MIR532 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR532
Leiden Open Variation Database (LOVD)
MIR532

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR532 Gene

Disorders for MIR532 Gene

MalaCards: The human disease database

(33) MalaCards diseases for MIR532 Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
kidney cancer
  • malignant neoplasm of kidney except pelvis
causalgia
  • complex regional pain syndrome, type ii
invasive bladder transitional cell carcinoma
  • invasive bladder urothelial carcinoma
ileum cancer
  • ileal neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR532

genes like me logo Genes that share disorders with MIR532: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR532 Gene

Publications for MIR532 Gene

  1. Regulation of RUNX3 tumor suppressor gene expression in cutaneous melanoma. (PMID: 19336521) Kitago M … Hoon DS (Clinical cancer research : an official journal of the American Association for Cancer Research 2009) 3 72
  2. Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/β-catenin signalling pathway. (PMID: 32633323) Dai X … Wang Z (Clinical science (London, England : 1979) 2020) 3
  3. Serum Exosomal miRNAs for Grading Hepatic Fibrosis Due to Schistosomiasis. (PMID: 32443549) Cai P … McManus DP (International journal of molecular sciences 2020) 3
  4. Circulating miR-532-502 cluster derived from chromosome X as biomarkers for diagnosis of breast cancer. (PMID: 31493506) Zou X … Zhu W (Gene 2020) 3
  5. Plasma exosome-derived microRNA-532 as a novel predictor for acute myeloid leukemia. (PMID: 32176633) Lin X … Jin J (Cancer biomarkers : section A of Disease markers 2020) 3

Products for MIR532 Gene

Sources for MIR532 Gene