microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR526B Gene

RNA type for MIR526B Gene

miRNA

Aliases for MIR526B Gene

External Ids for MIR526B Gene

Previous HGNC Symbols for MIR526B Gene

  • MIRN526B

Previous GeneCards Identifiers for MIR526B Gene

  • GC19P058891
  • GC19P054197

Summaries for MIR526B Gene

Entrez Gene Summary for MIR526B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR526B Gene

MIR526B (MicroRNA 526b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR526B include Placenta Disease.

Rfam classification for MIR526B Gene

Additional gene information for MIR526B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR526B Gene

Genomics for MIR526B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR526B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR526B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR526B Gene

Latest Assembly
chr19:53,694,391-53,694,477
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,197,647-54,197,729
(GRCh37/hg19 by Entrez Gene)
Size:
83 bases
Orientation:
Plus strand

chr19:54,197,647-54,197,729
(GRCh37/hg19 by Ensembl)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR526B Gene

Genes around MIR526B on UCSC Golden Path with GeneCards custom track
MIR526B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR526B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR526B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR526B Gene

Proteins for MIR526B Gene

Post-translational modifications for MIR526B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR526B Gene

Domains & Families for MIR526B Gene

Gene Families for MIR526B Gene

genes like me logo Genes that share domains with MIR526B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR526B Gene

Function for MIR526B Gene

Phenotypes From GWAS Catalog for MIR526B Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR526B Gene

Localization for MIR526B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR526B gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR526B Gene

Pathways & Interactions for MIR526B Gene

PathCards logo

SuperPathways for MIR526B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR526B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR526B: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR526B Gene

Drugs & Compounds for MIR526B Gene

No Compound Related Data Available

Transcripts for MIR526B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR526B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00004C21E4_9606 miRNA 23 5

RefSeq: NR_030190,

LncBase: hsa-miR-526b-5p,

miRBase: MIMAT0002835,

TarBase: hsa-miR-526b-5p,

ENA: AY882295.1:1..23:ncRNA,

URS000038B25B_9606 miRNA 22 5

RefSeq: NR_030190,

LncBase: hsa-miR-526b-3p,

miRBase: MIMAT0002836,

MirGeneDB: Hsa-Mir-430-P47_3p,

TarBase: hsa-miR-526b-3p,

URS000075D282_9606 pre_miRNA 83 3

RefSeq: NR_030190,

Ensembl: ENST00000384848 (view in UCSC) ,

miRBase: MI0003150,

URS000072140D_9606 pre_miRNA 87 1

Rfam: RF00639,

URS0000EFDD23_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-430-P47,

MIR526B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR526B Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR526B Gene

No ASD Table

Relevant External Links for MIR526B Gene

GeneLoc Exon Structure for
MIR526B

Expression for MIR526B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR526B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR526B

genes like me logo Genes that share expression patterns with MIR526B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR526B Gene

Orthologs for MIR526B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR526B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-526b 30
  • 98 (a)
OneToOne
Species where no ortholog for MIR526B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR526B Gene

ENSEMBL:
Gene Tree for MIR526B (if available)
TreeFam:
Gene Tree for MIR526B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR526B

Paralogs for MIR526B Gene

No data available for Paralogs for MIR526B Gene

Variants for MIR526B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR526B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR526B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718834 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR526B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR526B
Leiden Open Variation Database (LOVD)
MIR526B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR526B Gene

Disorders for MIR526B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR526B Gene - From: COP

Disorder Aliases PubMed IDs
placenta disease
  • placenta disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR526B

genes like me logo Genes that share disorders with MIR526B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR526B Gene

Publications for MIR526B Gene

  1. ATG7 promotes autophagy in sepsis‑induced acute kidney injury and is inhibited by miR‑526b. (PMID: 32323768) Liu Y … Bao H (Molecular medicine reports 2020) 3
  2. Long Noncoding RNA HOXD-AS1 Promotes the Proliferation, Migration, and Invasion of Colorectal Cancer via the miR-526b-3p/CCND1 Axis. (PMID: 32640404) Yan F … Sun J (The Journal of surgical research 2020) 3
  3. MiR-526b suppresses cell proliferation, cell invasion and epithelial-mesenchymal transition in breast cancer by targeting Twist1. (PMID: 32271429) Liu YQ … Peng MY (European review for medical and pharmacological sciences 2020) 3
  4. MiR-526b-3p mediates doxorubicin-induced cardiotoxicity by targeting STAT3 to inactivate VEGFA. (PMID: 31958751) Zhang L … Li X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020) 3
  5. By downregulating PBX3, miR-526b suppresses the epithelial-mesenchymal transition process in cervical cancer cells. (PMID: 30859853) Li H … Yang Y (Future oncology (London, England) 2019) 3

Products for MIR526B Gene

Sources for MIR526B Gene