microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR526B Gene

Subcategory (RNA class) for MIR526B Gene

miRNA

Number of RNA Genes sources:

5 / 14

Aliases for MIR526B Gene

  • MicroRNA 526b 2 3 5
  • Hsa-MiR-526b-5p 166 177
  • Hsa-MiR-526b-3p 166 177
  • Hsa-Mir-526b 3
  • MIMAT0002836 51
  • MIMAT0002835 51
  • MI0003150 51
  • MIRN526B 3
  • RF00639 172
  • MIR526B 2

External Ids for MIR526B Gene

Previous HGNC Symbols for MIR526B Gene

  • MIRN526B

Previous GeneCards Identifiers for MIR526B Gene

  • GC19P058891
  • GC19P054197

Summaries for MIR526B Gene

Entrez Gene Summary for MIR526B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR526B Gene

MIR526B (MicroRNA 526b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR526B include Placenta Disease and Uterine Anomalies.

Rfam classification for MIR526B Gene

Additional gene information for MIR526B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR526B Gene

Genomics for MIR526B Gene

GeneHancer (GH) Regulatory Elements for MIR526B Gene

Promoters and enhancers for MIR526B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR526B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR526B Gene

Genomic Locations for MIR526B Gene
chr19:53,694,391-53,694,477
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr19:54,197,647-54,197,729
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR526B Gene

Genes around MIR526B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR526B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR526B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR526B Gene

Proteins for MIR526B Gene

Post-translational modifications for MIR526B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR526B Gene

Domains & Families for MIR526B Gene

Gene Families for MIR526B Gene

genes like me logo Genes that share domains with MIR526B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR526B Gene

Function for MIR526B Gene

Phenotypes From GWAS Catalog for MIR526B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR526B Gene

Localization for MIR526B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR526B Gene

Pathways & Interactions for MIR526B Gene

PathCards logo

SuperPathways for MIR526B Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR526B Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR526B Gene

Drugs & Compounds for MIR526B Gene

No Compound Related Data Available

Transcripts for MIR526B Gene

mRNA/cDNA for MIR526B Gene

5 RNACentral transcripts :
1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
2 ENA transcripts :
2 LncBase transcripts :
1 Rfam transcripts :
2 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR526B Gene

No ASD Table

Relevant External Links for MIR526B Gene

GeneLoc Exon Structure for
MIR526B

Expression for MIR526B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR526B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR526B

genes like me logo Genes that share expression patterns with MIR526B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR526B Gene

Orthologs for MIR526B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR526B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-526b 31
  • 98 (a)
OneToOne
Species where no ortholog for MIR526B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR526B Gene

ENSEMBL:
Gene Tree for MIR526B (if available)
TreeFam:
Gene Tree for MIR526B (if available)

Paralogs for MIR526B Gene

No data available for Paralogs for MIR526B Gene

Variants for MIR526B Gene

Additional dbSNP identifiers (rs#s) for MIR526B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR526B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718834 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR526B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR526B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR526B Gene

Disorders for MIR526B Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR526B Gene - From: DISEASES

Disorder Aliases PubMed IDs
placenta disease
  • placenta disorder
uterine anomalies
  • uterine disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR526B

genes like me logo Genes that share disorders with MIR526B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR526B Gene

Publications for MIR526B Gene

  1. By downregulating PBX3, miR-526b suppresses the epithelial-mesenchymal transition process in cervical cancer cells. (PMID: 30859853) Li H … Yang Y (Future oncology (London, England) 2019) 3 54
  2. miR-526b targets 3' UTR of MMP1 mRNA. (PMID: 26292968) Kim KH … Lee TR (Experimental & molecular medicine 2015) 3 54
  3. By downregulating Ku80, hsa-miR-526b suppresses non-small cell lung cancer. (PMID: 25596743) Zhang ZY … Wei S (Oncotarget 2015) 3 54
  4. COX-2 Elevates Oncogenic miR-526b in Breast Cancer by EP4 Activation. (PMID: 25733698) Majumder M … Lala PK (Molecular cancer research : MCR 2015) 3 54
  5. The has-miR-526b binding-site rs8506G>a polymorphism in the lincRNA-NR_024015 exon identified by GWASs predispose to non-cardia gastric cancer risk. (PMID: 24595048) Fan QH … Zhang LY (PloS one 2014) 3 54

Products for MIR526B Gene

Sources for MIR526B Gene