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Aliases for MIR525 Gene

Subcategory (RNA class) for MIR525 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR525 Gene

  • MicroRNA 525 2 3 5
  • Hsa-Mir-525 3
  • MIRN525 3

External Ids for MIR525 Gene

ORGUL Members for MIR525 Gene

Previous HGNC Symbols for MIR525 Gene

  • MIRN525

Previous GeneCards Identifiers for MIR525 Gene

  • GC19U901003
  • GC19P059034
  • GC19P054200

Summaries for MIR525 Gene

Entrez Gene Summary for MIR525 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR525 Gene

MIR525 (MicroRNA 525) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR525 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR525 Gene

Genomics for MIR525 Gene

GeneHancer (GH) Regulatory Elements for MIR525 Gene

Promoters and enhancers for MIR525 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I053840 Enhancer 1.1 Ensembl ENCODE 10.5 +144.6 144596 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19I053659 Enhancer 0.9 ENCODE dbSUPER 11.1 -36.3 -36258 2.7 ELF3 SOX13 FOXA2 SAP130 NR2F6 CREM GATAD2A SOX5 SP5 PPARG MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19I053611 Enhancer 0.9 ENCODE dbSUPER 10.8 -84.6 -84568 3.1 SOX13 ESRRA USF1 FOXA2 NEUROD1 TEAD3 CTBP1 GATA3 POLR2A NR2F6 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C MIR526A1
GH19I053898 Enhancer 0.9 Ensembl ENCODE 10.6 +201.3 201309 1.3 KLF1 PKNOX1 BACH1 ZNF335 POLR2A PATZ1 PRDM10 KLF8 KLF13 SP3 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A RNU6-1041P MIR516A2 MIR519A1 RNU6-751P
GH19I053844 Enhancer 0.9 FANTOM5 Ensembl ENCODE 10.5 +147.6 147561 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR525 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR525 Gene

Genomic Locations for MIR525 Gene
chr19:53,697,533-53,697,617
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand
chr19:54,200,787-54,200,871
(GRCh37/hg19)

Genomic View for MIR525 Gene

Genes around MIR525 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR525 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR525 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR525 Gene

Proteins for MIR525 Gene

Post-translational modifications for MIR525 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR525 Gene

Domains & Families for MIR525 Gene

Gene Families for MIR525 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR525: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR525 Gene

Function for MIR525 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR525 Gene

Localization for MIR525 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR525 Gene

Pathways & Interactions for MIR525 Gene

SuperPathways for MIR525 Gene

No Data Available

Interacting Proteins for MIR525 Gene

Gene Ontology (GO) - Biological Process for MIR525 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR525 Gene

Drugs & Compounds for MIR525 Gene

No Compound Related Data Available

Transcripts for MIR525 Gene

mRNA/cDNA for MIR525 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR525 Gene

No ASD Table

Relevant External Links for MIR525 Gene

GeneLoc Exon Structure for
MIR525
ECgene alternative splicing isoforms for
MIR525

Expression for MIR525 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR525 Gene:

MIR525
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR525 Gene

Orthologs for MIR525 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR525 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-525 34
  • 96 (a)
OneToOne
Species where no ortholog for MIR525 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR525 Gene

ENSEMBL:
Gene Tree for MIR525 (if available)
TreeFam:
Gene Tree for MIR525 (if available)

Paralogs for MIR525 Gene

No data available for Paralogs for MIR525 Gene

Variants for MIR525 Gene

Sequence variations from dbSNP and Humsavar for MIR525 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1001528436 -- 53,696,656(+) T/C/G upstream_transcript_variant
rs1001975304 -- 53,696,352(+) T/C upstream_transcript_variant
rs1002123702 -- 53,696,734(+) G/C upstream_transcript_variant
rs1002260992 -- 53,696,954(+) T/C upstream_transcript_variant
rs1002596502 -- 53,697,993(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR525 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718834 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR525 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR525

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR525 Gene

Disorders for MIR525 Gene

Additional Disease Information for MIR525

No disorders were found for MIR525 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR525 Gene

Publications for MIR525 Gene

  1. High expression levels of microRNA-629, microRNA-525-5p and microRNA-516a-3p in paediatric systemic lupus erythematosus. (PMID: 24687380) Zhu J … Song G (Clinical rheumatology 2014) 3 58
  2. MiR-525-3p enhances the migration and invasion of liver cancer cells by downregulating ZNF395. (PMID: 24599008) Pang F … He X (PloS one 2014) 3 58
  3. Single nucleotide polymorphisms in the 3'UTR of VPAC-1 cooperate in modulating gene expression and impact differently on the interaction with miR525-5p. (PMID: 25390694) Paladini F … Sorrentino R (PloS one 2014) 3 58
  4. Cell survival following radiation exposure requires miR-525-3p mediated suppression of ARRB1 and TXN1. (PMID: 24147004) Kraemer A … Moertl S (PloS one 2013) 3 58
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58

Products for MIR525 Gene

Sources for MIR525 Gene

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