microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520H Gene

Subcategory (RNA class) for MIR520H Gene


Number of RNA Genes sources:

6 / 17

Aliases for MIR520H Gene

  • MicroRNA 520h 2 3 5
  • Hsa-Mir-520h 2 3
  • Hsa-MiR-520h 163 173
  • MIR520H 2 5
  • Hsa-Mir-430-P37a 178
  • MIMAT0002867 50
  • MI0003175 50
  • MIRN520H 3
  • RF00639 168

External Ids for MIR520H Gene

Previous HGNC Symbols for MIR520H Gene

  • MIRN520H

Previous GeneCards Identifiers for MIR520H Gene

  • GC19P058976
  • GC19P059019
  • GC19P054248
  • GC19P054252
  • GC19P054302
  • GC19P054329
  • GC19P054349
  • GC19P054421
  • GC19P054502
  • GC19P053744
  • GC19P053772
  • GC19P053992
  • GC19P054022
  • GC19P054047
  • GC19P054119
  • GC19P053806
  • GC19P053836
  • GC19P053857
  • GC19P053872
  • GC19P053884
  • GC19P053907
  • GC19P053933
  • GC19P053961

Summaries for MIR520H Gene

Entrez Gene Summary for MIR520H Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520H Gene

MIR520H (MicroRNA 520h) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR520H include Extragonadal Nonseminomatous Germ Cell Tumor and Breast Angiosarcoma. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR520H Gene

Additional gene information for MIR520H Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520H Gene

Genomics for MIR520H Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR520H Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053742 Enhancer 0.2 Ensembl 600.7 +0.2 189 0.2 MIR517C MIR520H RF00639-031 RNU6-982P NLRP12 DPRX
GH19J053656 Enhancer 1.1 Ensembl ENCODE dbSUPER 11 -82.2 -82218 6.6 GATAD2A CTCF KDM1A RCOR2 RXRB REST PBX2 SOX13 RFX3 TCF7 ENSG00000270347 LOC100288093 lnc-NLRP12-5 MIR515-2 MIR1283-1 MIR519C MIR520A RN7SL317P DPRX MIR519B
GH19J053787 Promoter/Enhancer 1 FANTOM5 Ensembl 12.1 +45.5 45489 2 NRF1 MGA CBX3 ZBTB11 GTF2A2 TBP CREM DIDO1 TAF7 ZBTB40 ENSG00000269564 ENSG00000269877 MIR371A MIR371B MIR372 MIR373 RNU6-1041P MIR1283-2 MIR516A2 MIR516A1
GH19J053611 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.8 -129.5 -129547 3.1 TEAD4 RCOR2 TARDBP RXRB SP1 POLR2A SOX13 TCF7 CTBP1 ZKSCAN8 MG828569 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C
GH19J053840 Enhancer 0.9 ENCODE 10.5 +99.7 99710 2.5 CREB1 GATAD2A CTCF PRDM10 ZNF629 SOX13 ZNF692 ETV6 JUND PRDM1 MYADM-AS1 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR520H on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR520H Gene

Genomic Locations for MIR520H Gene
88 bases
Plus strand
88 bases
Plus strand

Genomic View for MIR520H Gene

Genes around MIR520H on UCSC Golden Path with GeneCards custom track
MIR520H in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR520H Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520H Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520H Gene

Proteins for MIR520H Gene

Post-translational modifications for MIR520H Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520H Gene

Domains & Families for MIR520H Gene

Gene Families for MIR520H Gene

genes like me logo Genes that share domains with MIR520H: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520H Gene

Function for MIR520H Gene

Gene Ontology (GO) - Molecular Function for MIR520H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA, HDA 20190813
genes like me logo Genes that share ontologies with MIR520H: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520H Gene

Localization for MIR520H Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR520H gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520H Gene

Pathways & Interactions for MIR520H Gene

PathCards logo

SuperPathways for MIR520H Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520H: view

Pathways by source for MIR520H Gene

1 KEGG pathway for MIR520H Gene

Gene Ontology (GO) - Biological Process for MIR520H Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 20190813
GO:0035195 gene silencing by miRNA IDA, IEA, HDA --
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP 20190813
GO:1904046 negative regulation of vascular endothelial growth factor production HMP 18320040
genes like me logo Genes that share ontologies with MIR520H: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR520H Gene

Drugs & Compounds for MIR520H Gene

No Compound Related Data Available

Transcripts for MIR520H Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520H Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00006B6CC5_9606 precursor_RNA 88 5

HGNC: 32125,

RefSeq: NR_030215,

Ensembl: ENST00000385126 (view in UCSC) ,

miRBase: MI0003175,

Rfam: RF00639,

URS000059C31C_9606 miRNA 22 5

RefSeq: NR_030215,

LncBase: hsa-miR-520h,

miRBase: MIMAT0002867,

TarBase: hsa-miR-520h,

ENA: AY785928.1:1..22:ncRNA,

URS0000EFDBAC_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-430-P37a,

URS0000EFE891_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-430-P37a_5p, Hsa-Mir-430-P37b_5p,

URS0000EFEC23_9606 miRNA 21 1

MirGeneDB: Hsa-Mir-430-P37a_3p, Hsa-Mir-430-P37b_3p,

MIR520H in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR520H Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520H Gene

No ASD Table

Relevant External Links for MIR520H Gene

GeneLoc Exon Structure for

Expression for MIR520H Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520H

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520H Gene

Orthologs for MIR520H Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520H Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-520g 31
  • 94 (a)
Species where no ortholog for MIR520H was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR520H Gene

Gene Tree for MIR520H (if available)
Gene Tree for MIR520H (if available)

Paralogs for MIR520H Gene

No data available for Paralogs for MIR520H Gene

Variants for MIR520H Gene

Additional dbSNP identifiers (rs#s) for MIR520H Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR520H Gene

Variant ID Type Subtype PubMed ID
esv2448351 CNV deletion 19546169
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
esv2718838 CNV deletion 23290073
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520H Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520H Gene

Disorders for MIR520H Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR520H Gene - From: DISEASES

Disorder Aliases PubMed IDs
extragonadal nonseminomatous germ cell tumor
  • primary malignant extragonadal nonseminoma
breast angiosarcoma
  • hemangiosarcoma of the breast
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR520H: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR520H Gene

Publications for MIR520H Gene

  1. Abnormally high expression of POLD1, MCM2, and PLK4 promotes relapse of acute lymphoblastic leukemia. (PMID: 29768346) Li S … Zhang G (Medicine 2018) 3
  2. The activation of microRNA-520h-associated TGF-β1/c-Myb/Smad7 axis promotes epithelial ovarian cancer progression. (PMID: 30158641) Zhang J … Lin Y (Cell death & disease 2018) 3
  3. miR-520h is crucial for DAPK2 regulation and breast cancer progression. (PMID: 25982274) Su CM … Su JL (Oncogene 2016) 3
  4. Downregulation of histone deacetylase 1 by microRNA-520h contributes to the chemotherapeutic effect of doxorubicin. (PMID: 24316511) Shen Q … Wang X (FEBS letters 2014) 3
  5. A microRNA-520 mirSNP at the MMP2 gene influences susceptibility to endometriosis in Chinese women. (PMID: 23364396) Tsai EM … Juo SH (Journal of human genetics 2013) 3

Products for MIR520H Gene

Sources for MIR520H Gene