microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520G Gene

Data sources for MIR520G Gene:

RNA type for MIR520G Gene

miRNA

Aliases for MIR520G Gene

External Ids for MIR520G Gene

Previous HGNC Symbols for MIR520G Gene

  • MIRN520G

Previous GeneCards Identifiers for MIR520G Gene

  • GC19P058950
  • GC19P059009
  • GC19P054230
  • GC19P054243
  • GC19P054295
  • GC19P054325
  • GC19P054345
  • GC19P054416
  • GC19P054498

Summaries for MIR520G Gene

Entrez Gene Summary for MIR520G Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520G Gene

MIR520G (MicroRNA 520g) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR520G include Ependymoblastoma and Central Nervous System Primitive Neuroectodermal Neoplasm. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR520G Gene

Additional gene information for MIR520G Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520G Gene

Genomics for MIR520G Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR520G Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR520G on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR520G Gene

Latest Assembly
chr19:53,722,166-53,722,255
(GRCh38/hg38)
Size:
90 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,225,420-54,225,509
(GRCh37/hg19 by Entrez Gene)
Size:
90 bases
Orientation:
Plus strand

chr19:54,225,420-54,225,509
(GRCh37/hg19 by Ensembl)
Size:
90 bases
Orientation:
Plus strand

Genomic View for MIR520G Gene

Genes around MIR520G on UCSC Golden Path with GeneCards custom track
MIR520G in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR520G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520G Gene

Proteins for MIR520G Gene

Post-translational modifications for MIR520G Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520G Gene

Domains & Families for MIR520G Gene

Gene Families for MIR520G Gene

genes like me logo Genes that share domains with MIR520G: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520G Gene

Function for MIR520G Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520G Gene

Localization for MIR520G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR520G gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520G Gene

Pathways & Interactions for MIR520G Gene

PathCards logo

SuperPathways for MIR520G Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520G: view

Pathways by source for MIR520G Gene

1 KEGG pathway for MIR520G Gene

Gene Ontology (GO) - Biological Process for MIR520G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:1904046 negative regulation of vascular endothelial growth factor production HMP 18320040
genes like me logo Genes that share ontologies with MIR520G: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR520G Gene

Drugs & Compounds for MIR520G Gene

No Compound Related Data Available

Transcripts for MIR520G Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520G Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000068CB78_9606 pre_miRNA 90 5

RefSeq: NR_030206,

Ensembl: ENST00000385064 (view in UCSC) ,

miRBase: MI0003166,

Rfam: RF00639,

ENA: LM609485.1:1..90:precursor_RNA,

URS0000021D08_9606 miRNA 24 4

RefSeq: NR_030206,

miRBase: MIMAT0002858,

TarBase: hsa-miR-520g-3p,

ENA: AY785945.1:1..24:ncRNA, LM379790.1:1..24:ncRNA, LM609485.1:55..78:ncRNA,

URS000075EBEC_9606 miRNA 23 3

RefSeq: NR_030206,

miRBase: MIMAT0026611,

ENA: LM609485.1:17..39:ncRNA,

URS0000EFCF05_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-430-P37b,

URS0000EFE891_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-430-P37a_5p, Hsa-Mir-430-P37b_5p,

MIR520G in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR520G Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520G Gene

No ASD Table

Relevant External Links for MIR520G Gene

GeneLoc Exon Structure for
MIR520G

Expression for MIR520G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR520G Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520G

genes like me logo Genes that share expression patterns with MIR520G: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520G Gene

Orthologs for MIR520G Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520G Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520g 30
  • 98 (a)
OneToMany
Species where no ortholog for MIR520G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR520G Gene

ENSEMBL:
Gene Tree for MIR520G (if available)
TreeFam:
Gene Tree for MIR520G (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR520G

Paralogs for MIR520G Gene

No data available for Paralogs for MIR520G Gene

Variants for MIR520G Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR520G Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR520G Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520G
Leiden Open Variation Database (LOVD)
MIR520G

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520G Gene

Disorders for MIR520G Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR520G Gene - From: COP

Disorder Aliases PubMed IDs
ependymoblastoma
  • embryonal tumor with multilayered rosettes
central nervous system primitive neuroectodermal neoplasm
  • cpnet
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR520G

genes like me logo Genes that share disorders with MIR520G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR520G Gene

Publications for MIR520G Gene

  1. Tissue Factor Regulation by miR-520g in Primitive Neuronal Brain Tumor Cells: A Possible Link between Oncomirs and the Vascular Tumor Microenvironment. (PMID: 26687818) D'Asti E … Rak J (The American journal of pathology 2016) 2 3
  2. Elevated microRNA-520g in pre-eclampsia inhibits migration and invasion of trophoblasts. (PMID: 28292471) Jiang L … Li Q (Placenta 2017) 3
  3. MicroRNA-520g promotes epithelial ovarian cancer progression and chemoresistance via DAPK2 repression. (PMID: 27049921) Zhang J … Xi X (Oncotarget 2016) 3
  4. Study on the relationship between miR-520g and the development of breast cancer. (PMID: 26957267) Ren GB … Mao ZP (European review for medical and pharmacological sciences 2016) 3
  5. MicroRNA-520g confers drug resistance by regulating p21 expression in colorectal cancer. (PMID: 25616665) Zhang Y … Wang J (The Journal of biological chemistry 2015) 3

Products for MIR520G Gene

Sources for MIR520G Gene