microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520E Gene

Data sources for MIR520E Gene:

RNA type for MIR520E Gene

miRNA

Aliases for MIR520E Gene

External Ids for MIR520E Gene

Previous HGNC Symbols for MIR520E Gene

  • MIRN520E

Previous GeneCards Identifiers for MIR520E Gene

  • GC19P058872
  • GC19P054180
  • GC19P054404
  • GC19P054481
  • GC19P053676
  • GC19P053683
  • GC19P053972
  • GC19P054005
  • GC19P054032
  • GC19P054091
  • GC19P053692
  • GC19P053723
  • GC19P053763
  • GC19P053794
  • GC19P053829
  • GC19P053881
  • GC19P053918
  • GC19P053947
  • GC19P054609
  • GC19P055558

Summaries for MIR520E Gene

Entrez Gene Summary for MIR520E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520E Gene

MIR520E (MicroRNA 520e) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR520E Gene

Additional gene information for MIR520E Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520E Gene

Genomics for MIR520E Gene

Genomic Locations for MIR520E Gene

Latest Assembly
chr19:53,675,711-53,675,797
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,178,965-54,179,051
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Plus strand

chr19:54,178,965-54,179,051
(GRCh37/hg19 by Ensembl)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR520E Gene

Genes around MIR520E on UCSC Golden Path with GeneCards custom track
MIR520E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR520E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520E Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR520E Gene

Proteins for MIR520E Gene

Post-translational modifications for MIR520E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520E Gene

Domains & Families for MIR520E Gene

Gene Families for MIR520E Gene

genes like me logo Genes that share domains with MIR520E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520E Gene

Function for MIR520E Gene

Gene Ontology (GO) - Molecular Function for MIR520E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20574151
genes like me logo Genes that share ontologies with MIR520E: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520E Gene

Localization for MIR520E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR520E gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520E Gene

Pathways & Interactions for MIR520E Gene

PathCards logo

SuperPathways for MIR520E Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520E: view

Pathways by source for MIR520E Gene

1 KEGG pathway for MIR520E Gene

Gene Ontology (GO) - Biological Process for MIR520E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 20574151
GO:0045958 positive regulation of complement activation, alternative pathway IDA 20574151
GO:2000010 positive regulation of protein localization to cell surface IDA 20574151
genes like me logo Genes that share ontologies with MIR520E: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR520E Gene

Drugs & Compounds for MIR520E Gene

No Compound Related Data Available

Transcripts for MIR520E Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520E Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00006EE977_9606 pre_miRNA 87 4

RefSeq: NR_030183,

Ensembl: ENST00000384867 (view in UCSC) ,

miRBase: MI0003143,

Rfam: RF00639,

URS00001A5F54_9606 miRNA 21 4

RefSeq: NR_030183,

miRBase: MIMAT0002825,

TarBase: hsa-miR-520e,

ENA: AY882267.1:1..21:ncRNA,

URS0000D4F992_9606 miRNA 22 2

RefSeq: NR_030183,

miRBase: MIMAT0037324,

URS0001BC41DF_9606 pre_miRNA 87 1

Rfam: RF00639,

URS0000EFF07F_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-430-P35,

MIR520E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR520E Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520E Gene

No ASD Table

Relevant External Links for MIR520E Gene

GeneLoc Exon Structure for
MIR520E

Expression for MIR520E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR520E Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520E

genes like me logo Genes that share expression patterns with MIR520E: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520E Gene

Orthologs for MIR520E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520e 30
  • 100 (a)
OneToOne
Species where no ortholog for MIR520E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR520E Gene

ENSEMBL:
Gene Tree for MIR520E (if available)
TreeFam:
Gene Tree for MIR520E (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR520E

Paralogs for MIR520E Gene

No data available for Paralogs for MIR520E Gene

Variants for MIR520E Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR520E Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR520E Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv1055718 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781

Additional Variant Information for MIR520E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520E
Leiden Open Variation Database (LOVD)
MIR520E

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520E Gene

Disorders for MIR520E Gene

Additional Disease Information for MIR520E

No disorders were found for MIR520E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520E Gene

Publications for MIR520E Gene

  1. MicroRNA-520e restricts the proliferation and invasion of glioma cells through the downregulation of Wnt/β-catenin signaling by targeting fibroblast growth factor 19. (PMID: 30826062) Zhang L … Wei M (Biochemical and biophysical research communications 2019) 3
  2. Influence of miR-520e-mediated MAPK signalling pathway on HBV replication and regulation of hepatocellular carcinoma cells via targeting EphA2. (PMID: 30521133) Tian JH … Li YJ (Journal of viral hepatitis 2019) 3
  3. MicroRNA-520e suppresses non-small-cell lung cancer cell growth by targeting Zbtb7a-mediated Wnt signaling pathway. (PMID: 28242196) Zhijun Z … Jingkang H (Biochemical and biophysical research communications 2017) 3
  4. MiR-520b/e Regulates Proliferation and Migration by Simultaneously Targeting EGFR in Gastric Cancer. (PMID: 27997901) Li S … Ba Y (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016) 3
  5. Selective microRNA-Offset RNA expression in human embryonic stem cells. (PMID: 25822230) Asikainen S … Hovatta O (PloS one 2015) 3

Products for MIR520E Gene

Sources for MIR520E Gene