Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR520E (MicroRNA 520e) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20574151 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IEA | -- |
GO:0035278 | miRNA mediated inhibition of translation | IDA | 20574151 |
GO:0045958 | positive regulation of complement activation, alternative pathway | IDA | 20574151 |
GO:2000010 | positive regulation of protein localization to cell surface | IDA | 20574151 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS00006EE977_9606 | precursor_RNA | 87 | 5 |
HGNC: 32093, RefSeq: NR_030183, Ensembl: ENST00000384867 (view in UCSC) , miRBase: MI0003143, Rfam: RF00639, |
URS00001A5F54_9606 | miRNA | 21 | 4 |
RefSeq: NR_030183, miRBase: MIMAT0002825, TarBase: hsa-miR-520e, ENA: AY882267.1:1..21:ncRNA, |
URS0000D4F992_9606 | miRNA | 22 | 2 |
RefSeq: NR_030183, miRBase: MIMAT0037324, |
URS0000EFF07F_9606 | precursor_RNA | 62 | 1 |
MirGeneDB: Hsa-Mir-430-P35, |
URS0000EFD3A8_9606 | miRNA | 22 | 1 |
MirGeneDB: Hsa-Mir-430-P35_3p, |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-520e 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2718812 | CNV | deletion | 23290073 |
esv2762049 | CNV | gain | 21179565 |
nsv1055718 | CNV | gain | 25217958 |
nsv458781 | CNV | gain | 19166990 |
nsv580107 | CNV | gain | 21841781 |
nsv580108 | CNV | gain | 21841781 |
No disorders were found for MIR520E Gene.