microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520D Gene

RNA type for MIR520D Gene

miRNA

Aliases for MIR520D Gene

External Ids for MIR520D Gene

Previous HGNC Symbols for MIR520D Gene

  • MIRN520D

Previous GeneCards Identifiers for MIR520D Gene

  • GC19P058944
  • GC19P059007
  • GC19P054228
  • GC19P054236
  • GC19P054272
  • GC19P054321
  • GC19P054342
  • GC19P054413
  • GC19P054488

Summaries for MIR520D Gene

Entrez Gene Summary for MIR520D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520D Gene

MIR520D (MicroRNA 520d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR520D include Benign Teratoma and Female Reproductive System Disease.

Rfam classification for MIR520D Gene

Additional gene information for MIR520D Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520D Gene

Genomics for MIR520D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR520D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR520D on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR520D Gene

Latest Assembly
chr19:53,720,096-53,720,182
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,223,350-54,223,436
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Plus strand

chr19:54,223,350-54,223,436
(GRCh37/hg19 by Ensembl)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR520D Gene

Genes around MIR520D on UCSC Golden Path with GeneCards custom track
MIR520D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR520D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520D Gene

Proteins for MIR520D Gene

Post-translational modifications for MIR520D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520D Gene

Domains & Families for MIR520D Gene

Gene Families for MIR520D Gene

genes like me logo Genes that share domains with MIR520D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520D Gene

Function for MIR520D Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520D Gene

Localization for MIR520D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR520D gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520D Gene

Pathways & Interactions for MIR520D Gene

PathCards logo

SuperPathways for MIR520D Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR520D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR520D: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR520D Gene

Drugs & Compounds for MIR520D Gene

No Compound Related Data Available

Transcripts for MIR520D Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520D Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00006A9A0F_9606 pre_miRNA 87 4

RefSeq: NR_030204,

Ensembl: ENST00000385002 (view in UCSC) ,

miRBase: MI0003164,

Rfam: RF00639,

URS000075D962_9606 miRNA 22 4

RefSeq: NR_030204,

miRBase: MIMAT0002856,

MirGeneDB: Hsa-Mir-430-P34_3p,

TarBase: hsa-miR-520d-3p,

URS00002A037E_9606 miRNA 20 4

RefSeq: NR_030204,

LncBase: hsa-miR-520d-5p,

miRBase: MIMAT0002855,

TarBase: hsa-miR-520d-5p,

URS000019784B_9606 miRNA 21 2

MirGeneDB: Hsa-Mir-430-P34_5p,

ENA: AY882290.1:1..21:ncRNA,

URS0000EFD756_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-430-P34,

MIR520D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR520D Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520D Gene

No ASD Table

Relevant External Links for MIR520D Gene

GeneLoc Exon Structure for
MIR520D

Expression for MIR520D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR520D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520D

genes like me logo Genes that share expression patterns with MIR520D: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520D Gene

Orthologs for MIR520D Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520d 30
  • 99 (a)
OneToOne
Species where no ortholog for MIR520D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR520D Gene

ENSEMBL:
Gene Tree for MIR520D (if available)
TreeFam:
Gene Tree for MIR520D (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR520D

Paralogs for MIR520D Gene

No data available for Paralogs for MIR520D Gene

Variants for MIR520D Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR520D Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR520D Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520D
Leiden Open Variation Database (LOVD)
MIR520D

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520D Gene

Disorders for MIR520D Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR520D Gene - From: COP

Disorder Aliases PubMed IDs
benign teratoma
  • dermoid cyst
female reproductive system disease
  • genital diseases, female
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR520D

genes like me logo Genes that share disorders with MIR520D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR520D Gene

Publications for MIR520D Gene

  1. MiR-520d-5p functions as a tumor-suppressor gene in cervical cancer through targeting PTK2. (PMID: 32198053) Zhang L … Zhang D (Life sciences 2020) 3
  2. Deregulation of miR-520d-3p promotes hepatocellular carcinoma development via lncRNA MIAT regulation and EPHA2 signaling activation. (PMID: 30551417) Xiang Y … Zhang J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019) 3
  3. miR-520d-5p can reduce the mutations in hepatoma cancer cells and iPSCs-derivatives. (PMID: 31202279) Miura N … Miura K (BMC cancer 2019) 3
  4. Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability. (PMID: 31615875) Achuthankutty D … Mailand N (The Journal of cell biology 2019) 3
  5. Elevated microRNA-520d-5p in the serum of patients with Parkinson's disease, possibly through regulation of cereloplasmin expression. (PMID: 30243884) Jin L … Zhong C (Neuroscience letters 2018) 3

Products for MIR520D Gene

Sources for MIR520D Gene