MIR520C Gene (RNA Gene)

MicroRNA 520c

GC19P055941
GIFtS:
18
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520C Gene

Data sources for MIR520C Gene:

RNA type for MIR520C Gene

miRNA

Aliases for MIR520C Gene

External Ids for MIR520C Gene

Previous HGNC Symbols for MIR520C Gene

  • MIRN520C

Previous GeneCards Identifiers for MIR520C Gene

  • GC19P058930
  • GC19P059001
  • GC19P054210
  • GC19P053708
  • GC19P053737
  • GC19P053985
  • GC19P054016
  • GC19P054041
  • GC19P054106
  • GC19P053769
  • GC19P053803
  • GC19P053839
  • GC19P053848
  • GC19P053874
  • GC19P053854
  • GC19P053910
  • GC19P053957
  • GC19P054624
  • GC19P055569

Summaries for MIR520C Gene

Entrez Gene Summary for MIR520C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520C Gene

MIR520C (MicroRNA 520c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR520C include Breast Cancer and Estrogen-Receptor Negative Breast Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR520C Gene

Additional gene information for MIR520C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520C Gene

Genomics for MIR520C Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIR520C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR520C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR520C Gene

Latest Assembly
chr19:53,707,453-53,707,539
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,210,707-54,210,793
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Plus strand

chr19:54,210,707-54,210,793
(GRCh37/hg19 by Ensembl)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR520C Gene

Genes around MIR520C on UCSC Golden Path with GeneCards custom track
MIR520C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR520C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520C Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR520C Gene

Proteins for MIR520C Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

Post-translational modifications for MIR520C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520C Gene

Domains & Families for MIR520C Gene

Gene Families for MIR520C Gene

HGNC:
genes like me logo Genes that share domains with MIR520C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520C Gene

Function for MIR520C Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for MIR520C Gene

Gene Ontology (GO) - Molecular Function for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 18684319
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18684319
genes like me logo Genes that share ontologies with MIR520C: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520C Gene

Localization for MIR520C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR520C gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520C Gene

Pathways & Interactions for MIR520C Gene

PathCards logo

SuperPathways for MIR520C Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR520C: view

Pathways by source for MIR520C Gene

1 KEGG pathway for MIR520C Gene

Gene Ontology (GO) - Biological Process for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IDA 29048659
GO:0010561 negative regulation of glycoprotein biosynthetic process IDA 29048659
GO:0010628 positive regulation of gene expression IDA 29048659
GO:0010629 negative regulation of gene expression IDA 29048659
GO:0031327 negative regulation of cellular biosynthetic process IDA 29048659
genes like me logo Genes that share ontologies with MIR520C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR520C Gene

Drugs & Compounds for MIR520C Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for MIR520C Gene

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  3. Inhibitory RNAs for research
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Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520C Gene

GeneCaRNA:The Human ncRNA Database 2021 Publication

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000049A7EB_9606 miRNA 22 6

RefSeq: NR_030198,

LncBase: hsa-miR-520c-3p,

miRBase: MIMAT0002846,

MirGeneDB: Hsa-Mir-430-P32_3p, Hsa-Mir-430-P33_3p,

TarBase: hsa-miR-520c-3p,

ENA: AY785927.1:1..22:ncRNA,

URS0000087207_9606 miRNA 22 5

RefSeq: NR_030197, NR_030198, NR_030208, NR_030211,

LncBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a,

miRBase: MIMAT0005455,

MirGeneDB: Hsa-Mir-430-P22_5p, Hsa-Mir-430-P45_5p, Hsa-Mir-430-P46_5p,

TarBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a,

URS00006F562E_9606 pre_miRNA 87 4

RefSeq: NR_030198,

Ensembl: ENST00000385005 (view in UCSC) ,

miRBase: MI0003158,

Rfam: RF00639,

URS000041D720_9606 miRNA 21 2

MirGeneDB: Hsa-Mir-430-P33_5p,

ENA: AY882336.1:1..21:ncRNA,

URS0000EFCB55_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-430-P33,

MIR520C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

CRISPR products for research

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520C Gene

No ASD Table

Relevant External Links for MIR520C Gene

GeneLoc Exon Structure for
MIR520C

No data available for mRNA/cDNA for MIR520C Gene

Expression for MIR520C Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR520C Gene

mRNA expression in normal human tissues for MIR520C Gene
mRNA expression by GTEx for MIR520C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520C

genes like me logo Genes that share expression patterns with MIR520C: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520C Gene

Orthologs for MIR520C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-520c 30
  • 100 (a)
 OneToOne
Species where no ortholog for MIR520C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR520C Gene

ENSEMBL:
Gene Tree for MIR520C (if available)
TreeFam:
Gene Tree for MIR520C (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR520C

Paralogs for MIR520C Gene

No data available for Paralogs for MIR520C Gene

Variants for MIR520C Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR520C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR520C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520C
Leiden Open Variation Database (LOVD)
MIR520C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520C Gene

Disorders for MIR520C Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR520C Gene - From: MID, COP, and GCD

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, familial
estrogen-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR520C

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR520C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR520C Gene

Publications for MIR520C Gene

  1. LncRNA TPTE2P1 promotes the proliferation of thyroid carcinoma by inhibiting miR-520c-3p. (PMID: 31144790) Peng L … Wan F (Panminerva medica 2020) 3
  2. MicroRNA-520c-3p functions as a novel tumor suppressor in lung adenocarcinoma. (PMID: 30942957) Li X … Yu X (The FEBS journal 2019) 3
  3. microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3. (PMID: 31143973) Liu Z … Wang P (Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019) 3
  4. Long non-coding RNA HOXA-AS2 promotes migration and invasion by acting as a ceRNA of miR-520c-3p in osteosarcoma cells. (PMID: 30081707) Wang Y … Han X (Cell cycle (Georgetown, Tex.) 2018) 3
  5. MicroRNA-520c-3p negatively regulates EMT by targeting IL-8 to suppress the invasion and migration of breast cancer. (PMID: 29048659) Tang CP … Zhang T (Oncology reports 2017) 3

ExternalLinks

View latest publications for MIR520C gene in Mastermind

Products for MIR520C Gene

Sources for MIR520C Gene