microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520C Gene

Subcategory (RNA class) for MIR520C Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR520C Gene

  • Hsa-Mir-430-P33 178
  • MIMAT0005455 50
  • MIMAT0005456 50
  • MIMAT0002846 50
  • MIMAT0002845 50
  • MI0003158 50
  • MIRN520C 3
  • RF00639 168

External Ids for MIR520C Gene

Previous HGNC Symbols for MIR520C Gene

  • MIRN520C

Previous GeneCards Identifiers for MIR520C Gene

  • GC19P058930
  • GC19P059001
  • GC19P054210
  • GC19P053708
  • GC19P053737
  • GC19P053985
  • GC19P054016
  • GC19P054041
  • GC19P054106
  • GC19P053769
  • GC19P053803
  • GC19P053839
  • GC19P053848
  • GC19P053874
  • GC19P053854
  • GC19P053910
  • GC19P053957

Summaries for MIR520C Gene

Entrez Gene Summary for MIR520C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520C Gene

MIR520C (MicroRNA 520c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR520C include Breast Cancer and Estrogen-Receptor Negative Breast Cancer. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR520C Gene

Additional gene information for MIR520C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520C Gene

Genomics for MIR520C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR520C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR520C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR520C Gene

Genomic Locations for MIR520C Gene
chr19:53,707,453-53,707,539
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr19:54,210,707-54,210,793
(GRCh37/hg19)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR520C Gene

Genes around MIR520C on UCSC Golden Path with GeneCards custom track
MIR520C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR520C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520C Gene

Proteins for MIR520C Gene

Post-translational modifications for MIR520C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520C Gene

Domains & Families for MIR520C Gene

Gene Families for MIR520C Gene

genes like me logo Genes that share domains with MIR520C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520C Gene

Function for MIR520C Gene

Gene Ontology (GO) - Molecular Function for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003730 mRNA 3'-UTR binding IDA 18684319
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18684319
genes like me logo Genes that share ontologies with MIR520C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520C Gene

Localization for MIR520C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR520C gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
endosome 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR520C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR520C Gene

Pathways & Interactions for MIR520C Gene

PathCards logo

SuperPathways for MIR520C Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520C: view

Pathways by source for MIR520C Gene

1 KEGG pathway for MIR520C Gene

Gene Ontology (GO) - Biological Process for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001960 negative regulation of cytokine-mediated signaling pathway IDA 29048659
GO:0010561 negative regulation of glycoprotein biosynthetic process IDA 29048659
GO:0010628 positive regulation of gene expression IDA 29048659
GO:0010629 negative regulation of gene expression IDA 29048659
GO:0031327 negative regulation of cellular biosynthetic process IDA 29048659
genes like me logo Genes that share ontologies with MIR520C: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR520C Gene

Drugs & Compounds for MIR520C Gene

No Compound Related Data Available

Transcripts for MIR520C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520C Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000049A7EB_9606 miRNA 22 6

RefSeq: NR_030198,

LncBase: hsa-miR-520c-3p,

miRBase: MIMAT0002846,

MirGeneDB: Hsa-Mir-430-P32_3p, Hsa-Mir-430-P33_3p,

TarBase: hsa-miR-520c-3p,

ENA: AY785927.1:1..22:ncRNA,

URS00006F562E_9606 precursor_RNA 87 5

HGNC: 32108,

RefSeq: NR_030198,

Ensembl: ENST00000385005 (view in UCSC) ,

miRBase: MI0003158,

Rfam: RF00639,

URS0000087207_9606 miRNA 22 5

RefSeq: NR_030197, NR_030198, NR_030208, NR_030211,

LncBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a,

miRBase: MIMAT0002845, MIMAT0005455, MIMAT0005456,

MirGeneDB: Hsa-Mir-430-P22_5p, Hsa-Mir-430-P45_5p, Hsa-Mir-430-P46_5p,

TarBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a,

URS000041D720_9606 miRNA 21 2

MirGeneDB: Hsa-Mir-430-P33_5p,

ENA: AY882336.1:1..21:ncRNA,

URS0000EFCB55_9606 precursor_RNA 61 1

MirGeneDB: Hsa-Mir-430-P33,

MIR520C in the GeneCards ncRNA compendium hub on the UCSC Golden Path

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520C Gene

No ASD Table

Relevant External Links for MIR520C Gene

GeneLoc Exon Structure for
MIR520C

No data available for mRNA/cDNA for MIR520C Gene

Expression for MIR520C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR520C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520C

genes like me logo Genes that share expression patterns with MIR520C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520C Gene

Orthologs for MIR520C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520c 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR520C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR520C Gene

ENSEMBL:
Gene Tree for MIR520C (if available)
TreeFam:
Gene Tree for MIR520C (if available)

Paralogs for MIR520C Gene

No data available for Paralogs for MIR520C Gene

Variants for MIR520C Gene

Additional dbSNP identifiers (rs#s) for MIR520C Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR520C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520C Gene

Disorders for MIR520C Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR520C Gene - From: miR2Disease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast lobular carcinoma
estrogen-receptor negative breast cancer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR520C

genes like me logo Genes that share disorders with MIR520C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR520C Gene

Publications for MIR520C Gene

  1. MicroRNA-520c-3p functions as a novel tumor suppressor in lung adenocarcinoma. (PMID: 30942957) Li X … Yu X (The FEBS journal 2019) 3
  2. microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3. (PMID: 31143973) Liu Z … Wang P (Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019) 3
  3. Long non-coding RNA HOXA-AS2 promotes migration and invasion by acting as a ceRNA of miR-520c-3p in osteosarcoma cells. (PMID: 30081707) Wang Y … Han X (Cell cycle (Georgetown, Tex.) 2018) 3
  4. MicroRNA-520c-3p negatively regulates EMT by targeting IL-8 to suppress the invasion and migration of breast cancer. (PMID: 29048659) Tang CP … Zhang T (Oncology reports 2017) 3
  5. Long non-coding RNA HOXA-AS2 promotes proliferation and invasion of breast cancer by acting as a miR-520c-3p sponge. (PMID: 28545023) Fang Y … Zhang Q (Oncotarget 2017) 3

Products for MIR520C Gene

Sources for MIR520C Gene