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MIR520C Gene(RNA Gene)

MicroRNA 520c

GCID:
GC19P053854
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR520C Gene

Subcategory (RNA class) for MIR520C Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR520C Gene

  • MicroRNA 520c 2 3 5
  • Hsa-Mir-520c 3
  • MIRN520C 3

External Ids for MIR520C Gene

ORGUL Members for MIR520C Gene

Previous HGNC Symbols for MIR520C Gene

  • MIRN520C

Previous GeneCards Identifiers for MIR520C Gene

  • GC19P058930
  • GC19P059001
  • GC19P054210
  • GC19P053708
  • GC19P053737
  • GC19P053769
  • GC19P053803
  • GC19P053839
  • GC19P053848
  • GC19P053874

Summaries for MIR520C Gene

Entrez Gene Summary for MIR520C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520C Gene

MIR520C (MicroRNA 520c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR520C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR520C Gene

Genomics for MIR520C Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR520C Gene

Promoters and enhancers for MIR520C Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I053840 Enhancer 1.1 Ensembl ENCODE 10.5 +134.7 134676 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19I053659 Enhancer 0.9 ENCODE dbSUPER 11.1 -46.2 -46178 2.7 ELF3 SOX13 FOXA2 SAP130 NR2F6 CREM GATAD2A SOX5 SP5 PPARG MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19I053611 Enhancer 0.9 ENCODE dbSUPER 10.8 -94.5 -94488 3.1 SOX13 ESRRA USF1 FOXA2 NEUROD1 TEAD3 CTBP1 GATA3 POLR2A NR2F6 MIR520A RNU6-698P MIR519B MIR525 MIR526B MIR518B MIR518F MIR520B MIR520C MIR526A1
GH19I053898 Enhancer 0.9 Ensembl ENCODE 10.6 +191.4 191389 1.3 KLF1 PKNOX1 BACH1 ZNF335 POLR2A PATZ1 PRDM10 KLF8 KLF13 SP3 LOC105372457 ENSG00000232324 MYADM MIR935 CACNG6 MIR520A RNU6-1041P MIR516A2 MIR519A1 RNU6-751P
GH19I053844 Enhancer 0.9 FANTOM5 Ensembl ENCODE 10.5 +137.6 137641 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR520C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR520C Gene

Genomic Locations for MIR520C Gene
chr19:53,707,453-53,707,539
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr19:54,210,707-54,210,793
(GRCh37/hg19)

Genomic View for MIR520C Gene

Genes around MIR520C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR520C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520C Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR520C Gene

Proteins for MIR520C Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR520C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520C Gene

Domains & Families for MIR520C Gene

Gene Families for MIR520C Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR520C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR520C Gene

Function for MIR520C Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 24639097
genes like me logo Genes that share ontologies with MIR520C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520C Gene

Localization for MIR520C Gene

Gene Ontology (GO) - Cellular Components for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR520C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR520C Gene

Pathways & Interactions for MIR520C Gene

SuperPathways for MIR520C Gene

PathCards logo More details on SuperPathways for MIR520C
SuperPathway Contained pathways
1 MicroRNAs in cancer
MicroRNAs in cancer
-
genes like me logo Genes that share pathways with MIR520C: view

Pathways by source for MIR520C Gene

1 KEGG pathway for MIR520C Gene

Interacting Proteins for MIR520C Gene

Gene Ontology (GO) - Biological Process for MIR520C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 24639097
genes like me logo Genes that share ontologies with MIR520C: view

No data available for SIGNOR curated interactions for MIR520C Gene

Drugs & Compounds for MIR520C Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR520C Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR520C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520C Gene

No ASD Table

Relevant External Links for MIR520C Gene

GeneLoc Exon Structure for
MIR520C
ECgene alternative splicing isoforms for
MIR520C

Expression for MIR520C Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR520C Gene

mRNA expression in normal human tissues for MIR520C Gene
mRNA expression by GTEx for MIR520C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR520C Gene:

MIR520C
genes like me logo Genes that share expression patterns with MIR520C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520C Gene

Orthologs for MIR520C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-520c 34
  • 100 (a)
 OneToOne
Species where no ortholog for MIR520C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520C Gene

ENSEMBL:
Gene Tree for MIR520C (if available)
TreeFam:
Gene Tree for MIR520C (if available)

Paralogs for MIR520C Gene

No data available for Paralogs for MIR520C Gene

Variants for MIR520C Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for MIR520C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000385722 -- 53,707,154(+) A/G upstream_transcript_variant
rs1002041166 -- 53,706,078(+) T/A upstream_transcript_variant
rs1002820702 -- 53,705,907(+) A/T upstream_transcript_variant
rs1003664802 -- 53,706,803(+) A/G upstream_transcript_variant
rs1003718699 -- 53,707,113(+) T/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR520C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR520C Gene

Disorders for MIR520C Gene

Additional Disease Information for MIR520C

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR520C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520C Gene

Publications for MIR520C Gene

  1. MicroRNA-520c inhibits glioma cell migration and invasion by the suppression of transforming growth factor-β receptor type 2. (PMID: 28184932) Hu S … Luo J (Oncology reports 2017) 3 58
  2. Epigenetic silencing of miR-520c leads to induced S100A4 expression and its mediated colorectal cancer progression. (PMID: 28423501) Mudduluru G … Stein U (Oncotarget 2017) 3 58
  3. Dual-Functions of miR-373 and miR-520c by Differently Regulating the Activities of MMP2 and MMP9. (PMID: 25545756) Lu S … Liu P (Journal of cellular physiology 2015) 3 58
  4. Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells. (PMID: 26208390) Fomeshi MR … Khayatzadeh H (Cellular & molecular biology letters 2015) 3 58
  5. Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development. (PMID: 24497838) Mazan-Mamczarz K … Gartenhaus RB (PLoS genetics 2014) 3 58

Products for MIR520C Gene

Sources for MIR520C Gene

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