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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...
Aliases for MIR520C Gene
Subcategory (RNA class) for MIR520C Gene
miRNA
Aliases for MIR520C Gene
External Ids for MIR520C Gene
- HGNC: 32108
- NCBI Entrez Gene: 574476
- Ensembl: ENSG00000207738
- OMIM®: 615908
- miRBase: hsa-mir-520c
Previous HGNC Symbols for MIR520C Gene
- MIRN520C
Previous GeneCards Identifiers for MIR520C Gene
- GC19P058930
- GC19P059001
- GC19P054210
- GC19P053708
- GC19P053737
- GC19P053985
- GC19P054016
- GC19P054041
- GC19P054106
- GC19P053769
- GC19P053803
- GC19P053839
- GC19P053848
- GC19P053874
- GC19P053854
- GC19P053910
- GC19P053957
- GC19P054624
Summaries for MIR520C Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR520C Gene
MIR520C (MicroRNA 520c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR520C include Breast Cancer and Estrogen-Receptor Negative Breast Cancer. Among its related pathways are MicroRNAs in cancer.
Rfam classification for MIR520C Gene
-
microRNA mir-515
Additional gene information for MIR520C Gene
No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520C Gene
Genomics for MIR520C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIR520C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIR520C on the GeneHancer Hub at the UCSC Golden Path
Genomic Locations for MIR520C Gene
Latest Assembly
- chr19:53,707,453-53,707,539
- (GRCh38/hg38)
- Size:
- 87 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:54,210,707-54,210,793
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 87 bases
- Orientation:
- Plus strand
- chr19:54,210,707-54,210,793
- (GRCh37/hg19 by Ensembl)
- Size:
- 87 bases
- Orientation:
- Plus strand
Genomic View for MIR520C Gene
Genes around MIR520C on UCSC Golden Path with GeneCards custom track
MIR520C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 19q13.42 by HGNC
- 19q13.42 by Entrez Gene
- 19q13.42 by Ensembl
MIR520C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR520C Gene
Proteins for MIR520C Gene
Post-translational modifications for MIR520C Gene
No Post-translational modifications
No data available for DME Specific Peptides for MIR520C Gene
Domains & Families for MIR520C Gene
Gene Families for MIR520C Gene
- HGNC:
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520C Gene
Function for MIR520C Gene
Phenotypes From GWAS Catalog for MIR520C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003730 | mRNA 3'-UTR binding | IDA | 18684319 |
| GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 18684319 |
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR520C - Starting at $85 >
- * MIR520C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR520C - Starting at $45 >
- * MIR520C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520C Gene
Localization for MIR520C Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520C Gene
Pathways & Interactions for MIR520C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | MicroRNAs in cancer | ||
Pathways by source for MIR520C Gene
1 KEGG pathway for MIR520C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001960 | negative regulation of cytokine-mediated signaling pathway | IDA | 29048659 |
| GO:0010561 | negative regulation of glycoprotein biosynthetic process | IDA | 29048659 |
| GO:0010628 | positive regulation of gene expression | IDA | 29048659 |
| GO:0010629 | negative regulation of gene expression | IDA | 29048659 |
| GO:0031327 | negative regulation of cellular biosynthetic process | IDA | 29048659 |
No data available for Interacting Proteins and SIGNOR curated interactions for MIR520C Gene
Transcripts for MIR520C Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520C Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS000049A7EB_9606 | miRNA | 22 | 6 |
RefSeq: NR_030198, LncBase: hsa-miR-520c-3p, miRBase: MIMAT0002846, MirGeneDB: Hsa-Mir-430-P32_3p, Hsa-Mir-430-P33_3p, TarBase: hsa-miR-520c-3p, ENA: AY785927.1:1..22:ncRNA, |
| URS0000087207_9606 | miRNA | 22 | 5 |
RefSeq: NR_030197, NR_030198, NR_030208, NR_030211, LncBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a, miRBase: MIMAT0005455, MirGeneDB: Hsa-Mir-430-P22_5p, Hsa-Mir-430-P45_5p, Hsa-Mir-430-P46_5p, TarBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a, |
| URS00006F562E_9606 | precursor_RNA | 87 | 4 |
RefSeq: NR_030198, Ensembl: ENST00000385005 (view in UCSC) , miRBase: MI0003158, Rfam: RF00639, |
| URS000041D720_9606 | miRNA | 21 | 2 |
MirGeneDB: Hsa-Mir-430-P33_5p, ENA: AY882336.1:1..21:ncRNA, |
| URS0000EFCB55_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-430-P33, |
MIR520C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MIR520C - Starting at $85 >
- * MIR520C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
Inhibitory RNAs for research
Clone products for research
- Applied Biological Materials (abm): Clones for MIR520C - Starting at $45 >
- * MIR520C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
Relevant External Links for MIR520C Gene
- GeneLoc Exon Structure for
- MIR520C
No data available for mRNA/cDNA for MIR520C Gene
Expression for MIR520C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520C
Primer products for research
-
OriGene qPCR primer pairs for MIR520C
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520C Gene
Orthologs for MIR520C Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-520c 31 |
|
OneToOne |
- Species where no ortholog for MIR520C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for MIR520C Gene
No data available for Paralogs for MIR520C Gene
Variants for MIR520C Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2718812 | CNV | deletion | 23290073 |
| esv2718833 | CNV | deletion | 23290073 |
| esv2718836 | CNV | deletion | 23290073 |
| esv2762049 | CNV | gain | 21179565 |
| nsv458781 | CNV | gain | 19166990 |
| nsv580107 | CNV | gain | 21841781 |
| nsv580108 | CNV | gain | 21841781 |
| nsv961246 | CNV | duplication | 23825009 |
Additional Variant Information for MIR520C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR520C
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520C Gene
Disorders for MIR520C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| breast cancer |
|
|
| estrogen-receptor negative breast cancer |
|
|
| trichorhinophalangeal syndrome, type i |
|
|
Search MIR520C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIR520C
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR520C Gene
Publications for MIR520C Gene
- LncRNA TPTE2P1 promotes the proliferation of thyroid carcinoma by inhibiting miR-520c-3p. (PMID: 31144790) Peng L … Wan F (Panminerva medica 2020) 3
- microRNA-520c-3p suppresses NLRP3 inflammasome activation and inflammatory cascade in preeclampsia by downregulating NLRP3. (PMID: 31143973) Liu Z … Wang P (Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2019) 3
- MicroRNA-520c-3p functions as a novel tumor suppressor in lung adenocarcinoma. (PMID: 30942957) Li X … Yu X (The FEBS journal 2019) 3
- Long non-coding RNA HOXA-AS2 promotes migration and invasion by acting as a ceRNA of miR-520c-3p in osteosarcoma cells. (PMID: 30081707) Wang Y … Han X (Cell cycle (Georgetown, Tex.) 2018) 3
- MicroRNA-520c-3p negatively regulates EMT by targeting IL-8 to suppress the invasion and migration of breast cancer. (PMID: 29048659) Tang CP … Zhang T (Oncology reports 2017) 3
ExternalLinks
Products for MIR520C Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR520C
- Origene Custom Protein Services for MIR520C
- Browse OriGene Inhibitory RNA Products For MIR520C
- OriGene qPCR primer pairs for MIR520C
- Browse CRISPR knockouts for MIR520C
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MIR520C
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for MIR520C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for MIR520C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MIR520C
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for MIR520C
Sources for MIR520C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB