microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520B Gene

Subcategory (RNA class) for MIR520B Gene

miRNA

Quality Score for this RNA gene is

16

Aliases for MIR520B Gene

  • MicroRNA 520b 2 3 5
  • Hsa-Mir-520b 3
  • MIMAT0037325 53
  • Hsa-MiR-520b 179
  • MIMAT0037327 53
  • MIMAT0002843 53
  • MI0003155 53
  • MIRN520B 3
  • MIR520B 2
  • RF00639 174

External Ids for MIR520B Gene

Previous HGNC Symbols for MIR520B Gene

  • MIRN520B

Previous GeneCards Identifiers for MIR520B Gene

  • GC19P058919
  • GC19P058996
  • GC19P054204
  • GC19P053703
  • GC19P053733
  • GC19P053981
  • GC19P054014
  • GC19P053767
  • GC19P053800
  • GC19P053831
  • GC19P053846
  • GC19P053863
  • GC19P053899
  • GC19P053928
  • GC19P053956

Summaries for MIR520B Gene

Entrez Gene Summary for MIR520B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520B Gene

MIR520B (MicroRNA 520b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR520B Gene

Additional gene information for MIR520B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520B Gene

Genomics for MIR520B Gene

GeneHancer (GH) Regulatory Elements for MIR520B Gene

Promoters and enhancers for MIR520B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR520B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR520B Gene

Genomic Locations for MIR520B Gene
chr19:53,701,214-53,701,300
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr19:54,204,481-54,204,541
(GRCh37/hg19)
Size:
61 bases
Orientation:
Plus strand

Genomic View for MIR520B Gene

Genes around MIR520B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR520B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520B Gene

Proteins for MIR520B Gene

Post-translational modifications for MIR520B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520B Gene

Domains & Families for MIR520B Gene

Gene Families for MIR520B Gene

genes like me logo Genes that share domains with MIR520B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520B Gene

Function for MIR520B Gene

Gene Ontology (GO) - Molecular Function for MIR520B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR520B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520B Gene

Localization for MIR520B Gene

Gene Ontology (GO) - Cellular Components for MIR520B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR520B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR520B Gene

Pathways & Interactions for MIR520B Gene

PathCards logo

SuperPathways for MIR520B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520B: view

Pathways by source for MIR520B Gene

1 KEGG pathway for MIR520B Gene

Gene Ontology (GO) - Biological Process for MIR520B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 20574151
GO:0045958 positive regulation of complement activation, alternative pathway IDA 20574151
GO:2000010 positive regulation of protein localization to cell surface IDA 20574151
genes like me logo Genes that share ontologies with MIR520B: view

No data available for SIGNOR curated interactions for MIR520B Gene

Drugs & Compounds for MIR520B Gene

No Compound Related Data Available

Transcripts for MIR520B Gene

mRNA/cDNA for MIR520B Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(5) RNACentral transcripts :
(4) miRBase transcripts :
(2) ENA transcripts :
(1) TarBase transcripts :
(1) Rfam transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520B Gene

No ASD Table

Relevant External Links for MIR520B Gene

GeneLoc Exon Structure for
MIR520B
ECgene alternative splicing isoforms for
MIR520B

Expression for MIR520B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR520B Gene:

MIR520B
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520B Gene

Orthologs for MIR520B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520b 33
  • 100 (a)
OneToOne
Species where no ortholog for MIR520B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR520B Gene

ENSEMBL:
Gene Tree for MIR520B (if available)
TreeFam:
Gene Tree for MIR520B (if available)

Paralogs for MIR520B Gene

No data available for Paralogs for MIR520B Gene

Variants for MIR520B Gene

Sequence variations from dbSNP and Humsavar for MIR520B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000787775 -- 53,701,307(+) A/G downstream_transcript_variant
rs1001586043 -- 53,700,531(+) C/T upstream_transcript_variant
rs1002210725 -- 53,700,556(+) G/C upstream_transcript_variant
rs1002381090 -- 53,699,786(+) T/C upstream_transcript_variant
rs1002589013 -- 53,701,554(+) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR520B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR520B Gene

Disorders for MIR520B Gene

Additional Disease Information for MIR520B

No disorders were found for MIR520B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR520B Gene

Publications for MIR520B Gene

  1. Capn4 expression is modulated by microRNA-520b and exerts an oncogenic role in prostate cancer cells by promoting Wnt/β-catenin signaling. (PMID: 30241050) Ren W … Fu X (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  2. MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1). (PMID: 28470146) Xiao J … Ren F (Oncology research 2018) 3 56
  3. MiR-520b restrains cell growth by targeting HDAC4 in lung cancer. (PMID: 30106218) Jin K … Zhang H (Thoracic cancer 2018) 3 56
  4. MiR-520b as a novel molecular target for suppressing stemness phenotype of head-neck cancer by inhibiting CD44. (PMID: 28515423) Lu YC … Chang JT (Scientific reports 2017) 3 56
  5. miR-520 promotes DNA-damage-induced trophoblast cell apoptosis by targeting PARP1 in recurrent spontaneous abortion (RSA). (PMID: 28042738) Dong X … Wang H (Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2017) 3 56

Products for MIR520B Gene

Sources for MIR520B Gene