microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR520A Gene

Subcategory (RNA class) for MIR520A Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR520A Gene

  • MicroRNA 520a 2 3 5
  • Hsa-MiR-520a-3p 163 173
  • Hsa-MiR-520a-5p 163 173
  • Hsa-Mir-520a 2 3
  • MIR520A 2 5
  • Hsa-Mir-430-P31 178
  • MIMAT0002833 50
  • MIMAT0002834 50
  • MI0003149 50
  • MIRN520A 3
  • RF00639 168

External Ids for MIR520A Gene

Previous HGNC Symbols for MIR520A Gene

  • MIRN520A

Previous GeneCards Identifiers for MIR520A Gene

  • GC19P058886
  • GC19P054195
  • GC19P054196
  • GC19P054202
  • GC19P054221
  • GC19P054270
  • GC19P054318
  • GC19P054338
  • GC19P054410
  • GC19P054486

Summaries for MIR520A Gene

Entrez Gene Summary for MIR520A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR520A Gene

MIR520A (MicroRNA 520a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR520A include Lymphoma, Hodgkin, Classic and Placental Insufficiency. Among its related pathways are MicroRNAs in cancer.

Rfam classification for MIR520A Gene

Additional gene information for MIR520A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR520A Gene

Genomics for MIR520A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR520A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR520A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR520A Gene

Genomic Locations for MIR520A Gene
chr19:53,690,880-53,690,966
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr19:54,194,135-54,194,219
(GRCh37/hg19)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR520A Gene

Genes around MIR520A on UCSC Golden Path with GeneCards custom track
MIR520A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR520A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR520A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR520A Gene

Proteins for MIR520A Gene

Post-translational modifications for MIR520A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR520A Gene

Domains & Families for MIR520A Gene

Gene Families for MIR520A Gene

genes like me logo Genes that share domains with MIR520A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR520A Gene

Function for MIR520A Gene

Phenotypes From GWAS Catalog for MIR520A Gene

Gene Ontology (GO) - Molecular Function for MIR520A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR520A: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR520A Gene

Localization for MIR520A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR520A gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR520A Gene

Pathways & Interactions for MIR520A Gene

PathCards logo

SuperPathways for MIR520A Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR520A: view

Pathways by source for MIR520A Gene

1 KEGG pathway for MIR520A Gene

Gene Ontology (GO) - Biological Process for MIR520A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 20190813
GO:0035195 gene silencing by miRNA IDA, IEA --
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IDA 20190813
genes like me logo Genes that share ontologies with MIR520A: view

No data available for Interacting Proteins and SIGNOR curated interactions for MIR520A Gene

Drugs & Compounds for MIR520A Gene

No Compound Related Data Available

Transcripts for MIR520A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR520A Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000534239_9606 miRNA 21 6

RefSeq: NR_030189,

LncBase: hsa-miR-520a-5p,

miRBase: MIMAT0002833,

MirGeneDB: Hsa-Mir-430-P31_5p,

TarBase: hsa-miR-520a-5p,

ENA: AY882292.1:1..21:ncRNA,

URS0000101689_9606 miRNA 22 5

RefSeq: NR_030189,

LncBase: hsa-miR-520a-3p,

miRBase: MIMAT0002834,

TarBase: hsa-miR-520a-3p,

ENA: AY785926.1:1..22:ncRNA,

URS000075D78D_9606 precursor_RNA 85 4

HGNC: 32099,

RefSeq: NR_030189,

Ensembl: ENST00000384862 (view in UCSC) ,

miRBase: MI0003149,

URS0000695C42_9606 precursor_RNA 87 1

Rfam: RF00639,

URS0000EFBD3D_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-430-P31,

MIR520A in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR520A Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR520A Gene

No ASD Table

Relevant External Links for MIR520A Gene

GeneLoc Exon Structure for
MIR520A

Expression for MIR520A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR520A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR520A

genes like me logo Genes that share expression patterns with MIR520A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR520A Gene

Orthologs for MIR520A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR520A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-520a 31
  • 99 (a)
OneToOne
Species where no ortholog for MIR520A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR520A Gene

ENSEMBL:
Gene Tree for MIR520A (if available)
TreeFam:
Gene Tree for MIR520A (if available)

Paralogs for MIR520A Gene

No data available for Paralogs for MIR520A Gene

Variants for MIR520A Gene

Additional dbSNP identifiers (rs#s) for MIR520A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR520A Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718834 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR520A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR520A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR520A Gene

Disorders for MIR520A Gene

MalaCards: The human disease database

(6) MalaCards diseases for MIR520A Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
lymphoma, hodgkin, classic
  • chl
placental insufficiency
  • uteroplacental vascular insufficiency
placenta disease
  • placenta disorder
bronchus cancer
  • malignant neoplasm of bronchus and lung
uterine anomalies
  • uterine disease
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR520A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR520A Gene

Publications for MIR520A Gene

  1. MicroRNA-520a-3p suppresses epithelial-mesenchymal transition, invasion, and migration of papillary thyroid carcinoma cells via the JAK1-mediated JAK/STAT signaling pathway. (PMID: 30206929) Bi CL … Fu YL (Journal of cellular physiology 2019) 3
  2. MicroRNA-520a suppresses HBV replication in HepG2.2.15 cells by inactivating AKT. (PMID: 30191752) Sun W … Chen J (The Journal of international medical research 2018) 3
  3. LINC01116 targets miR-520a-3p and affects IL6R to promote the proliferation and migration of osteosarcoma cells through the Jak-stat signaling pathway. (PMID: 30098545) Zhang B … Jiang J (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  4. MicroRNA-520a-3p inhibits cell growth and metastasis of non-small cell lung cancer through PI3K/AKT/mTOR signaling pathway. (PMID: 29762835) Lv X … Xu XY (European review for medical and pharmacological sciences 2018) 3
  5. A Novel Role for MiR-520a-3p in Regulating EGFR Expression in Colorectal Cancer. (PMID: 28738328) Zhang R … Chen X (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3

Products for MIR520A Gene

Sources for MIR520A Gene