microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR519E Gene

Data sources for MIR519E Gene:

RNA type for MIR519E Gene

miRNA

Aliases for MIR519E Gene

External Ids for MIR519E Gene

Previous HGNC Symbols for MIR519E Gene

  • MIRN519E

Previous GeneCards Identifiers for MIR519E Gene

  • GC19P058878
  • GC19P054183
  • GC19P053680
  • GC19P053689
  • GC19P053980
  • GC19P054013
  • GC19P054037
  • GC19P054098
  • GC19P053715
  • GC19P053749
  • GC19P053778
  • GC19P053828
  • GC19P053855
  • GC19P053893
  • GC19P053927
  • GC19P053955
  • GC19P054614
  • GC19P055565

Summaries for MIR519E Gene

Entrez Gene Summary for MIR519E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519E Gene

MIR519E (MicroRNA 519e) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR519E Gene

Additional gene information for MIR519E Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR519E Gene

Genomics for MIR519E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR519E Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053656 Enhancer 1.1 Ensembl ENCODE dbSUPER 13.1 -20.1 -20142 5.6 CHD4 REST HOMEZ FOXA2 SMAD4 SAP130 ETV4 RARA CTCF TEAD3 ENSG00000270347 LOC100288093 lnc-NLRP12-5 MIR519E MIR1283-1 MIR515-2 MIR519C MIR520A RN7SL317P DPRX
GH19J053840 Enhancer 0.9 ENCODE 11.1 +162.3 162282 2.5 ZNF654 JUND ZNF10 NFIC CEBPB CTCF REST ZNF217 ZNF513 ARNT MYADM-AS1 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19J053844 Enhancer 0.6 FANTOM5 ENCODE 11.1 +165.1 165097 0.2 CEBPB HLF ATF2 CEBPG MYADM-AS1 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19J053843 Enhancer 0.5 ENCODE 11.1 +164.0 164002 0.2 FOXA2 BHLHE40 NFIL3 CREB1 EMSY MYADM-AS1 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR515-2 MIR519C MIR515-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR519E on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR519E Gene

Latest Assembly
chr19:53,679,940-53,680,023
(GRCh38/hg38)
Size:
84 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,183,194-54,183,277
(GRCh37/hg19 by Entrez Gene)
Size:
84 bases
Orientation:
Plus strand

chr19:54,183,194-54,183,277
(GRCh37/hg19 by Ensembl)
Size:
84 bases
Orientation:
Plus strand

Genomic View for MIR519E Gene

Genes around MIR519E on UCSC Golden Path with GeneCards custom track
MIR519E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR519E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519E Gene

Proteins for MIR519E Gene

Post-translational modifications for MIR519E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519E Gene

Domains & Families for MIR519E Gene

Gene Families for MIR519E Gene

genes like me logo Genes that share domains with MIR519E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR519E Gene

Function for MIR519E Gene

Gene Ontology (GO) - Molecular Function for MIR519E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR519E: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519E Gene

Localization for MIR519E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR519E gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR519E Gene

Pathways & Interactions for MIR519E Gene

PathCards logo

SuperPathways for MIR519E Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR519E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA, IEA --
genes like me logo Genes that share ontologies with MIR519E: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR519E Gene

Drugs & Compounds for MIR519E Gene

No Compound Related Data Available

Transcripts for MIR519E Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR519E Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00006B3851_9606 pre_miRNA 84 4

RefSeq: NR_030185,

Ensembl: ENST00000385075 (view in UCSC) ,

miRBase: MI0003145,

Rfam: RF00639,

URS00004F4C18_9606 miRNA 22 3

RefSeq: NR_030185,

miRBase: MIMAT0002829,

TarBase: hsa-miR-519e-3p,

URS000075AC86_9606 miRNA 22 3

RefSeq: NR_030185,

miRBase: MIMAT0002828,

MirGeneDB: Hsa-Mir-430-P30_5p,

URS0000EFE99C_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-430-P30,

URS00001D18D1_9606 miRNA 23 1

ENA: AY785938.1:1..23:ncRNA,

MIR519E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR519E Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519E Gene

No ASD Table

Relevant External Links for MIR519E Gene

GeneLoc Exon Structure for
MIR519E

Expression for MIR519E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR519E Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR519E

genes like me logo Genes that share expression patterns with MIR519E: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR519E Gene

Orthologs for MIR519E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-519e 30
  • 95 (a)
OneToOne
Species where no ortholog for MIR519E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR519E Gene

ENSEMBL:
Gene Tree for MIR519E (if available)
TreeFam:
Gene Tree for MIR519E (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR519E

Paralogs for MIR519E Gene

No data available for Paralogs for MIR519E Gene

Variants for MIR519E Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR519E Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR519E Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR519E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR519E
Leiden Open Variation Database (LOVD)
MIR519E

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR519E Gene

Disorders for MIR519E Gene

Additional Disease Information for MIR519E

No disorders were found for MIR519E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519E Gene

Publications for MIR519E Gene

  1. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. (PMID: 20190813) Wu S … He X (Oncogene 2010) 3
  2. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  4. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I … Bentwich Z (Nature genetics 2005) 3

Products for MIR519E Gene

Sources for MIR519E Gene