microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR519D Gene

Data sources for MIR519D Gene:

RNA type for MIR519D Gene

miRNA

Aliases for MIR519D Gene

External Ids for MIR519D Gene

Previous HGNC Symbols for MIR519D Gene

  • MIRN519D

Previous GeneCards Identifiers for MIR519D Gene

  • GC19P058941
  • GC19P059005
  • GC19P054217
  • GC19P054220
  • GC19P054269
  • GC19P054317
  • GC19P054336
  • GC19P054409
  • GC19P054484

Summaries for MIR519D Gene

Entrez Gene Summary for MIR519D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519D Gene

MIR519D (MicroRNA 519d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR519D include Primary Biliary Cholangitis.

Rfam classification for MIR519D Gene

Additional gene information for MIR519D Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR519D Gene

Genomics for MIR519D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR519D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR519D on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR519D Gene

Latest Assembly
chr19:53,713,347-53,713,434
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,216,601-54,216,688
(GRCh37/hg19 by Entrez Gene)
Size:
88 bases
Orientation:
Plus strand

chr19:54,216,601-54,216,688
(GRCh37/hg19 by Ensembl)
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR519D Gene

Genes around MIR519D on UCSC Golden Path with GeneCards custom track
MIR519D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR519D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519D Gene

Proteins for MIR519D Gene

Post-translational modifications for MIR519D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519D Gene

Domains & Families for MIR519D Gene

Gene Families for MIR519D Gene

genes like me logo Genes that share domains with MIR519D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR519D Gene

Function for MIR519D Gene

Gene Ontology (GO) - Molecular Function for MIR519D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR519D: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519D Gene

Localization for MIR519D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR519D gene
Compartment Confidence
extracellular 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endosome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR519D Gene

Pathways & Interactions for MIR519D Gene

PathCards logo

SuperPathways for MIR519D Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR519D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 20190813
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP 20190813
genes like me logo Genes that share ontologies with MIR519D: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR519D Gene

Drugs & Compounds for MIR519D Gene

No Compound Related Data Available

Transcripts for MIR519D Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR519D Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00006656A0_9606 pre_miRNA 88 5

RefSeq: NR_030202,

Ensembl: ENST00000385246 (view in UCSC) ,

miRBase: MI0003162,

Rfam: RF00639,

ENA: LM609482.1:1..88:precursor_RNA,

URS0000298BA3_9606 miRNA 22 4

RefSeq: NR_030202,

miRBase: MIMAT0002853,

TarBase: hsa-miR-519d-3p,

ENA: LM379787.1:1..22:ncRNA, LM609482.1:54..75:ncRNA,

URS000075AFE4_9606 miRNA 25 3

RefSeq: NR_030202,

miRBase: MIMAT0026610,

ENA: LM609482.1:15..39:ncRNA,

URS0000301C0E_9606 miRNA 24 2

MirGeneDB: Hsa-Mir-430-P29_5p,

ENA: AB372811.1:1..24:ncRNA,

URS00003122BC_9606 miRNA 23 2

MirGeneDB: Hsa-Mir-430-P29_3p,

ENA: AY785939.1:1..23:ncRNA,

MIR519D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR519D Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519D Gene

No ASD Table

Relevant External Links for MIR519D Gene

GeneLoc Exon Structure for
MIR519D

Expression for MIR519D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR519D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR519D

genes like me logo Genes that share expression patterns with MIR519D: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR519D Gene

Orthologs for MIR519D Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-519d 30
  • 99 (a)
OneToOne
Species where no ortholog for MIR519D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR519D Gene

ENSEMBL:
Gene Tree for MIR519D (if available)
TreeFam:
Gene Tree for MIR519D (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR519D

Paralogs for MIR519D Gene

No data available for Paralogs for MIR519D Gene

Variants for MIR519D Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR519D Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR519D Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR519D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR519D
Leiden Open Variation Database (LOVD)
MIR519D

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR519D Gene

Disorders for MIR519D Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR519D Gene - From: MID

Disorder Aliases PubMed IDs
primary biliary cholangitis
  • biliary liver cirrhosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR519D

genes like me logo Genes that share disorders with MIR519D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR519D Gene

Publications for MIR519D Gene

  1. Down-regulation of lncRNA BLACAT1 inhibits ovarian cancer progression by suppressing the Wnt/β-catenin signaling pathway via regulating miR-519d-3p. (PMID: 32095930) Yang H … Shi TM (Molecular and cellular biochemistry 2020) 3
  2. MicroRNA-519d-3p inhibits cell proliferation and cell cycle G1/S transition in glioma by targeting CCND1. (PMID: 31661371) Ma L … Li J (Bioscience, biotechnology, and biochemistry 2020) 3
  3. MiR-519d targets HER3 and can be used as a potential serum biomarker for non-small cell lung cancer. (PMID: 32170048) Wang A … Xu Z (Aging 2020) 3
  4. Circular noncoding RNA circMBOAT2 is a novel tumor marker and regulates proliferation/migration by sponging miR-519d-3p in colorectal cancer. (PMID: 32796815) Tang X … Qu H (Cell death & disease 2020) 3
  5. Long noncoding RNA PVT1 promotes laryngeal squamous cell carcinoma development by acting as a molecular sponge to regulate miR-519d-3p. (PMID: 30304557) Zheng X … Xu M (Journal of cellular biochemistry 2019) 3

Products for MIR519D Gene

Sources for MIR519D Gene