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Aliases for MIR519C Gene

Subcategory (RNA class) for MIR519C Gene


Quality Score for this RNA gene is


Aliases for MIR519C Gene

  • MicroRNA 519c 2 3 5
  • Hsa-Mir-519c 3
  • Mir-519c 3
  • MIRN519C 3

External Ids for MIR519C Gene

ORGUL Members for MIR519C Gene

Previous HGNC Symbols for MIR519C Gene

  • MIRN519C

Previous GeneCards Identifiers for MIR519C Gene

  • GC19P058884
  • GC19P054190
  • GC19P054193
  • GC19P054207
  • GC19P054256
  • GC19P054305
  • GC19P054312
  • GC19P054334
  • GC19P054405
  • GC19P054482

Summaries for MIR519C Gene

Entrez Gene Summary for MIR519C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519C Gene

MIR519C (MicroRNA 519c) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR519C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR519C Gene

Genomics for MIR519C Gene

GeneHancer (GH) Regulatory Elements for MIR519C Gene

Promoters and enhancers for MIR519C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I053840 Enhancer 1.1 Ensembl ENCODE 11.1 +155.7 155660 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 FOS ATF7 SP3 REST LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19I053659 Enhancer 0.9 ENCODE dbSUPER 13.1 -25.2 -25194 2.7 ELF3 SOX13 FOXA2 SAP130 NR2F6 CREM GATAD2A SOX5 SP5 PPARG MIR515-2 MIR1283-1 MIR519C MIR520A MIR519B MIR526B MIR518F MIR520B MIR525 MIR518B
GH19I053844 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.1 +158.6 158625 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19I053843 Enhancer 0.4 ENCODE 11.1 +157.5 157473 0.2 NFIL3 CREB1 EMSY LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR515-2 MIR519C MIR515-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR519C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR519C Gene

Genomic Locations for MIR519C Gene
87 bases
Plus strand

Genomic View for MIR519C Gene

Genes around MIR519C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR519C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519C Gene

Proteins for MIR519C Gene

Post-translational modifications for MIR519C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519C Gene

Domains & Families for MIR519C Gene

Gene Families for MIR519C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR519C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR519C Gene

Function for MIR519C Gene

Gene Ontology (GO) - Molecular Function for MIR519C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MIR519C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519C Gene

Localization for MIR519C Gene

Gene Ontology (GO) - Cellular Components for MIR519C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR519C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR519C Gene

Pathways & Interactions for MIR519C Gene

SuperPathways for MIR519C Gene

No Data Available

Interacting Proteins for MIR519C Gene

Gene Ontology (GO) - Biological Process for MIR519C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MIR519C: view

No data available for Pathways by source and SIGNOR curated interactions for MIR519C Gene

Drugs & Compounds for MIR519C Gene

No Compound Related Data Available

Transcripts for MIR519C Gene

mRNA/cDNA for MIR519C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519C Gene

No ASD Table

Relevant External Links for MIR519C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR519C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR519C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR519C Gene:

genes like me logo Genes that share expression patterns with MIR519C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR519C Gene

Orthologs for MIR519C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-519c 34
  • 100 (a)
Species where no ortholog for MIR519C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR519C Gene

Gene Tree for MIR519C (if available)
Gene Tree for MIR519C (if available)

Paralogs for MIR519C Gene

No data available for Paralogs for MIR519C Gene

Variants for MIR519C Gene

Sequence variations from dbSNP and Humsavar for MIR519C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1003256659 -- 53,684,783(+) G/A upstream_transcript_variant
rs1003801952 -- 53,684,997(+) G/A upstream_transcript_variant
rs1004013404 -- 53,685,950(+) A/G upstream_transcript_variant
rs1004129351 -- 53,685,678(+) C/A upstream_transcript_variant
rs1004534276 -- 53,685,449(+) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR519C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR519C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR519C Gene

Disorders for MIR519C Gene

Additional Disease Information for MIR519C

No disorders were found for MIR519C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519C Gene

Publications for MIR519C Gene

  1. Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer. (PMID: 26386386) To KK … Ng SS (Experimental cell research 2015) 3 58
  2. Regulation and expression of the ATP-binding cassette transporter ABCG2 in human embryonic stem cells. (PMID: 22887864) Padmanabhan R … Gottesman MM (Stem cells (Dayton, Ohio) 2012) 3 58
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 58
  4. Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. (PMID: 21219875) Li X … Yu AM (Biochemical pharmacology 2011) 3 58
  5. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. (PMID: 20233879) Cha ST … Kuo ML (Cancer research 2010) 3 58

Products for MIR519C Gene

Sources for MIR519C Gene

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