microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR519B Gene

RNA type for MIR519B Gene

miRNA

Aliases for MIR519B Gene

External Ids for MIR519B Gene

Previous HGNC Symbols for MIR519B Gene

  • MIRN519B

Previous GeneCards Identifiers for MIR519B Gene

  • GC19P058899
  • GC19P054198

Summaries for MIR519B Gene

Entrez Gene Summary for MIR519B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519B Gene

MIR519B (MicroRNA 519b) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR519B Gene

Additional gene information for MIR519B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR519B Gene

Genomics for MIR519B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR519B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR519B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR519B Gene

Latest Assembly
chr19:53,695,210-53,695,296
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,198,467-54,198,547
(GRCh37/hg19 by Entrez Gene)
Size:
81 bases
Orientation:
Plus strand

chr19:54,198,467-54,198,547
(GRCh37/hg19 by Ensembl)
Size:
81 bases
Orientation:
Plus strand

Genomic View for MIR519B Gene

Genes around MIR519B on UCSC Golden Path with GeneCards custom track
MIR519B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR519B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519B Gene

Proteins for MIR519B Gene

Post-translational modifications for MIR519B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519B Gene

Domains & Families for MIR519B Gene

Gene Families for MIR519B Gene

genes like me logo Genes that share domains with MIR519B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR519B Gene

Function for MIR519B Gene

Gene Ontology (GO) - Molecular Function for MIR519B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR519B: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519B Gene

Localization for MIR519B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR519B gene
Compartment Confidence
extracellular 1
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR519B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR519B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR519B Gene

Pathways & Interactions for MIR519B Gene

PathCards logo

SuperPathways for MIR519B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR519B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0035195 gene silencing by miRNA IDA,IEA --
genes like me logo Genes that share ontologies with MIR519B: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR519B Gene

Drugs & Compounds for MIR519B Gene

No Compound Related Data Available

Transcripts for MIR519B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR519B Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00003883FE_9606 miRNA 22 6

RefSeq: NR_030191,

LncBase: hsa-miR-519b-3p,

miRBase: MIMAT0002837,

MirGeneDB: Hsa-Mir-430-P27_3p,

TarBase: hsa-miR-519b-3p,

ENA: LM609477.1:51..72:ncRNA,

URS00005ECFE5_9606 miRNA 22 6

RefSeq: NR_030188, NR_030191, NR_030193, NR_030209, NR_030217,

LncBase: hsa-miR-522-5p,

miRBase: MIMAT0005454,

MirGeneDB: Hsa-Mir-430-P23_5p, Hsa-Mir-430-P27_5p, Hsa-Mir-430-P28_5p, Hsa-Mir-430-P41_5p, Hsa-Mir-430-P42_5p,

TarBase: hsa-miR-519a-5p, hsa-miR-522-5p,

ENA: View 12 records in RNAcentral

URS000075EA92_9606 pre_miRNA 81 4

RefSeq: NR_030191,

Ensembl: ENST00000385090 (view in UCSC) ,

miRBase: MI0003151,

ENA: LM609477.1:1..81:precursor_RNA,

URS0000633613_9606 pre_miRNA 87 1

Rfam: RF00639,

URS0001BC0F4A_9606 pre_miRNA 87 1

Rfam: RF00639,

MIR519B in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR519B Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519B Gene

No ASD Table

Relevant External Links for MIR519B Gene

GeneLoc Exon Structure for
MIR519B

Expression for MIR519B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR519B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR519B

genes like me logo Genes that share expression patterns with MIR519B: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR519B Gene

Orthologs for MIR519B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR519B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-519b 30
  • 100 (a)
OneToOne
Species where no ortholog for MIR519B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR519B Gene

ENSEMBL:
Gene Tree for MIR519B (if available)
TreeFam:
Gene Tree for MIR519B (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR519B

Paralogs for MIR519B Gene

No data available for Paralogs for MIR519B Gene

Variants for MIR519B Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR519B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR519B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718834 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR519B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR519B
Leiden Open Variation Database (LOVD)
MIR519B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR519B Gene

Disorders for MIR519B Gene

Additional Disease Information for MIR519B

No disorders were found for MIR519B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519B Gene

Publications for MIR519B Gene

  1. LINC01419 promotes cell proliferation and metastasis in lung adenocarcinoma via sponging miR-519b-3p to up-regulate RCCD1. (PMID: 31582214) Cheng Z … Yuan M (Biochemical and biophysical research communications 2019) 3
  2. Upregulation of miR-519 enhances radiosensitivity of esophageal squamous cell carcinoma trough targeting PI3K/AKT/mTOR signaling pathway. (PMID: 31529206) Zhang Y … Li C (Cancer chemotherapy and pharmacology 2019) 3
  3. Genome-wide identification of microRNAs regulating the human prion protein. (PMID: 30451334) Pease D … Aguzzi A (Brain pathology (Zurich, Switzerland) 2019) 3
  4. miR-519b-3p promotes responsiveness to preoperative chemoradiotherapy in rectal cancer patients by targeting ARID4B. (PMID: 29477868) Luo J … Chen M (Gene 2018) 3
  5. Transforming growth factor β1 enhances heme oxygenase 1 expression in human synovial fibroblasts by inhibiting microRNA 519b synthesis. (PMID: 28423042) Kuo SJ … Tang CH (PloS one 2017) 3

Products for MIR519B Gene

Sources for MIR519B Gene