microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR519A2 Gene

Data sources for MIR519A2 Gene:

RNA type for MIR519A2 Gene

miRNA

Aliases for MIR519A2 Gene

External Ids for MIR519A2 Gene

Previous HGNC Symbols for MIR519A2 Gene

  • MIRN519A-2
  • MIRN519A2

Previous GeneCards Identifiers for MIR519A2 Gene

  • GC19P058990
  • GC19P059029
  • GC19P054266
  • GC19P054268
  • GC19P054316
  • GC19P054341
  • GC19P054426
  • GC19P054506
  • GC19P053793
  • GC19P053826

Summaries for MIR519A2 Gene

Entrez Gene Summary for MIR519A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR519A2 Gene

MIR519A2 (MicroRNA 519a-2) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR519A2 Gene

Additional gene information for MIR519A2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR519A2 Gene

Genomics for MIR519A2 Gene

Genomic Locations for MIR519A2 Gene

Latest Assembly
chr19:53,762,344-53,762,430
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,265,598-54,265,684
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR519A2 Gene

Genes around MIR519A2 on UCSC Golden Path with GeneCards custom track
MIR519A2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR519A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR519A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR519A2 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR519A2 Gene

Proteins for MIR519A2 Gene

Post-translational modifications for MIR519A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR519A2 Gene

Domains & Families for MIR519A2 Gene

Gene Families for MIR519A2 Gene

genes like me logo Genes that share domains with MIR519A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR519A2 Gene

Function for MIR519A2 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR519A2 Gene

Localization for MIR519A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR519A2 Gene

Pathways & Interactions for MIR519A2 Gene

PathCards logo

SuperPathways for MIR519A2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR519A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR519A2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR519A2 Gene

Drugs & Compounds for MIR519A2 Gene

No Compound Related Data Available

Transcripts for MIR519A2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR519A2 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000135E29_9606 miRNA 22 6

RefSeq: NR_030218, NR_030222,

LncBase: hsa-miR-519a-3p,

miRBase: MIMAT0002869,

MirGeneDB: Hsa-Mir-430-P25_3p, Hsa-Mir-430-P26_3p,

TarBase: hsa-miR-519a-3p,

ENA: AY785924.1:1..22:ncRNA, LM379793.1:1..22:ncRNA, LM609493.1:53..74:ncRNA, LM609496.1:54..75:ncRNA,

URS0000007095_9606 pre_miRNA 87 5

RefSeq: NR_030222,

Ensembl: ENST00000384990 (view in UCSC) ,

miRBase: MI0003182,

Rfam: RF00639,

ENA: HI454490.1:1..87:misc_RNA, LM609496.1:1..87:precursor_RNA,

URS0000D5654E_9606 miRNA 21 2

RefSeq: NR_030195, NR_030222,

miRBase: MIMAT0037327,

URS00004B8193_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-430-P26_5p, Hsa-Mir-430-P32_5p,

ENA: AB372805.1:1..22:ncRNA,

URS0000EFC9DE_9606 precursor_RNA 62 1

MirGeneDB: Hsa-Mir-430-P26,

MIR519A2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR519A2 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR519A2 Gene

No ASD Table

Relevant External Links for MIR519A2 Gene

GeneLoc Exon Structure for
MIR519A2

Expression for MIR519A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR519A2 Gene

mRNA differential expression in normal tissues according to GTEx for MIR519A2 Gene

This gene is overexpressed in Testis (x40.1) and Breast - Mammary Tissue (x4.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR519A2

genes like me logo Genes that share expression patterns with MIR519A2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR519A2 Gene

Orthologs for MIR519A2 Gene

Evolution for MIR519A2 Gene

ENSEMBL:
Gene Tree for MIR519A2 (if available)
TreeFam:
Gene Tree for MIR519A2 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR519A2

No data available for Orthologs for MIR519A2 Gene

Paralogs for MIR519A2 Gene

No data available for Paralogs for MIR519A2 Gene

Variants for MIR519A2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR519A2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR519A2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
nsv1058969 CNV gain 25217958
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR519A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR519A2
Leiden Open Variation Database (LOVD)
MIR519A2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR519A2 Gene

Disorders for MIR519A2 Gene

Additional Disease Information for MIR519A2

No disorders were found for MIR519A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR519A2 Gene

Publications for MIR519A2 Gene

  1. Upregulation of miR-519 enhances radiosensitivity of esophageal squamous cell carcinoma trough targeting PI3K/AKT/mTOR signaling pathway. (PMID: 31529206) Zhang Y … Li C (Cancer chemotherapy and pharmacology 2019) 3
  2. Change in OncomicroRNA Expression in the Placenta during Preeclampsia. (PMID: 30353329) Nizyaeva NV … Shchegolev AI (Bulletin of experimental biology and medicine 2018) 3
  3. Selective microRNA-Offset RNA expression in human embryonic stem cells. (PMID: 25822230) Asikainen S … Hovatta O (PloS one 2015) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. Deregulation of miR-519a, 153, and 485-5p and its clinicopathological relevance in ovarian epithelial tumours. (PMID: 21083603) Kim TH … An HJ (Histopathology 2010) 3

Products for MIR519A2 Gene

Sources for MIR519A2 Gene