microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5196 Gene

Subcategory (RNA class) for MIR5196 Gene

miRNA

Number of RNA Genes sources:

4 / 17

Aliases for MIR5196 Gene

  • MicroRNA 5196 2 3 5
  • Hsa-MiR-5196-3p 163 173
  • Hsa-Mir-5196 2 3
  • MIR5196 2 5
  • MIMAT0021129 50
  • MIMAT0021128 50
  • MI0018175 50
  • Mir-5196 3

External Ids for MIR5196 Gene

Previous GeneCards Identifiers for MIR5196 Gene

  • GC19U901559
  • GC19P035840
  • GC19P035848
  • GC19P035959
  • GC19P035502
  • GC19P035511
  • GC19P037010
  • GC19P037178
  • GC19P037274
  • GC19P037708
  • GC19P035520
  • GC19P035323
  • GC19P036109
  • GC19P036225
  • GC19P036401
  • GC19P036561
  • GC19P036730
  • GC19P036872

Summaries for MIR5196 Gene

Entrez Gene Summary for MIR5196 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5196 Gene

MIR5196 (MicroRNA 5196) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Antigen activates B Cell Receptor (BCR) leading to generation of second messengers and B cell receptor signaling pathway (KEGG).

Additional gene information for MIR5196 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5196 Gene

Genomics for MIR5196 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5196 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J035345 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 0.7 +2.1 2139 4.1 SP1 POLR2A BACH1 STAT3 ZNF143 RELA ZIC2 ZSCAN4 SMAD5 TCF12 FFAR1 FFAR2 FFAR3 CD22 U2AF1L4 GRAMD1A USF2 FXYD5 IGFLR1 MIR5196
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5196 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5196 Gene

Genomic Locations for MIR5196 Gene
chr19:35,345,513-35,345,627
(GRCh38/hg38)
Size:
115 bases
Orientation:
Plus strand
chr19:35,836,416-35,836,530
(GRCh37/hg19)
Size:
115 bases
Orientation:
Plus strand

Genomic View for MIR5196 Gene

Genes around MIR5196 on UCSC Golden Path with GeneCards custom track
MIR5196 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR5196 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5196 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5196 Gene

Proteins for MIR5196 Gene

Post-translational modifications for MIR5196 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5196 Gene

Domains & Families for MIR5196 Gene

Gene Families for MIR5196 Gene

HGNC:
genes like me logo Genes that share domains with MIR5196: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5196 Gene

Function for MIR5196 Gene

Phenotypes From GWAS Catalog for MIR5196 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5196 Gene

Localization for MIR5196 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5196 Gene

Pathways & Interactions for MIR5196 Gene

genes like me logo Genes that share pathways with MIR5196: view

Gene Ontology (GO) - Biological Process for MIR5196 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR5196 Gene

Drugs & Compounds for MIR5196 Gene

No Compound Related Data Available

Transcripts for MIR5196 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5196 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075E0F8_9606 precursor_RNA 115 5

HGNC: 43542,

RefSeq: NR_049828,

Ensembl: ENST00000578146 (view in UCSC) ,

miRBase: MI0018175,

ENA: LM611543.1:1..115:precursor_RNA,

URS000075E072_9606 miRNA 21 5

RefSeq: NR_049828,

LncBase: hsa-miR-5196-3p,

miRBase: MIMAT0021129,

TarBase: hsa-miR-5196-3p,

ENA: LM382913.1:1..21:ncRNA, LM611543.1:69..89:ncRNA,

URS0000214763_9606 miRNA 22 3

RefSeq: NR_049828,

miRBase: MIMAT0021128,

ENA: LM382912.1:1..22:ncRNA, LM611543.1:29..50:ncRNA,

MIR5196 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR5196 Gene

1 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5196 Gene

No ASD Table

Relevant External Links for MIR5196 Gene

GeneLoc Exon Structure for
MIR5196

Expression for MIR5196 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5196 Gene

mRNA differential expression in normal tissues according to GTEx for MIR5196 Gene

This gene is overexpressed in Spleen (x9.4) and Ovary (x6.7).
genes like me logo Genes that share expression patterns with MIR5196: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5196 Gene

Orthologs for MIR5196 Gene

Evolution for MIR5196 Gene

ENSEMBL:
Gene Tree for MIR5196 (if available)
TreeFam:
Gene Tree for MIR5196 (if available)

No data available for Orthologs for MIR5196 Gene

Paralogs for MIR5196 Gene

No data available for Paralogs for MIR5196 Gene

Variants for MIR5196 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIR5196 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
723866 Likely Benign: not provided 35,345,594(+) C/T NON_CODING_TRANSCRIPT_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for MIR5196 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR5196 Gene

Variant ID Type Subtype PubMed ID
esv2758758 CNV loss 17122850
nsv1067129 CNV loss 25217958
nsv510765 CNV deletion 20534489
nsv833810 CNV gain 17160897

Additional Variant Information for MIR5196 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5196

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR5196 Gene

Disorders for MIR5196 Gene

Additional Disease Information for MIR5196

No disorders were found for MIR5196 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5196 Gene

Publications for MIR5196 Gene

  1. Changes in MiRNA-5196 Expression as a Potential Biomarker of Anti-TNF-α Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis Patients. (PMID: 29744553) Ciechomska M … Maslinski W (Archivum immunologiae et therapiae experimentalis 2018) 3
  2. The role of microRNA-5196 in the pathogenesis of systemic sclerosis. (PMID: 28639412) Ciechomska M … Bogunia-Kubik K (European journal of clinical investigation 2017) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  4. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D … den Boer ML (Leukemia 2011) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR5196 Gene

Sources for MIR5196 Gene