microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5193 Gene

Data sources for MIR5193 Gene:

RNA type for MIR5193 Gene

miRNA

Aliases for MIR5193 Gene

External Ids for MIR5193 Gene

Previous GeneCards Identifiers for MIR5193 Gene

  • GC03U901841
  • GC03M049847
  • GC03M049849

Summaries for MIR5193 Gene

Entrez Gene Summary for MIR5193 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5193 Gene

MIR5193 (MicroRNA 5193) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Class I MHC mediated antigen processing and presentation and DNA Double-Strand Break Repair.

Additional gene information for MIR5193 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5193 Gene

Genomics for MIR5193 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5193 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J049802 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +0.6 551 7.4 BCLAF1 SP1 ZNF207 ZNF654 MYC ZNF600 NCOR1 IKZF1 ZNF592 POLR2A INKA1 lnc-CDHR4-3 MIR5193 CDHR4 AMT WDR6 lnc-CDHR4-1 lnc-CDHR4-4 UBA7 RF00017-3607
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5193 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5193 Gene

Latest Assembly
chr3:49,806,137-49,806,245
(GRCh38/hg38)
Size:
109 bases
Orientation:
Minus strand

Previous Assembly
chr3:49,843,570-49,843,678
(GRCh37/hg19 by Entrez Gene)
Size:
109 bases
Orientation:
Minus strand

Genomic View for MIR5193 Gene

Genes around MIR5193 on UCSC Golden Path with GeneCards custom track
MIR5193 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR5193 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5193 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5193 Gene

Proteins for MIR5193 Gene

Post-translational modifications for MIR5193 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5193 Gene

Domains & Families for MIR5193 Gene

Gene Families for MIR5193 Gene

HGNC:
genes like me logo Genes that share domains with MIR5193: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5193 Gene

Function for MIR5193 Gene

Phenotypes From GWAS Catalog for MIR5193 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5193 Gene

Localization for MIR5193 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5193 Gene

Pathways & Interactions for MIR5193 Gene

genes like me logo Genes that share pathways with MIR5193: view

Gene Ontology (GO) - Biological Process for MIR5193 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MIR5193 Gene

Drugs & Compounds for MIR5193 Gene

No Compound Related Data Available

Transcripts for MIR5193 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5193 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075E648_9606 precursor_RNA 109 4

RefSeq: NR_049825,

Ensembl: ENST00000584510 (view in UCSC) ,

miRBase: MI0018172,

ENA: LM611541.1:1..109:precursor_RNA,

URS0000224AEA_9606 miRNA 22 4

RefSeq: NR_049825,

miRBase: MIMAT0021124,

TarBase: hsa-miR-5193,

ENA: LM382910.1:1..22:ncRNA, LM611541.1:60..81:ncRNA,

MIR5193 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR5193 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5193 Gene

No ASD Table

Relevant External Links for MIR5193 Gene

GeneLoc Exon Structure for
MIR5193

Expression for MIR5193 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5193 Gene

genes like me logo Genes that share expression patterns with MIR5193: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5193 Gene

Orthologs for MIR5193 Gene

Evolution for MIR5193 Gene

ENSEMBL:
Gene Tree for MIR5193 (if available)
TreeFam:
Gene Tree for MIR5193 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR5193

No data available for Orthologs for MIR5193 Gene

Paralogs for MIR5193 Gene

No data available for Paralogs for MIR5193 Gene

Variants for MIR5193 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR5193 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR5193 Gene

Variant ID Type Subtype PubMed ID
nsv834688 CNV loss 17160897

Additional Variant Information for MIR5193 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5193
Leiden Open Variation Database (LOVD)
MIR5193

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR5193 Gene

Disorders for MIR5193 Gene

Additional Disease Information for MIR5193

No disorders were found for MIR5193 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5193 Gene

Publications for MIR5193 Gene

  1. Expression of Tripartite Motif-Containing Proteactiin 11 (TRIM11) is Associated with the Progression of Human Prostate Cancer and is Downregulated by MicroRNA-5193. (PMID: 30608062) Pan Y … Lv J (Medical science monitor : international medical journal of experimental and clinical research 2019) 3
  2. Human miR-5193 Triggers Gene Silencing in Multiple Genotypes of Hepatitis B Virus. (PMID: 26456535) Khlaiphuengsin A … Payungporn S (MicroRNA (Shariqah, United Arab Emirates) 2015) 3
  3. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D … den Boer ML (Leukemia 2011) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR5193 Gene

Sources for MIR5193 Gene