microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR518E Gene

RNA type for MIR518E Gene

miRNA

Aliases for MIR518E Gene

External Ids for MIR518E Gene

Previous HGNC Symbols for MIR518E Gene

  • MIRN518E

Previous GeneCards Identifiers for MIR518E Gene

  • GC19P058966
  • GC19P059012
  • GC19P054233

Summaries for MIR518E Gene

Entrez Gene Summary for MIR518E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518E Gene

MIR518E (MicroRNA 518e) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR518E include Female Reproductive System Disease and Cervix Uteri Carcinoma In Situ.

Rfam classification for MIR518E Gene

Additional gene information for MIR518E Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR518E Gene

Genomics for MIR518E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR518E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR518E on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR518E Gene

Latest Assembly
chr19:53,729,838-53,729,925
(GRCh38/hg38)
Size:
88 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,233,092-54,233,179
(GRCh37/hg19 by Entrez Gene)
Size:
88 bases
Orientation:
Plus strand

chr19:54,233,092-54,233,179
(GRCh37/hg19 by Ensembl)
Size:
88 bases
Orientation:
Plus strand

Genomic View for MIR518E Gene

Genes around MIR518E on UCSC Golden Path with GeneCards custom track
MIR518E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR518E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518E Gene

Proteins for MIR518E Gene

Post-translational modifications for MIR518E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518E Gene

Domains & Families for MIR518E Gene

Gene Families for MIR518E Gene

genes like me logo Genes that share domains with MIR518E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR518E Gene

Function for MIR518E Gene

Gene Ontology (GO) - Molecular Function for MIR518E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MIR518E: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518E Gene

Localization for MIR518E Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR518E gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR518E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR518E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR518E Gene

Pathways & Interactions for MIR518E Gene

PathCards logo

SuperPathways for MIR518E Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR518E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR518E: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR518E Gene

Drugs & Compounds for MIR518E Gene

No Compound Related Data Available

Transcripts for MIR518E Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR518E Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00005ECFE5_9606 miRNA 22 6

RefSeq: NR_030188, NR_030191, NR_030193, NR_030209, NR_030217,

LncBase: hsa-miR-522-5p,

miRBase: MIMAT0005450,

MirGeneDB: Hsa-Mir-430-P23_5p, Hsa-Mir-430-P27_5p, Hsa-Mir-430-P28_5p, Hsa-Mir-430-P41_5p, Hsa-Mir-430-P42_5p,

TarBase: hsa-miR-519a-5p, hsa-miR-522-5p,

ENA: View 12 records in RNAcentral

URS0000651BF7_9606 pre_miRNA 88 5

RefSeq: NR_030209,

Ensembl: ENST00000385252 (view in UCSC) ,

miRBase: MI0003169,

Rfam: RF00639,

ENA: LM609487.1:1..88:precursor_RNA,

URS000075E57D_9606 miRNA 21 5

RefSeq: NR_030209,

LncBase: hsa-miR-518e-3p,

miRBase: MIMAT0002861,

TarBase: hsa-miR-518e-3p,

ENA: LM609487.1:54..74:ncRNA,

URS0000EFEE65_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-430-P23,

URS000008FFB9_9606 miRNA 24 1

ENA: AY882326.1:1..24:ncRNA,

MIR518E in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR518E Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518E Gene

No ASD Table

Relevant External Links for MIR518E Gene

GeneLoc Exon Structure for
MIR518E

Expression for MIR518E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR518E Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR518E

genes like me logo Genes that share expression patterns with MIR518E: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR518E Gene

Orthologs for MIR518E Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR518E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-518e 30
  • 100 (a)
OneToOne
Species where no ortholog for MIR518E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR518E Gene

ENSEMBL:
Gene Tree for MIR518E (if available)
TreeFam:
Gene Tree for MIR518E (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR518E

Paralogs for MIR518E Gene

No data available for Paralogs for MIR518E Gene

Variants for MIR518E Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR518E Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR518E Gene

Variant ID Type Subtype PubMed ID
esv2448351 CNV deletion 19546169
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR518E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR518E
Leiden Open Variation Database (LOVD)
MIR518E

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR518E Gene

Disorders for MIR518E Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR518E Gene - From: COP

Disorder Aliases PubMed IDs
female reproductive system disease
  • genital diseases, female
cervix uteri carcinoma in situ
  • carcinoma in situ of cervix
uterus carcinoma in situ
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR518E

genes like me logo Genes that share disorders with MIR518E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR518E Gene

Publications for MIR518E Gene

  1. microRNA profiling: increased expression of miR-147a and miR-518e in progressive supranuclear palsy (PSP). (PMID: 27052995) Tatura R … Müller U (Neurogenetics 2016) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  5. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I … Bentwich Z (Nature genetics 2005) 3

Products for MIR518E Gene

Sources for MIR518E Gene