microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR518D Gene

RNA type for MIR518D Gene

miRNA

Aliases for MIR518D Gene

External Ids for MIR518D Gene

Previous HGNC Symbols for MIR518D Gene

  • MIRN518D

Previous GeneCards Identifiers for MIR518D Gene

  • GC19P058971
  • GC19P059015
  • GC19P054239
  • GC19P054241
  • GC19P054274
  • GC19P054324
  • GC19P054344
  • GC19P054415
  • GC19P054497

Summaries for MIR518D Gene

Entrez Gene Summary for MIR518D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518D Gene

MIR518D (MicroRNA 518d) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR518D include Reproductive System Disease and Female Reproductive System Disease.

Rfam classification for MIR518D Gene

Additional gene information for MIR518D Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR518D Gene

Genomics for MIR518D Gene

Genomic Locations for MIR518D Gene

Latest Assembly
chr19:53,734,877-53,734,963
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,238,131-54,238,217
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR518D Gene

Genes around MIR518D on UCSC Golden Path with GeneCards custom track
MIR518D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR518D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518D Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR518D Gene

Proteins for MIR518D Gene

Post-translational modifications for MIR518D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518D Gene

Domains & Families for MIR518D Gene

Gene Families for MIR518D Gene

genes like me logo Genes that share domains with MIR518D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR518D Gene

Function for MIR518D Gene

Gene Ontology (GO) - Molecular Function for MIR518D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MIR518D: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518D Gene

Localization for MIR518D Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR518D gene
Compartment Confidence
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR518D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR518D: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR518D Gene

Pathways & Interactions for MIR518D Gene

PathCards logo

SuperPathways for MIR518D Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR518D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR518D: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR518D Gene

Drugs & Compounds for MIR518D Gene

No Compound Related Data Available

Transcripts for MIR518D Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR518D Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000087207_9606 miRNA 22 5

RefSeq: NR_030197, NR_030198, NR_030208, NR_030211,

LncBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a,

miRBase: MIMAT0005456,

MirGeneDB: Hsa-Mir-430-P22_5p, Hsa-Mir-430-P45_5p, Hsa-Mir-430-P46_5p,

TarBase: hsa-miR-518d-5p, hsa-miR-520c-5p, hsa-miR-526a,

URS00001B6361_9606 miRNA 21 5

RefSeq: NR_030211,

LncBase: hsa-miR-518d-3p,

miRBase: MIMAT0002864,

TarBase: hsa-miR-518d-3p,

ENA: AY785916.1:1..21:ncRNA,

URS00006DAC3B_9606 pre_miRNA 87 4

RefSeq: NR_030211,

Ensembl: ENST00000385014 (view in UCSC) ,

miRBase: MI0003171,

Rfam: RF00639,

URS000041D720_9606 miRNA 21 2

MirGeneDB: Hsa-Mir-430-P33_5p,

ENA: AY882336.1:1..21:ncRNA,

URS0001BC5BC8_9606 pre_miRNA 87 1

Rfam: RF00639,

MIR518D in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR518D Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518D Gene

No ASD Table

Relevant External Links for MIR518D Gene

GeneLoc Exon Structure for
MIR518D

Expression for MIR518D Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR518D Gene

Orthologs for MIR518D Gene

Evolution for MIR518D Gene

ENSEMBL:
Gene Tree for MIR518D (if available)
TreeFam:
Gene Tree for MIR518D (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR518D

No data available for Orthologs for MIR518D Gene

Paralogs for MIR518D Gene

No data available for Paralogs for MIR518D Gene

Variants for MIR518D Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR518D Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR518D Gene

Variant ID Type Subtype PubMed ID
esv2448351 CNV deletion 19546169
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR518D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR518D
Leiden Open Variation Database (LOVD)
MIR518D

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR518D Gene

Disorders for MIR518D Gene

MalaCards: The human disease database

(11) MalaCards diseases for MIR518D Gene - From: COP and GCD

Disorder Aliases PubMed IDs
reproductive system disease
  • genital system disease
female reproductive system disease
  • genital diseases, female
acute hemorrhagic conjunctivitis
  • apollo disease
gestational diabetes
  • gdm
endocrine gland cancer
  • endocrine neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR518D

genes like me logo Genes that share disorders with MIR518D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR518D Gene

Publications for MIR518D Gene

  1. DLL3 is regulated by LIN28B and miR-518d-5p and regulates cell proliferation, migration and chemotherapy response in advanced small cell lung cancer. (PMID: 31079917) Huang J … Han S (Biochemical and biophysical research communications 2019) 3
  2. MicroRNA-518d regulates PPARα protein expression in the placentas of females with gestational diabetes mellitus. (PMID: 24639097) Zhao C … Ling X (Molecular medicine reports 2014) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  5. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I … Bentwich Z (Nature genetics 2005) 3

Products for MIR518D Gene

Sources for MIR518D Gene