microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR518C Gene

RNA type for MIR518C Gene

miRNA

Aliases for MIR518C Gene

External Ids for MIR518C Gene

Previous HGNC Symbols for MIR518C Gene

  • MIRN518C

Previous GeneCards Identifiers for MIR518C Gene

  • GC19P058938
  • GC19P059002
  • GC19P054212
  • GC19P054218
  • GC19P054258
  • GC19P054313
  • GC19P054335
  • GC19P054406
  • GC19P054483
  • GC19P053709
  • GC19P053738
  • GC19P053979
  • GC19P054012
  • GC19P054035
  • GC19P054096
  • GC19P053776
  • GC19P053812
  • GC19P053815
  • GC19P053824
  • GC19P053845
  • GC19P053887
  • GC19P053922
  • GC19P053954
  • GC19P054612
  • GC19P055561

Summaries for MIR518C Gene

Entrez Gene Summary for MIR518C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518C Gene

MIR518C (MicroRNA 518c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR518C include Ependymoblastoma and Central Nervous System Primitive Neuroectodermal Neoplasm.

Rfam classification for MIR518C Gene

Additional gene information for MIR518C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR518C Gene

Genomics for MIR518C Gene

Genomic Locations for MIR518C Gene

Latest Assembly
chr19:53,708,735-53,708,835
(GRCh38/hg38)
Size:
101 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,211,989-54,212,089
(GRCh37/hg19 by Entrez Gene)
Size:
101 bases
Orientation:
Plus strand

Genomic View for MIR518C Gene

Genes around MIR518C on UCSC Golden Path with GeneCards custom track
MIR518C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR518C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518C Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR518C Gene

Proteins for MIR518C Gene

Post-translational modifications for MIR518C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518C Gene

Domains & Families for MIR518C Gene

Gene Families for MIR518C Gene

genes like me logo Genes that share domains with MIR518C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR518C Gene

Function for MIR518C Gene

Phenotypes From GWAS Catalog for MIR518C Gene

Gene Ontology (GO) - Molecular Function for MIR518C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22203747
genes like me logo Genes that share ontologies with MIR518C: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518C Gene

Localization for MIR518C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR518C gene
Compartment Confidence
extracellular 1

Gene Ontology (GO) - Cellular Components for MIR518C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR518C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR518C Gene

Pathways & Interactions for MIR518C Gene

PathCards logo

SuperPathways for MIR518C Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR518C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0035195 gene silencing by miRNA IDA, IEA --
genes like me logo Genes that share ontologies with MIR518C: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR518C Gene

Drugs & Compounds for MIR518C Gene

No Compound Related Data Available

Transcripts for MIR518C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR518C Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000003B660_9606 miRNA 23 4

RefSeq: NR_030199,

LncBase: hsa-miR-518c-5p,

miRBase: MIMAT0002847,

TarBase: hsa-miR-518c-5p,

URS000075EEDB_9606 pre_miRNA 101 3

RefSeq: NR_030199,

Ensembl: ENST00000384822 (view in UCSC) ,

miRBase: MI0003159,

URS0000759F7E_9606 miRNA 23 2

RefSeq: NR_030199,

miRBase: MIMAT0002848,

URS000001156F_9606 miRNA 22 2

MirGeneDB: Hsa-Mir-430-P21_3p,

ENA: AY785931.1:1..22:ncRNA,

URS00006D9320_9606 pre_miRNA 87 1

Rfam: RF00639,

MIR518C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR518C Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518C Gene

No ASD Table

Relevant External Links for MIR518C Gene

GeneLoc Exon Structure for
MIR518C

Expression for MIR518C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR518C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR518C

genes like me logo Genes that share expression patterns with MIR518C: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR518C Gene

Orthologs for MIR518C Gene

Evolution for MIR518C Gene

ENSEMBL:
Gene Tree for MIR518C (if available)
TreeFam:
Gene Tree for MIR518C (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR518C

No data available for Orthologs for MIR518C Gene

Paralogs for MIR518C Gene

No data available for Paralogs for MIR518C Gene

Variants for MIR518C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR518C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR518C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR518C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR518C
Leiden Open Variation Database (LOVD)
MIR518C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR518C Gene

Disorders for MIR518C Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR518C Gene - From: COP

Disorder Aliases PubMed IDs
ependymoblastoma
  • embryonal tumor with multilayered rosettes
central nervous system primitive neuroectodermal neoplasm
  • cpnet
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR518C

genes like me logo Genes that share disorders with MIR518C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR518C Gene

Publications for MIR518C Gene

  1. Roles of DANCR/microRNA-518a-3p/MDMA ceRNA network in the growth and malignant behaviors of colon cancer cells. (PMID: 32423468) Sun Y … Zhou J (BMC cancer 2020) 3
  2. Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. (PMID: 29793321) Feng C … Liu S (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  3. Serum miR-518e-5p is a potential biomarker for secondary imatinib-resistant gastrointestinal stromal tumor. (PMID: 30541960) Kou Y … Wang Q (Journal of biosciences 2018) 3
  4. MicroRNA Species in Follicular Fluid Associating With Polycystic Ovary Syndrome and Related Intermediary Phenotypes. (PMID: 26771704) Sørensen AE … Dalgaard LT (The Journal of clinical endocrinology and metabolism 2016) 3
  5. Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population. (PMID: 24687999) Chen J … Yang S (American journal of hypertension 2014) 3

Products for MIR518C Gene

Sources for MIR518C Gene