microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR518C Gene

Subcategory (RNA class) for MIR518C Gene

miRNA

Quality Score for this RNA gene is

17

Aliases for MIR518C Gene

  • MicroRNA 518c 2 3 5
  • Hsa-MiR-518c-5p 168 179
  • Hsa-Mir-518c 3
  • MIMAT0002848 53
  • MIMAT0002847 53
  • MI0003159 53
  • MIRN518C 3
  • MiR-518 3
  • RF00639 174
  • MIR518C 2

External Ids for MIR518C Gene

Previous HGNC Symbols for MIR518C Gene

  • MIRN518C

Previous GeneCards Identifiers for MIR518C Gene

  • GC19P058938
  • GC19P059002
  • GC19P054212
  • GC19P054218
  • GC19P054258
  • GC19P054313
  • GC19P054335
  • GC19P054406
  • GC19P054483
  • GC19P053709
  • GC19P053738
  • GC19P053979
  • GC19P054012
  • GC19P053776
  • GC19P053812
  • GC19P053815
  • GC19P053824
  • GC19P053845
  • GC19P053887
  • GC19P053922
  • GC19P053954

Summaries for MIR518C Gene

Entrez Gene Summary for MIR518C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518C Gene

MIR518C (MicroRNA 518c) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR518C Gene

Additional gene information for MIR518C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR518C Gene

Genomics for MIR518C Gene

Genomic Locations for MIR518C Gene

Genomic Locations for MIR518C Gene
chr19:53,708,735-53,708,835
(GRCh38/hg38)
Size:
101 bases
Orientation:
Plus strand
chr19:54,211,989-54,212,089
(GRCh37/hg19)
Size:
101 bases
Orientation:
Plus strand

Genomic View for MIR518C Gene

Genes around MIR518C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR518C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518C Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR518C Gene

Proteins for MIR518C Gene

Post-translational modifications for MIR518C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518C Gene

Domains & Families for MIR518C Gene

Gene Families for MIR518C Gene

genes like me logo Genes that share domains with MIR518C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR518C Gene

Function for MIR518C Gene

Gene Ontology (GO) - Molecular Function for MIR518C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22203747
genes like me logo Genes that share ontologies with MIR518C: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518C Gene

Localization for MIR518C Gene

Gene Ontology (GO) - Cellular Components for MIR518C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016442 RISC complex IEA --
genes like me logo Genes that share ontologies with MIR518C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR518C Gene

Pathways & Interactions for MIR518C Gene

PathCards logo

SuperPathways for MIR518C Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR518C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR518C: view

No data available for Pathways by source and SIGNOR curated interactions for MIR518C Gene

Drugs & Compounds for MIR518C Gene

No Compound Related Data Available

Transcripts for MIR518C Gene

mRNA/cDNA for MIR518C Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
(6) RNACentral transcripts :
(1) Rfam transcripts :
(2) ENA transcripts :
(3) miRBase transcripts :
(1) LncBase transcripts :
(1) TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518C Gene

No ASD Table

Relevant External Links for MIR518C Gene

GeneLoc Exon Structure for
MIR518C
ECgene alternative splicing isoforms for
MIR518C

Expression for MIR518C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR518C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR518C Gene:

MIR518C
genes like me logo Genes that share expression patterns with MIR518C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR518C Gene

Orthologs for MIR518C Gene

Evolution for MIR518C Gene

ENSEMBL:
Gene Tree for MIR518C (if available)
TreeFam:
Gene Tree for MIR518C (if available)

No data available for Orthologs for MIR518C Gene

Paralogs for MIR518C Gene

No data available for Paralogs for MIR518C Gene

Variants for MIR518C Gene

Sequence variations from dbSNP and Humsavar for MIR518C Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000321090 -- 53,709,186(+) C/T downstream_transcript_variant
rs1000385722 -- 53,707,154(+) A/G upstream_transcript_variant
rs1002282558 -- 53,708,118(+) G/C upstream_transcript_variant
rs1003283956 -- 53,709,239(+) G/C downstream_transcript_variant
rs1003664802 -- 53,706,803(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR518C Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR518C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR518C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR518C Gene

Disorders for MIR518C Gene

Additional Disease Information for MIR518C

No disorders were found for MIR518C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR518C Gene

Publications for MIR518C Gene

  1. Micro RNA-518 inhibits gastric cancer cell growth by inducing apoptosis via targeting MDM2. (PMID: 29793321) Feng C … Liu S (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3 56
  2. Serum miR-518e-5p is a potential biomarker for secondary imatinib-resistant gastrointestinal stromal tumor. (PMID: 30541960) Kou Y … Wang Q (Journal of biosciences 2018) 3 56
  3. MicroRNA Species in Follicular Fluid Associating With Polycystic Ovary Syndrome and Related Intermediary Phenotypes. (PMID: 26771704) Sørensen AE … Dalgaard LT (The Journal of clinical endocrinology and metabolism 2016) 3 56
  4. Common variants in TGFBR2 and miR-518 genes are associated with hypertension in the Chinese population. (PMID: 24687999) Chen J … Yang S (American journal of hypertension 2014) 3 56
  5. Hydroxysteroid (17-β) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia. (PMID: 22203747) Ishibashi O … Takizawa T (Hypertension (Dallas, Tex. : 1979) 2012) 3 56

Products for MIR518C Gene

Sources for MIR518C Gene