microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR518B Gene

Subcategory (RNA class) for MIR518B Gene

miRNA

Number of RNA Genes sources:

6 / 17

Aliases for MIR518B Gene

  • MicroRNA 518b 2 3 5
  • Hsa-Mir-518b 2 3
  • Hsa-MiR-518b 163 173
  • MIR518B 2 5
  • Hsa-Mir-430-P20 178
  • MIMAT0002844 50
  • MI0003156 50
  • MIRN518B 3
  • Mir-518b 3
  • RF00639 168

External Ids for MIR518B Gene

Previous HGNC Symbols for MIR518B Gene

  • MIRN518B

Previous GeneCards Identifiers for MIR518B Gene

  • GC19P058925
  • GC19P058997
  • GC19P054205
  • GC19P053705
  • GC19P053735
  • GC19P053968
  • GC19P053998
  • GC19P054039
  • GC19P054100
  • GC19P053768
  • GC19P053802
  • GC19P053838
  • GC19P053847
  • GC19P053873
  • GC19P053901
  • GC19P053929
  • GC19P053942

Summaries for MIR518B Gene

Entrez Gene Summary for MIR518B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR518B Gene

MIR518B (MicroRNA 518b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR518B include Psoriasis and Systemic Lupus Erythematosus.

Rfam classification for MIR518B Gene

Additional gene information for MIR518B Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR518B Gene

Genomics for MIR518B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR518B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR518B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR518B Gene

Genomic Locations for MIR518B Gene
chr19:53,702,735-53,702,821
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand
chr19:54,205,991-54,206,073
(GRCh37/hg19)
Size:
83 bases
Orientation:
Plus strand

Genomic View for MIR518B Gene

Genes around MIR518B on UCSC Golden Path with GeneCards custom track
MIR518B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
MIR518B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR518B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR518B Gene

Proteins for MIR518B Gene

Post-translational modifications for MIR518B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR518B Gene

Domains & Families for MIR518B Gene

Gene Families for MIR518B Gene

genes like me logo Genes that share domains with MIR518B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR518B Gene

Function for MIR518B Gene

Gene Ontology (GO) - Molecular Function for MIR518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 22958893
genes like me logo Genes that share ontologies with MIR518B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR518B Gene

Localization for MIR518B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR518B gene
Compartment Confidence
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MIR518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MIR518B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for MIR518B Gene

Pathways & Interactions for MIR518B Gene

PathCards logo

SuperPathways for MIR518B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR518B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 22958893
GO:0030336 negative regulation of cell migration IDA 22958893
GO:0030857 negative regulation of epithelial cell differentiation IMP 24383669
GO:0035195 gene silencing by miRNA IDA,IEA --
GO:0035278 miRNA mediated inhibition of translation IDA 22958893
genes like me logo Genes that share ontologies with MIR518B: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR518B Gene

Drugs & Compounds for MIR518B Gene

No Compound Related Data Available

Transcripts for MIR518B Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR518B Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00003676C9_9606 miRNA 22 6

RefSeq: NR_030196,

LncBase: hsa-miR-518b,

miRBase: MIMAT0002844,

MirGeneDB: Hsa-Mir-430-P20_3p,

TarBase: hsa-miR-518b,

ENA: AY785930.1:1..22:ncRNA, LM379784.1:1..22:ncRNA, LM609479.1:51..72:ncRNA,

URS000075A310_9606 precursor_RNA 83 5

HGNC: 32106,

RefSeq: NR_030196,

Ensembl: ENST00000385127 (view in UCSC) ,

miRBase: MI0003156,

ENA: LM609479.1:1..83:precursor_RNA,

URS0000642249_9606 precursor_RNA 87 1

Rfam: RF00639,

URS0000EFD61A_9606 precursor_RNA 60 1

MirGeneDB: Hsa-Mir-430-P20,

URS0000EFC6A8_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-430-P20_5p,

MIR518B in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR518B Gene

2 NCBI additional mRNA sequence :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR518B Gene

No ASD Table

Relevant External Links for MIR518B Gene

GeneLoc Exon Structure for
MIR518B

Expression for MIR518B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR518B

No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR518B Gene

Orthologs for MIR518B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR518B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-518b 31
  • 100 (a)
OneToOne
Species where no ortholog for MIR518B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR518B Gene

ENSEMBL:
Gene Tree for MIR518B (if available)
TreeFam:
Gene Tree for MIR518B (if available)

Paralogs for MIR518B Gene

No data available for Paralogs for MIR518B Gene

Variants for MIR518B Gene

Additional dbSNP identifiers (rs#s) for MIR518B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR518B Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR518B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR518B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR518B Gene

Disorders for MIR518B Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIR518B Gene - From: miR2Disease and DISEASES

Disorder Aliases PubMed IDs
psoriasis
systemic lupus erythematosus
  • sle
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MIR518B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR518B Gene

Publications for MIR518B Gene

  1. Altered levels of placental miR-338-3p and miR-518b are associated with acute chorioamnionitis and IL6 genotype. (PMID: 31174625) Konwar C … Robinson WP (Placenta 2019) 3
  2. MicroRNA‑518b functions as a tumor suppressor in glioblastoma by targeting PDGFRB. (PMID: 28849154) Xu X … Ying Q (Molecular medicine reports 2017) 3
  3. Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation. (PMID: 26040940) Hasegawa Y … Masuzaki H (Reproductive sciences (Thousand Oaks, Calif.) 2015) 3
  4. miR-18b and miR-518b Target FOXN1 during epithelial lineage differentiation in pluripotent cells. (PMID: 24383669) Kushwaha R … Chaganti RS (Stem cells and development 2014) 3
  5. Gallic acid induces apoptosis and inhibits cell migration by upregulating miR-518b in SW1353 human chondrosarcoma cells. (PMID: 24173143) Liang W … Liao L (International journal of oncology 2014) 3

Products for MIR518B Gene

Sources for MIR518B Gene