Free for academic non-profit institutions. Other users need a Commercial license
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR518A1 (MicroRNA 518a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR518A1 include Malignant Conjunctival Melanoma and Conjunctival Cancer.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003674 | molecular_function | ND | -- |
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20829195 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008150 | biological_process | ND | -- |
GO:0035195 | gene silencing by miRNA | IDA,IEA | -- |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS0000724CB9_9606 | precursor_RNA | 85 | 5 |
RefSeq: NR_030210, Ensembl: ENST00000385068 (view in UCSC) , miRBase: MI0003170, Rfam: RF00639, |
URS0000024ACC_9606 | miRNA | 22 | 5 |
LncBase: hsa-miR-518a-3p, miRBase: MIMAT0002863, TarBase: hsa-miR-518a-3p, ENA: LM379792.1:1..22:ncRNA, LM609488.1:51..72:ncRNA, LM609490.1:53..74:ncRNA, |
URS0000068BEA_9606 | miRNA | 20 | 5 |
RefSeq: NR_030210, NR_030213, NR_030219, LncBase: hsa-miR-518a-5p, hsa-miR-527, miRBase: MIMAT0005457, TarBase: hsa-miR-518a-5p, hsa-miR-527, |
URS00001BD821_9606 | miRNA | 21 | 2 |
MirGeneDB: Hsa-Mir-430-P48_5p, ENA: AY882297.1:1..21:ncRNA, |
URS0000EFEC7D_9606 | precursor_RNA | 61 | 1 |
MirGeneDB: Hsa-Mir-430-P18, |
This gene was present in the common ancestor of human and chimp.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | -- 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2448351 | CNV | deletion | 19546169 |
esv2718812 | CNV | deletion | 23290073 |
esv2718833 | CNV | deletion | 23290073 |
esv2718837 | CNV | deletion | 23290073 |
nsv458781 | CNV | gain | 19166990 |
nsv580108 | CNV | gain | 21841781 |
nsv961246 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
malignant conjunctival melanoma |
|
|
conjunctival cancer |
|
|
conjunctival disease |
|
|
gastrointestinal system cancer |
|
|
pancreatic cystadenocarcinoma |
|
|