microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5189 Gene

Data sources for MIR5189 Gene:

Subcategory (RNA class) for MIR5189 Gene

miRNA

Aliases for MIR5189 Gene

External Ids for MIR5189 Gene

Previous GeneCards Identifiers for MIR5189 Gene

  • GC16U901385
  • GC16P088537

Summaries for MIR5189 Gene

Entrez Gene Summary for MIR5189 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5189 Gene

MIR5189 (MicroRNA 5189) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5189 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5189 Gene

Genomics for MIR5189 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5189 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J088466 Enhancer 0.7 dbSUPER 250.7 -1.7 -1654 1.2 BHLHE40 VEZF1 RXRA HDAC2 HNF4A NRF1 ZBTB33 HDAC1 ARID1B MLLT1 MIR5189 ZFPM1-AS1 ZFPM1 ZC3H18
GH16J088452 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 -14.0 -13982 6 CHD2 TBP ZBTB10 MXD4 MNT SMAD5 IRF2 HES1 ZFP64 MBD2 ZFPM1 RNF166 ZCCHC14 ENSG00000260121 ZC3H18 SNAI3 MIR5189
GH16J088468 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 0.7 +2.5 2470 6.4 MNT ZNF217 BHLHE40 ZNF395 REST MAX VEZF1 SMAD4 ZEB2 RXRA ZC3H18 ENSG00000268218 LINC00304 ENSG00000259877 BANP RNF166 ZFPM1 ZFPM1-AS1 APRT CTU2
GH16J088464 Enhancer 0.9 ENCODE dbSUPER 0.7 -4.2 -4194 2.1 IKZF1 VEZF1 TAL1 ADNP FOSL1 PTBP1 MYC MAX ZBTB33 TEAD4 ZFPM1 ZFPM1-AS1 MIR5189 ZC3H18
GH16J088459 Enhancer 1 ENCODE dbSUPER 0.4 -7.6 -7560 3 IKZF1 SMAD5 ZNF217 ZIC2 VEZF1 SP2 MYNN TAL1 CBX1 PTBP1 ZFPM1 MIR5189 ZC3H18
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5189 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5189 Gene

Latest Assembly
chr16:88,468,918-88,469,031
(GRCh38/hg38)
Size:
114 bases
Orientation:
Plus strand

Previous Assembly
chr16:88,535,326-88,535,439
(GRCh37/hg19 by Entrez Gene)
Size:
114 bases
Orientation:
Plus strand

chr16:88,535,326-88,535,439
(GRCh37/hg19 by Ensembl)
Size:
114 bases
Orientation:
Plus strand

Genomic View for MIR5189 Gene

Genes around MIR5189 on UCSC Golden Path with GeneCards custom track
MIR5189 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR5189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5189 Gene

Proteins for MIR5189 Gene

Post-translational modifications for MIR5189 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5189 Gene

Domains & Families for MIR5189 Gene

Gene Families for MIR5189 Gene

HGNC:
genes like me logo Genes that share domains with MIR5189: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5189 Gene

Function for MIR5189 Gene

Phenotypes From GWAS Catalog for MIR5189 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5189 Gene

Localization for MIR5189 Gene

Gene Ontology (GO) - Cellular Components for MIR5189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space HDA 26646931
genes like me logo Genes that share ontologies with MIR5189: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR5189 Gene

Pathways & Interactions for MIR5189 Gene

PathCards logo

SuperPathways for MIR5189 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5189 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5189 Gene

Drugs & Compounds for MIR5189 Gene

No Compound Related Data Available

Transcripts for MIR5189 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5189 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000075DEEB_9606 precursor_RNA 114 4

RefSeq: NR_049821,

Ensembl: ENST00000577370 (view in UCSC) ,

miRBase: MI0018168,

ENA: LM611540.1:1..114:precursor_RNA,

URS00005CCD18_9606 miRNA 24 3

RefSeq: NR_049821,

miRBase: MIMAT0021120,

ENA: LM382909.1:1..24:ncRNA, LM611540.1:26..49:ncRNA,

URS000075B757_9606 miRNA 21 3

RefSeq: NR_049821,

miRBase: MIMAT0027088,

ENA: LM611540.1:67..87:ncRNA,

MIR5189 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR5189 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5189 Gene

No ASD Table

Relevant External Links for MIR5189 Gene

GeneLoc Exon Structure for
MIR5189

Expression for MIR5189 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5189 Gene

genes like me logo Genes that share expression patterns with MIR5189: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5189 Gene

Orthologs for MIR5189 Gene

Evolution for MIR5189 Gene

ENSEMBL:
Gene Tree for MIR5189 (if available)
TreeFam:
Gene Tree for MIR5189 (if available)

No data available for Orthologs for MIR5189 Gene

Paralogs for MIR5189 Gene

No data available for Paralogs for MIR5189 Gene

Variants for MIR5189 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR5189 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR5189 Gene

Variant ID Type Subtype PubMed ID
dgv171n21 CNV loss 19592680
dgv5293n54 CNV loss 21841781
esv2758669 CNV gain 17122850
nsv1061590 CNV gain 25217958
nsv471111 CNV loss 18288195
nsv471112 CNV gain 18288195
nsv528456 CNV loss 19592680
nsv817747 CNV loss 17921354
nsv952070 CNV deletion 24416366

Additional Variant Information for MIR5189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5189

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR5189 Gene

Disorders for MIR5189 Gene

Additional Disease Information for MIR5189

No disorders were found for MIR5189 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5189 Gene

Publications for MIR5189 Gene

  1. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3
  2. The repertoire and features of human platelet microRNAs. (PMID: 23226537) Plé H … Provost P (PloS one 2012) 3
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  4. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D … den Boer ML (Leukemia 2011) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR5189 Gene

Sources for MIR5189 Gene