microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5186 Gene

Subcategory (RNA class) for MIR5186 Gene

miRNA

Number of RNA Genes sources:

1 / 14

Aliases for MIR5186 Gene

  • MicroRNA 5186 2 3 5
  • Hsa-Mir-5186 3
  • MIMAT0021116 51
  • MI0018165 51
  • MIR5186 2

External Ids for MIR5186 Gene

Previous GeneCards Identifiers for MIR5186 Gene

  • GC03U901832
  • GC03M151285

Summaries for MIR5186 Gene

Entrez Gene Summary for MIR5186 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5186 Gene

MIR5186 (MicroRNA 5186) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR5186 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5186 Gene

Genomics for MIR5186 Gene

GeneHancer (GH) Regulatory Elements for MIR5186 Gene

Promoters and enhancers for MIR5186 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J151568 Enhancer 0.6 Ensembl ENCODE 500.7 -1.9 -1906 1.8 ATF2 MXI1 ZNF335 PKNOX1 JUN ATF7 MIR5186 LINC02066 IGSF10 AADACL2-AS1
GH03J151537 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 0.3 +27.6 27572 2 USF1 MAX ZNF592 SPI1 E2F6 REST POLR2A L3MBTL2 RNF2 MZF1 IGSF10 LINC02066 piR-40476-048 MIR5186 AADACL2-AS1
GH03J151580 Enhancer 0.8 Ensembl ENCODE 0.4 -14.6 -14606 2.3 TCF12 CEBPB MEF2B JUND EBF1 EP300 STAT3 POLR2A FOXP2 MEIS2 MIR5186 IGSF10 AADACL2-AS1
GH03J151543 Enhancer 0.9 Ensembl ENCODE 0.4 +22.2 22194 1.6 ZNF341 ZNF316 NFIC ZBTB17 MAFF FOS MAFK CEBPB NFE2 NFE2L1 IGSF10 LINC02066 P2RY12 MIR5186 piR-40476-048 AADACL2-AS1
GH03J151562 Enhancer 0.4 Ensembl 0.7 +3.8 3794 0.4 RELA ZNF592 CAVIN1 ZNF740 IGSF10 MIR5186 piR-40476-048 AADACL2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5186 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR5186 Gene

Genomic Locations for MIR5186 Gene
chr3:151,565,876-151,565,995
(GRCh38/hg38)
Size:
120 bases
Orientation:
Minus strand
chr3:151,283,664-151,283,783
(GRCh37/hg19)
Size:
120 bases
Orientation:
Minus strand

Genomic View for MIR5186 Gene

Genes around MIR5186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR5186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5186 Gene

Proteins for MIR5186 Gene

Post-translational modifications for MIR5186 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5186 Gene

Domains & Families for MIR5186 Gene

Gene Families for MIR5186 Gene

HGNC:
genes like me logo Genes that share domains with MIR5186: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5186 Gene

Function for MIR5186 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5186 Gene

Localization for MIR5186 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5186 Gene

Pathways & Interactions for MIR5186 Gene

PathCards logo

SuperPathways for MIR5186 Gene

No Data Available
;

Gene Ontology (GO) - Biological Process for MIR5186 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5186 Gene

Drugs & Compounds for MIR5186 Gene

No Compound Related Data Available

Transcripts for MIR5186 Gene

mRNA/cDNA for MIR5186 Gene

2 RNACentral transcripts :
1 REFSEQ mRNAs :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
2 miRBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5186 Gene

No ASD Table

Relevant External Links for MIR5186 Gene

GeneLoc Exon Structure for
MIR5186

Expression for MIR5186 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5186 Gene

genes like me logo Genes that share expression patterns with MIR5186: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5186 Gene

Orthologs for MIR5186 Gene

Evolution for MIR5186 Gene

ENSEMBL:
Gene Tree for MIR5186 (if available)
TreeFam:
Gene Tree for MIR5186 (if available)

No data available for Orthologs for MIR5186 Gene

Paralogs for MIR5186 Gene

No data available for Paralogs for MIR5186 Gene

Variants for MIR5186 Gene

Additional dbSNP identifiers (rs#s) for MIR5186 Gene

Additional Variant Information for MIR5186 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5186

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR5186 Gene

Disorders for MIR5186 Gene

Additional Disease Information for MIR5186

No disorders were found for MIR5186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR5186 Gene

Publications for MIR5186 Gene

  1. Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia. (PMID: 21606961) Schotte D … den Boer ML (Leukemia 2011) 3 54
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 54

Products for MIR5186 Gene

Sources for MIR5186 Gene