microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR517C Gene

RNA type for MIR517C Gene

miRNA

Aliases for MIR517C Gene

External Ids for MIR517C Gene

Previous HGNC Symbols for MIR517C Gene

  • MIRN517C

Previous GeneCards Identifiers for MIR517C Gene

  • GC19P058975
  • GC19P059018
  • GC19P054247
  • GC19P054250
  • GC19P054300
  • GC19P054328
  • GC19P054348
  • GC19P054420
  • GC19P054501
  • GC19P053742
  • GC19P053771
  • GC19P053990
  • GC19P054021
  • GC19P054044
  • GC19P054118
  • GC19P053805
  • GC19P053832
  • GC19P053856
  • GC19P053871
  • GC19P053883
  • GC19P053906
  • GC19P053932
  • GC19P053960
  • GC19P054628
  • GC19P055573

Summaries for MIR517C Gene

Entrez Gene Summary for MIR517C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR517C Gene

MIR517C (MicroRNA 517c) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR517C Gene

Additional gene information for MIR517C Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR517C Gene

Genomics for MIR517C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR517C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR517C on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR517C Gene

Latest Assembly
chr19:53,741,313-53,741,407
(GRCh38/hg38)
Size:
95 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,244,567-54,244,661
(GRCh37/hg19 by Entrez Gene)
Size:
95 bases
Orientation:
Plus strand

chr19:54,244,567-54,244,661
(GRCh37/hg19 by Ensembl)
Size:
95 bases
Orientation:
Plus strand

Genomic View for MIR517C Gene

Genes around MIR517C on UCSC Golden Path with GeneCards custom track
MIR517C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR517C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR517C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR517C Gene

Proteins for MIR517C Gene

Post-translational modifications for MIR517C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR517C Gene

Domains & Families for MIR517C Gene

Gene Families for MIR517C Gene

genes like me logo Genes that share domains with MIR517C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR517C Gene

Function for MIR517C Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR517C Gene

Localization for MIR517C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR517C Gene

Pathways & Interactions for MIR517C Gene

PathCards logo

SuperPathways for MIR517C Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR517C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR517C: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR517C Gene

Drugs & Compounds for MIR517C Gene

No Compound Related Data Available

Transcripts for MIR517C Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR517C Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS0000227241_9606 miRNA 22 6

RefSeq: NR_030201, NR_030205, NR_030214,

LncBase: hsa-miR-517-5p,

miRBase: MIMAT0002851,

MirGeneDB: Hsa-Mir-430-P15a_5p, Hsa-Mir-430-P15b_5p, Hsa-Mir-430-P15c_5p,

TarBase: hsa-miR-517-5p,

ENA: AY882296.1:1..22:ncRNA, LM609481.1:15..36:ncRNA, LM609484.1:6..27:ncRNA,

URS00003FBECA_9606 miRNA 22 4

RefSeq: NR_030214,

miRBase: MIMAT0002866,

MirGeneDB: Hsa-Mir-430-P15c_3p,

ENA: AY785929.1:1..22:ncRNA,

URS0000759A4A_9606 pre_miRNA 95 3

RefSeq: NR_030214,

Ensembl: ENST00000385103 (view in UCSC) ,

miRBase: MI0003174,

URS000062A6EA_9606 pre_miRNA 85 1

Rfam: RF00639,

URS0001BC5434_9606 pre_miRNA 85 1

Rfam: RF00639,

MIR517C in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR517C Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR517C Gene

No ASD Table

Relevant External Links for MIR517C Gene

GeneLoc Exon Structure for
MIR517C

Expression for MIR517C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR517C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR517C

genes like me logo Genes that share expression patterns with MIR517C: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR517C Gene

Orthologs for MIR517C Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR517C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-517b-2 30
  • 99 (a)
OneToOne
Species where no ortholog for MIR517C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR517C Gene

ENSEMBL:
Gene Tree for MIR517C (if available)
TreeFam:
Gene Tree for MIR517C (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR517C

Paralogs for MIR517C Gene

No data available for Paralogs for MIR517C Gene

Variants for MIR517C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR517C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR517C Gene

Variant ID Type Subtype PubMed ID
esv2448351 CNV deletion 19546169
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
esv2718838 CNV deletion 23290073
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR517C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR517C
Leiden Open Variation Database (LOVD)
MIR517C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR517C Gene

Disorders for MIR517C Gene

Additional Disease Information for MIR517C

No disorders were found for MIR517C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR517C Gene

Publications for MIR517C Gene

  1. Up-regulation of miR-517-5p inhibits ERK/MMP-2 pathway: potential role in preeclampsia. (PMID: 30402831) Fu JY … Zhu YJ (European review for medical and pharmacological sciences 2018) 3
  2. MIR517C inhibits autophagy and the epithelial-to-mesenchymal (-like) transition phenotype in human glioblastoma through KPNA2-dependent disruption of TP53 nuclear translocation. (PMID: 26553592) Lu Y … Qi S (Autophagy 2015) 3
  3. Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. (PMID: 25799546) Anton L … Elovitz MA (PloS one 2015) 3
  4. Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2. (PMID: 23142219) Liu RF … Han ZG (Cancer letters 2013) 3
  5. Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors. (PMID: 19962671) Li M … Huang A (Cancer cell 2009) 3

Products for MIR517C Gene

Sources for MIR517C Gene