microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR517A Gene

RNA type for MIR517A Gene

miRNA

Aliases for MIR517A Gene

External Ids for MIR517A Gene

Previous HGNC Symbols for MIR517A Gene

  • MIRN517A

Previous GeneCards Identifiers for MIR517A Gene

  • GC19P058940
  • GC19P059004
  • GC19P054215

Summaries for MIR517A Gene

Entrez Gene Summary for MIR517A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR517A Gene

MIR517A (MicroRNA 517a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR517A include Mild Pre-Eclampsia and Placenta Disease.

Rfam classification for MIR517A Gene

Additional gene information for MIR517A Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR517A Gene

Genomics for MIR517A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR517A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR517A on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR517A Gene

Latest Assembly
chr19:53,712,268-53,712,354
(GRCh38/hg38)
Size:
87 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,215,522-54,215,608
(GRCh37/hg19 by Entrez Gene)
Size:
87 bases
Orientation:
Plus strand

chr19:54,215,522-54,215,608
(GRCh37/hg19 by Ensembl)
Size:
87 bases
Orientation:
Plus strand

Genomic View for MIR517A Gene

Genes around MIR517A on UCSC Golden Path with GeneCards custom track
MIR517A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR517A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR517A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR517A Gene

Proteins for MIR517A Gene

Post-translational modifications for MIR517A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR517A Gene

Domains & Families for MIR517A Gene

Gene Families for MIR517A Gene

genes like me logo Genes that share domains with MIR517A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR517A Gene

Function for MIR517A Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR517A Gene

Localization for MIR517A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR517A Gene

Pathways & Interactions for MIR517A Gene

PathCards logo

SuperPathways for MIR517A Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR517A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR517A: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR517A Gene

Drugs & Compounds for MIR517A Gene

No Compound Related Data Available

Transcripts for MIR517A Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR517A Gene

MIR517A in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR517A Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR517A Gene

No ASD Table

Relevant External Links for MIR517A Gene

GeneLoc Exon Structure for
MIR517A

Expression for MIR517A Gene

No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR517A Gene

Orthologs for MIR517A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR517A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-517a 30
  • 100 (a)
OneToOne
Species where no ortholog for MIR517A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR517A Gene

ENSEMBL:
Gene Tree for MIR517A (if available)
TreeFam:
Gene Tree for MIR517A (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR517A

Paralogs for MIR517A Gene

No data available for Paralogs for MIR517A Gene

Variants for MIR517A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR517A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR517A Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718836 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580107 CNV gain 21841781
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR517A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR517A
Leiden Open Variation Database (LOVD)
MIR517A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR517A Gene

Disorders for MIR517A Gene

MalaCards: The human disease database

(8) MalaCards diseases for MIR517A Gene - From: COP

Disorder Aliases PubMed IDs
mild pre-eclampsia
  • mild toxemia
placenta disease
  • placenta disorder
oligohydramnios
  • antepartum oligohydramnios
placental insufficiency
  • uteroplacental vascular insufficiency
arteries, anomalies of
  • artery disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR517A

genes like me logo Genes that share disorders with MIR517A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR517A Gene

Publications for MIR517A Gene

  1. miR-517a is up-regulated in glioma and promotes glioma tumorigenesis in vitro and in vivo. (PMID: 30962271) Du CL … Liu KQ (Bioscience reports 2019) 3
  2. Up-regulation of miR-517-5p inhibits ERK/MMP-2 pathway: potential role in preeclampsia. (PMID: 30402831) Fu JY … Zhu YJ (European review for medical and pharmacological sciences 2018) 3
  3. Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia. (PMID: 25799546) Anton L … Elovitz MA (PloS one 2015) 3
  4. Increased Levels of Cell-Free miR-517a and Decreased Levels of Cell-Free miR-518b in Maternal Plasma Samples From Placenta Previa Pregnancies at 32 Weeks of Gestation. (PMID: 26040940) Hasegawa Y … Masuzaki H (Reproductive sciences (Thousand Oaks, Calif.) 2015) 3
  5. MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression. (PMID: 24846831) Jin J … Zhang B (Life sciences 2014) 3

Products for MIR517A Gene

Sources for MIR517A Gene