microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR516B2 Gene

Data sources for MIR516B2 Gene:

RNA type for MIR516B2 Gene

miRNA

Aliases for MIR516B2 Gene

External Ids for MIR516B2 Gene

Previous HGNC Symbols for MIR516B2 Gene

  • MIRN516-3
  • MIRN516B2

Previous GeneCards Identifiers for MIR516B2 Gene

  • GC19P058954
  • GC19P059010
  • GC19P054231
  • GC19P054249
  • GC19P054296
  • GC19P054326
  • GC19P054346
  • GC19P054417
  • GC19P054499

Summaries for MIR516B2 Gene

Entrez Gene Summary for MIR516B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR516B2 Gene

MIR516B2 (MicroRNA 516b-2) is an RNA Gene, and is affiliated with the miRNA class.

Rfam classification for MIR516B2 Gene

Additional gene information for MIR516B2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR516B2 Gene

Genomics for MIR516B2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR516B2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR516B2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR516B2 Gene

Latest Assembly
chr19:53,725,442-53,725,526
(GRCh38/hg38)
Size:
85 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,228,696-54,228,780
(GRCh37/hg19 by Entrez Gene)
Size:
85 bases
Orientation:
Plus strand

chr19:54,228,696-54,228,780
(GRCh37/hg19 by Ensembl)
Size:
85 bases
Orientation:
Plus strand

Genomic View for MIR516B2 Gene

Genes around MIR516B2 on UCSC Golden Path with GeneCards custom track
MIR516B2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR516B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR516B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR516B2 Gene

Proteins for MIR516B2 Gene

Post-translational modifications for MIR516B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR516B2 Gene

Domains & Families for MIR516B2 Gene

Gene Families for MIR516B2 Gene

genes like me logo Genes that share domains with MIR516B2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR516B2 Gene

Function for MIR516B2 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR516B2 Gene

Localization for MIR516B2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR516B2 Gene

Pathways & Interactions for MIR516B2 Gene

PathCards logo

SuperPathways for MIR516B2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR516B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IEA --
genes like me logo Genes that share ontologies with MIR516B2: view

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR516B2 Gene

Drugs & Compounds for MIR516B2 Gene

No Compound Related Data Available

Transcripts for MIR516B2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR516B2 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS00006D6272_9606 pre_miRNA 85 5

RefSeq: NR_030207,

Ensembl: ENST00000385190 (view in UCSC) ,

miRBase: MI0003167,

Rfam: RF00639,

ENA: LM609486.1:1..85:precursor_RNA,

URS000005E7DD_9606 miRNA 22 5

RefSeq: NR_030207, NR_030212,

LncBase: hsa-miR-516b-5p,

miRBase: MIMAT0002859,

TarBase: hsa-miR-516b-5p,

ENA: LM379791.1:1..22:ncRNA, LM609486.1:16..37:ncRNA, LM609489.1:16..37:ncRNA,

URS0000205A39_9606 miRNA 18 3

RefSeq: NR_030207, NR_030212, NR_030220, NR_030221,

miRBase: MIMAT0002860,

ENA: AY882299.1:1..18:ncRNA, LM609486.1:56..73:ncRNA, LM609489.1:61..78:ncRNA, LM609494.1:61..78:ncRNA, LM609495.1:61..78:ncRNA,

URS0001BC5781_9606 pre_miRNA 85 1

Rfam: RF00639,

URS0000EFC290_9606 pre_miRNA 59 1

MirGeneDB: Hsa-Mir-430-P14,

MIR516B2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR516B2 Gene

2 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR516B2 Gene

No ASD Table

Relevant External Links for MIR516B2 Gene

GeneLoc Exon Structure for
MIR516B2

Expression for MIR516B2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR516B2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR516B2

genes like me logo Genes that share expression patterns with MIR516B2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR516B2 Gene

Orthologs for MIR516B2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR516B2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-516b-2 30
  • 94 (a)
OneToOne
Species where no ortholog for MIR516B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR516B2 Gene

ENSEMBL:
Gene Tree for MIR516B2 (if available)
TreeFam:
Gene Tree for MIR516B2 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR516B2

Paralogs for MIR516B2 Gene

No data available for Paralogs for MIR516B2 Gene

Variants for MIR516B2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR516B2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR516B2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2718833 CNV deletion 23290073
esv2718837 CNV deletion 23290073
esv2762049 CNV gain 21179565
nsv458781 CNV gain 19166990
nsv580108 CNV gain 21841781
nsv961246 CNV duplication 23825009

Additional Variant Information for MIR516B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR516B2
Leiden Open Variation Database (LOVD)
MIR516B2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR516B2 Gene

Disorders for MIR516B2 Gene

Additional Disease Information for MIR516B2

No disorders were found for MIR516B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR516B2 Gene

Publications for MIR516B2 Gene

  1. miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous cell carcinoma. (PMID: 30119241) Zhao Y … Xing G (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3
  5. Identification of hundreds of conserved and nonconserved human microRNAs. (PMID: 15965474) Bentwich I … Bentwich Z (Nature genetics 2005) 3

Products for MIR516B2 Gene

Sources for MIR516B2 Gene