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Aliases for MIR515-1 Gene

Subcategory (RNA class) for MIR515-1 Gene


Quality Score for this RNA gene is


Aliases for MIR515-1 Gene

  • MicroRNA 515-1 2 3 5
  • Hsa-Mir-515-1 3
  • MIRN515-1 3

External Ids for MIR515-1 Gene

ORGUL Members for MIR515-1 Gene

Previous HGNC Symbols for MIR515-1 Gene

  • MIRN515-1

Previous GeneCards Identifiers for MIR515-1 Gene

  • GC19P058876
  • GC19P054182

Summaries for MIR515-1 Gene

Entrez Gene Summary for MIR515-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR515-1 Gene

MIR515-1 (MicroRNA 515-1) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR515-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR515-1 Gene

Genomics for MIR515-1 Gene

GeneHancer (GH) Regulatory Elements for MIR515-1 Gene

Promoters and enhancers for MIR515-1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053840 Enhancer 1.1 Ensembl ENCODE 11.1 +163.1 163126 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF143 ZFP91 FOS ATF7 SP3 LOC105372457 ENSG00000232220 PRKCG CACNG6 MIR935 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19J053844 Enhancer 0.9 FANTOM5 Ensembl ENCODE 11.1 +166.1 166091 0.6 ZNF121 HLF CEBPB CEBPG ATF2 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR519C MIR515-1 MIR519E
GH19J053843 Enhancer 0.4 ENCODE 11.1 +164.9 164939 0.2 NFIL3 CREB1 EMSY LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR520A MIR1283-1 MIR515-2 MIR519C MIR515-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR515-1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR515-1 Gene

Genomic Locations for MIR515-1 Gene
83 bases
Plus strand
83 bases
Plus strand

Genomic View for MIR515-1 Gene

Genes around MIR515-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR515-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR515-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR515-1 Gene

Proteins for MIR515-1 Gene

Post-translational modifications for MIR515-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR515-1 Gene

Domains & Families for MIR515-1 Gene

Gene Families for MIR515-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR515-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR515-1 Gene

Function for MIR515-1 Gene

Gene Ontology (GO) - Molecular Function for MIR515-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR515-1: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR515-1 Gene

Localization for MIR515-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR515-1 Gene

Pathways & Interactions for MIR515-1 Gene

SuperPathways for MIR515-1 Gene

No Data Available

Interacting Proteins for MIR515-1 Gene

Gene Ontology (GO) - Biological Process for MIR515-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IMP 20190813
GO:0035195 gene silencing by miRNA IDA 20190813
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP 20190813
genes like me logo Genes that share ontologies with MIR515-1: view

No data available for Pathways by source and SIGNOR curated interactions for MIR515-1 Gene

Drugs & Compounds for MIR515-1 Gene

No Compound Related Data Available

Transcripts for MIR515-1 Gene

mRNA/cDNA for MIR515-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR515-1 Gene

No ASD Table

Relevant External Links for MIR515-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR515-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR515-1 Gene

genes like me logo Genes that share expression patterns with MIR515-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR515-1 Gene

Orthologs for MIR515-1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR515-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-515-1 34
  • 100 (a)
Species where no ortholog for MIR515-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR515-1 Gene

Gene Tree for MIR515-1 (if available)
Gene Tree for MIR515-1 (if available)

Paralogs for MIR515-1 Gene

No data available for Paralogs for MIR515-1 Gene

Variants for MIR515-1 Gene

Sequence variations from dbSNP and Humsavar for MIR515-1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000644546 -- 53,679,495(+) C/G/T downstream_transcript_variant
rs1000931683 -- 53,679,191(+) A/C downstream_transcript_variant
rs1002667248 -- 53,678,769(+) G/A upstream_transcript_variant
rs1006134078 -- 53,678,666(+) GG/G upstream_transcript_variant
rs1007746050 -- 53,677,962(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR515-1 Gene

Variant ID Type Subtype PubMed ID
nsv961246 CNV duplication 23825009
nsv580108 CNV gain 21841781
nsv580107 CNV gain 21841781
nsv458781 CNV gain 19166990
esv2762049 CNV gain 21179565
esv2718833 CNV deletion 23290073
esv2718812 CNV deletion 23290073

Additional Variant Information for MIR515-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR515-1 Gene

Disorders for MIR515-1 Gene

Additional Disease Information for MIR515-1

No disorders were found for MIR515-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR515-1 Gene

Publications for MIR515-1 Gene

  1. miR-515-5p controls cancer cell migration through MARK4 regulation. (PMID: 26882547) Pardo OE … Stebbing J (EMBO reports 2016) 3 58
  2. Downregulation of microRNA-515-5p by the estrogen receptor modulates sphingosine kinase 1 and breast cancer cell proliferation. (PMID: 23928990) Pinho FG … Castellano L (Cancer research 2013) 3 58
  3. Involvement of IGF-1R regulation by miR-515-5p modifies breast cancer risk among BRCA1 carriers. (PMID: 23549953) Gilam A … Shomron N (Breast cancer research and treatment 2013) 3 58
  4. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. (PMID: 20190813) Wu S … He X (Oncogene 2010) 3 58
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58

Products for MIR515-1 Gene

Sources for MIR515-1 Gene

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