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Aliases for MIR514A2 Gene

Subcategory (RNA class) for MIR514A2 Gene


Quality Score for this RNA gene is


Aliases for MIR514A2 Gene

  • MicroRNA 514a-2 2 3 5
  • MicroRNA 514-2 2 3
  • Hsa-Mir-514a-2 3
  • Hsa-Mir-514-2 3
  • MIRN514-2 3
  • MIR514-2 3

External Ids for MIR514A2 Gene

Previous HGNC Symbols for MIR514A2 Gene

  • MIRN514-2
  • MIR514-2

Previous GeneCards Identifiers for MIR514A2 Gene

  • GC0XM146367
  • GC0XM146370
  • GC0XM146376
  • GC0XM147282
  • GC0XM147287
  • GC0XM147288
  • GC0XM147289
  • GC0XM147290
  • GC0XM147291
  • GC0XM147292
  • GC0XM147293

Summaries for MIR514A2 Gene

Entrez Gene Summary for MIR514A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR514A2 Gene

MIR514A2 (MicroRNA 514a-2) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR514A2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR514A2 Gene

Genomics for MIR514A2 Gene

Genomic Locations for MIR514A2 Gene

Genomic Locations for MIR514A2 Gene
88 bases
Minus strand

Genomic View for MIR514A2 Gene

Genes around MIR514A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR514A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR514A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR514A2 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR514A2 Gene

Proteins for MIR514A2 Gene

Post-translational modifications for MIR514A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR514A2 Gene

Domains & Families for MIR514A2 Gene

Gene Families for MIR514A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR514A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR514A2 Gene

Function for MIR514A2 Gene

Gene Ontology (GO) - Molecular Function for MIR514A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23874542
genes like me logo Genes that share ontologies with MIR514A2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR514A2 Gene

Localization for MIR514A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR514A2 Gene

Pathways & Interactions for MIR514A2 Gene

SuperPathways for MIR514A2 Gene

No Data Available

Interacting Proteins for MIR514A2 Gene

Gene Ontology (GO) - Biological Process for MIR514A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 23874542
genes like me logo Genes that share ontologies with MIR514A2: view

No data available for Pathways by source and SIGNOR curated interactions for MIR514A2 Gene

Drugs & Compounds for MIR514A2 Gene

No Compound Related Data Available

Transcripts for MIR514A2 Gene

mRNA/cDNA for MIR514A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR514A2 Gene

No ASD Table

Relevant External Links for MIR514A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR514A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR514A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR514A2 Gene:

genes like me logo Genes that share expression patterns with MIR514A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR514A2 Gene

Orthologs for MIR514A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR514A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-514-4 34
  • 89 (a)
(Canis familiaris)
Mammalia cfa-mir-514 34
  • 86 (a)
Species where no ortholog for MIR514A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR514A2 Gene

Gene Tree for MIR514A2 (if available)
Gene Tree for MIR514A2 (if available)

Paralogs for MIR514A2 Gene

No data available for Paralogs for MIR514A2 Gene

Variants for MIR514A2 Gene

Sequence variations from dbSNP and Humsavar for MIR514A2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs111260230 -- 147,282,106(-) T/C upstream_transcript_variant
rs12009349 -- 147,281,575(-) A/G downstream_transcript_variant
rs140539321 -- 147,283,145(-) C/A/T upstream_transcript_variant
rs141066398 -- 147,281,743(-) G/A downstream_transcript_variant
rs144914736 -- 147,281,751(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR514A2 Gene

Variant ID Type Subtype PubMed ID
esv22917 CNV gain+loss 19812545
esv2758898 CNV gain 17122850
esv3356512 CNV duplication 20981092
esv35128 CNV gain 17911159
esv3574899 CNV loss 25503493
esv3577461 CNV gain 25503493
esv999927 CNV loss 20482838
nsv1077599 CNV duplication 25765185
nsv1125132 CNV duplication 24896259
nsv1151566 CNV duplication 26484159
nsv216 CNV insertion 15895083
nsv508808 CNV insertion 20534489
nsv521982 CNV gain 19592680
nsv522113 CNV gain 19592680
nsv7138 CNV insertion 18451855
nsv953700 CNV duplication 24416366
nsv9988 CNV gain+loss 18304495

Additional Variant Information for MIR514A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR514A2 Gene

Disorders for MIR514A2 Gene

Additional Disease Information for MIR514A2

No disorders were found for MIR514A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR514A2 Gene

Publications for MIR514A2 Gene

  1. Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors. (PMID: 28471449) Özata DM … Lui WO (Cell death & disease 2017) 3 58
  2. miR-514a regulates the tumour suppressor NF1 and modulates BRAFi sensitivity in melanoma. (PMID: 25980496) Stark MS … Hayward NK (Oncotarget 2015) 3 58
  3. Large-scale screens of miRNA-mRNA interactions unveiled that the 3'UTR of a gene is targeted by multiple miRNAs. (PMID: 23874542) Zhou P … Jiang S (PloS one 2013) 3 58
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR514A2 Gene

Sources for MIR514A2 Gene

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