microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR513A1 Gene

Data sources for MIR513A1 Gene:

Subcategory (RNA class) for MIR513A1 Gene

miRNA

Aliases for MIR513A1 Gene

External Ids for MIR513A1 Gene

Previous HGNC Symbols for MIR513A1 Gene

  • MIRN513-1
  • MIRN513A1

Previous GeneCards Identifiers for MIR513A1 Gene

  • GC0XM146104
  • GC0XM146294

Summaries for MIR513A1 Gene

Entrez Gene Summary for MIR513A1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR513A1 Gene

MIR513A1 (MicroRNA 513a-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR513A1 include Retinoblastoma and Adrenal Medulla Cancer.

Additional gene information for MIR513A1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR513A1 Gene

Genomics for MIR513A1 Gene

Genomic Locations for MIR513A1 Gene

Latest Assembly
chrX:147,213,463-147,213,591
(GRCh38/hg38)
Size:
129 bases
Orientation:
Minus strand

Previous Assembly
chrX:146,294,981-146,295,109
(GRCh37/hg19 by Entrez Gene)
Size:
129 bases
Orientation:
Minus strand

chrX:146,294,981-146,295,109
(GRCh37/hg19 by Ensembl)
Size:
129 bases
Orientation:
Minus strand

Genomic View for MIR513A1 Gene

Genes around MIR513A1 on UCSC Golden Path with GeneCards custom track
MIR513A1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR513A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR513A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR513A1 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR513A1 Gene

Proteins for MIR513A1 Gene

Post-translational modifications for MIR513A1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR513A1 Gene

Domains & Families for MIR513A1 Gene

Gene Families for MIR513A1 Gene

genes like me logo Genes that share domains with MIR513A1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR513A1 Gene

Function for MIR513A1 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR513A1 Gene

Localization for MIR513A1 Gene

Gene Ontology (GO) - Cellular Components for MIR513A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903561 extracellular vesicle HDA 28798470
genes like me logo Genes that share ontologies with MIR513A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR513A1 Gene

Pathways & Interactions for MIR513A1 Gene

PathCards logo

SuperPathways for MIR513A1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR513A1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR513A1 Gene

Drugs & Compounds for MIR513A1 Gene

No Compound Related Data Available

Transcripts for MIR513A1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR513A1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00004BCE9B_9606 miRNA 23 6

RefSeq: NR_030231, NR_030232,

LncBase: hsa-miR-513a-3p,

miRBase: MIMAT0004777,

MirGeneDB: Hsa-Mir-506-P6a1_3p, Hsa-Mir-506-P6a2_3p,

TarBase: hsa-miR-513a-3p,

ENA: LM380391.1:1..23:ncRNA, LM609505.1:72..94:ncRNA, LM609506.1:71..93:ncRNA,

URS0000357286_9606 miRNA 18 5

RefSeq: NR_030231, NR_030232,

LncBase: hsa-miR-513a-5p,

miRBase: MIMAT0002877,

TarBase: hsa-miR-513a-5p,

ENA: LM379801.1:1..18:ncRNA, LM609505.1:37..54:ncRNA, LM609506.1:36..53:ncRNA,

URS000075E43A_9606 precursor_RNA 129 4

RefSeq: NR_030231,

Ensembl: ENST00000385138 (view in UCSC) ,

miRBase: MI0003191,

ENA: LM609505.1:1..129:precursor_RNA,

URS0000EFDD0F_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-506-P6a2,

URS0000EFEAD9_9606 miRNA 23 1

MirGeneDB: Hsa-Mir-506-P6a1_5p, Hsa-Mir-506-P6a2_5p,

MIR513A1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR513A1 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR513A1 Gene

No ASD Table

Relevant External Links for MIR513A1 Gene

GeneLoc Exon Structure for
MIR513A1

Expression for MIR513A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR513A1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR513A1

genes like me logo Genes that share expression patterns with MIR513A1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR513A1 Gene

Orthologs for MIR513A1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR513A1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-513a-2 31
  • 95 (a)
OneToOne
Species where no ortholog for MIR513A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR513A1 Gene

ENSEMBL:
Gene Tree for MIR513A1 (if available)
TreeFam:
Gene Tree for MIR513A1 (if available)

Paralogs for MIR513A1 Gene

No data available for Paralogs for MIR513A1 Gene

Variants for MIR513A1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR513A1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR513A1 Gene

Variant ID Type Subtype PubMed ID
esv2740574 CNV deletion 23290073
esv2758898 CNV gain 17122850
esv35128 CNV gain 17911159

Additional Variant Information for MIR513A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR513A1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR513A1 Gene

Disorders for MIR513A1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MIR513A1 Gene - From: MID and COP

Disorder Aliases PubMed IDs
retinoblastoma
  • rb1
adrenal medulla cancer
  • adrenal medulla neoplasm
testicular disease
  • disorder of testis
lung cancer
  • lung cancer, susceptibility to
esophageal disease
  • esophageal ulcer
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR513A1

genes like me logo Genes that share disorders with MIR513A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR513A1 Gene

Publications for MIR513A1 Gene

  1. [Deleted in lymphocytic leukemia 1 promoted proliferation and apoptosis of nephroblastoma cells through regulating miR-513a-5p and RANBP2 pathway]. (PMID: 33113626) Zhao JL … Zhang WL (Zhonghua zhong liu za zhi [Chinese journal of oncology] 2020) 3
  2. miR-513a-5p targets Bcl-2 to promote dichlorvos induced apoptosis in HK-2 cells. (PMID: 30372899) Li S … Wang JF (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018) 3
  3. Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. (PMID: 28798470) Enomoto Y … Miyajima A (Scientific reports 2017) 3
  4. Upregulation of miR-513b inhibits cell proliferation, migration, and promotes apoptosis by targeting high mobility group-box 3 protein in gastric cancer. (PMID: 25095979) Chen X … Song G (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 3
  5. MicroRNA miR-513a-3p acts as a co-regulator of luteinizing hormone/chorionic gonadotropin receptor gene expression in human granulosa cells. (PMID: 24747085) Troppmann B … Gromoll J (Molecular and cellular endocrinology 2014) 3

Products for MIR513A1 Gene

Sources for MIR513A1 Gene