microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR512-2 Gene

Data sources for MIR512-2 Gene:

RNA type for MIR512-2 Gene

miRNA

Aliases for MIR512-2 Gene

External Ids for MIR512-2 Gene

Previous HGNC Symbols for MIR512-2 Gene

  • MIRN512-2

Previous GeneCards Identifiers for MIR512-2 Gene

  • GC19P058865
  • GC19P054172
  • GC19P053672
  • GC19P053677
  • GC19P053976
  • GC19P054010
  • GC19P054034
  • GC19P054093
  • GC19P053684
  • GC19P053710
  • GC19P053728
  • GC19P053766
  • GC19P053840
  • GC19P053885
  • GC19P053921
  • GC19P053949
  • GC19P054611
  • GC19P055560

Summaries for MIR512-2 Gene

Entrez Gene Summary for MIR512-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR512-2 Gene

MIR512-2 (MicroRNA 512-2) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR512-2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR512-2 Gene

Genomics for MIR512-2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR512-2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053666 Enhancer 0.5 Ensembl ENCODE dbSUPER 250.7 -0.6 -590 4.5 HSALNG0127433 MIR512-1 MIR512-2 HSALNG0127432 LOC107985342 DPRX NLRP12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR512-2 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR512-2 Gene

Latest Assembly
chr19:53,669,157-53,669,254
(GRCh38/hg38)
Size:
98 bases
Orientation:
Plus strand

Previous Assembly
chr19:54,172,411-54,172,508
(GRCh37/hg19 by Entrez Gene)
Size:
98 bases
Orientation:
Plus strand

chr19:54,172,411-54,172,508
(GRCh37/hg19 by Ensembl)
Size:
98 bases
Orientation:
Plus strand

Genomic View for MIR512-2 Gene

Genes around MIR512-2 on UCSC Golden Path with GeneCards custom track
MIR512-2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR512-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR512-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR512-2 Gene

Proteins for MIR512-2 Gene

Post-translational modifications for MIR512-2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR512-2 Gene

Domains & Families for MIR512-2 Gene

Gene Families for MIR512-2 Gene

genes like me logo Genes that share domains with MIR512-2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR512-2 Gene

Function for MIR512-2 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR512-2 Gene

Localization for MIR512-2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR512-2 Gene

Pathways & Interactions for MIR512-2 Gene

PathCards logo

SuperPathways for MIR512-2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR512-2 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR512-2 Gene

Drugs & Compounds for MIR512-2 Gene

No Compound Related Data Available

Transcripts for MIR512-2 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR512-2 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000020F110_9606 miRNA 22 6

RefSeq: NR_030180, NR_030181,

LncBase: hsa-miR-512-3p,

miRBase: MIMAT0002823,

MirGeneDB: Hsa-Mir-430-P8a_3p, Hsa-Mir-430-P8b_3p,

TarBase: hsa-miR-512-3p,

ENA: AY882301.1:1..22:ncRNA, LM379779.1:1..22:ncRNA, LM609470.1:51..72:ncRNA, LM609471.1:57..78:ncRNA,

URS0000062B37_9606 miRNA 23 5

RefSeq: NR_030180, NR_030181,

LncBase: hsa-miR-512-5p,

miRBase: MIMAT0002822,

TarBase: hsa-miR-512-5p,

ENA: AY882302.1:1..23:ncRNA, LM609470.1:14..36:ncRNA, LM609471.1:20..42:ncRNA,

URS000075A8E9_9606 pre_miRNA 98 4

RefSeq: NR_030181,

Ensembl: ENST00000384912 (view in UCSC) ,

miRBase: MI0003141,

ENA: LM609471.1:1..98:precursor_RNA,

URS0000EFF45D_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-430-P8a,

URS0000EFD4D1_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-430-P8a_5p, Hsa-Mir-430-P8b_5p,

MIR512-2 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR512-2 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR512-2 Gene

No ASD Table

Relevant External Links for MIR512-2 Gene

GeneLoc Exon Structure for
MIR512-2

Expression for MIR512-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR512-2 Gene

genes like me logo Genes that share expression patterns with MIR512-2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR512-2 Gene

Orthologs for MIR512-2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR512-2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 30
  • 96 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia -- 30
  • 22 (a)
OneToMany
Species where no ortholog for MIR512-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR512-2 Gene

ENSEMBL:
Gene Tree for MIR512-2 (if available)
TreeFam:
Gene Tree for MIR512-2 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR512-2

Paralogs for MIR512-2 Gene

No data available for Paralogs for MIR512-2 Gene

Variants for MIR512-2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR512-2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR512-2 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
esv5886 CNV loss 19470904
nsv1055718 CNV gain 25217958
nsv580107 CNV gain 21841781

Additional Variant Information for MIR512-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR512-2
Leiden Open Variation Database (LOVD)
MIR512-2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR512-2 Gene

Disorders for MIR512-2 Gene

Additional Disease Information for MIR512-2

No disorders were found for MIR512-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR512-2 Gene

Publications for MIR512-2 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3
  2. Inhibition of c-FLIP expression by miR-512-3p contributes to taxol-induced apoptosis in hepatocellular carcinoma cells. (PMID: 20372864) Chen F … Chen Z (Oncology reports 2010) 3
  3. Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. (PMID: 19503096) Saito Y … Hibi T (Oncogene 2009) 3
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3

Products for MIR512-2 Gene

Sources for MIR512-2 Gene