microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR512-1 Gene

Data sources for MIR512-1 Gene:

RNA type for MIR512-1 Gene


Aliases for MIR512-1 Gene

External Ids for MIR512-1 Gene

Previous HGNC Symbols for MIR512-1 Gene

  • MIRN512-1

Previous GeneCards Identifiers for MIR512-1 Gene

  • GC19P058862
  • GC19P054169
  • GC19P053669
  • GC19P053973
  • GC19P054009
  • GC19P054033
  • GC19P054092
  • GC19P053693
  • GC19P053724
  • GC19P053764
  • GC19P053830
  • GC19P053882
  • GC19P053920
  • GC19P053948
  • GC19P054610
  • GC19P055559

Summaries for MIR512-1 Gene

Entrez Gene Summary for MIR512-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR512-1 Gene

MIR512-1 (MicroRNA 512-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR512-1 include Asymptomatic Dengue and Gastric Cancer.

Additional gene information for MIR512-1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR512-1 Gene

Genomics for MIR512-1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR512-1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J053664 Enhancer 0.6 FANTOM5 Ensembl ENCODE 250.7 -1.7 -1740 0.3 POLR2A HSALNG0127432 MIR512-1 ENSG00000269873 DPRX ZNF813 ZNF765 ZNF761 LOC100288093 LOC107985342 NLRP12
GH19J053666 Enhancer 0.5 Ensembl ENCODE dbSUPER 250.7 +1.9 1888 4.5 HSALNG0127433 MIR512-1 MIR512-2 HSALNG0127432 LOC107985342 DPRX NLRP12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR512-1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR512-1 Gene

Latest Assembly
84 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
84 bases
Plus strand

(GRCh37/hg19 by Ensembl)
98 bases
Plus strand

Genomic View for MIR512-1 Gene

Genes around MIR512-1 on UCSC Golden Path with GeneCards custom track
MIR512-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR512-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR512-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR512-1 Gene

Proteins for MIR512-1 Gene

Post-translational modifications for MIR512-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR512-1 Gene

Domains & Families for MIR512-1 Gene

Gene Families for MIR512-1 Gene

genes like me logo Genes that share domains with MIR512-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR512-1 Gene

Function for MIR512-1 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR512-1 Gene

Localization for MIR512-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR512-1 Gene

Pathways & Interactions for MIR512-1 Gene

PathCards logo

SuperPathways for MIR512-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR512-1 Gene


No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR512-1 Gene

Drugs & Compounds for MIR512-1 Gene

No Compound Related Data Available

Transcripts for MIR512-1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR512-1 Gene

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000020F110_9606 miRNA 22 6

RefSeq: NR_030180, NR_030181,

LncBase: hsa-miR-512-3p,

miRBase: MIMAT0002823,

MirGeneDB: Hsa-Mir-430-P8a_3p, Hsa-Mir-430-P8b_3p,

TarBase: hsa-miR-512-3p,

ENA: AY882301.1:1..22:ncRNA, LM379779.1:1..22:ncRNA, LM609470.1:51..72:ncRNA, LM609471.1:57..78:ncRNA,

URS0000062B37_9606 miRNA 23 5

RefSeq: NR_030180, NR_030181,

LncBase: hsa-miR-512-5p,

miRBase: MIMAT0002822,

TarBase: hsa-miR-512-5p,

ENA: AY882302.1:1..23:ncRNA, LM609470.1:14..36:ncRNA, LM609471.1:20..42:ncRNA,

URS000075DF19_9606 pre_miRNA 84 4

RefSeq: NR_030180,

Ensembl: ENST00000384913 (view in UCSC) ,

miRBase: MI0003140,

ENA: LM609470.1:1..84:precursor_RNA,

URS0000EFD23A_9606 precursor_RNA 59 1

MirGeneDB: Hsa-Mir-430-P8b,

URS0000EFD4D1_9606 miRNA 22 1

MirGeneDB: Hsa-Mir-430-P8a_5p, Hsa-Mir-430-P8b_5p,

MIR512-1 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MIR512-1 Gene

3 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR512-1 Gene

No ASD Table

Relevant External Links for MIR512-1 Gene

GeneLoc Exon Structure for

Expression for MIR512-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR512-1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIR512-1

genes like me logo Genes that share expression patterns with MIR512-1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR512-1 Gene

Orthologs for MIR512-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR512-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 30
  • 96 (a)
(Canis familiaris)
Mammalia -- 30
  • 22 (a)
Species where no ortholog for MIR512-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MIR512-1 Gene

Gene Tree for MIR512-1 (if available)
Gene Tree for MIR512-1 (if available)
Alliance of Genome Resources:
Additional Orthologs for MIR512-1

Paralogs for MIR512-1 Gene

No data available for Paralogs for MIR512-1 Gene

Variants for MIR512-1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR512-1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR512-1 Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV deletion 23290073
esv2762049 CNV gain 21179565
esv5886 CNV loss 19470904
nsv1055718 CNV gain 25217958
nsv580107 CNV gain 21841781

Additional Variant Information for MIR512-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR512-1 Gene

Disorders for MIR512-1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for MIR512-1 Gene - From: MID and COP

Disorder Aliases PubMed IDs
asymptomatic dengue
gastric cancer
  • gastric cancer, somatic
alcoholic cardiomyopathy
  • alcohol-induced heart muscle disease
western equine encephalitis
  • wee
extragonadal nonseminomatous germ cell tumor
  • primary malignant extragonadal nonseminoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR512-1

genes like me logo Genes that share disorders with MIR512-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR512-1 Gene

Publications for MIR512-1 Gene

  1. Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. (PMID: 19503096) Saito Y … Hibi T (Oncogene 2009) 3 72
  2. Long non-coding RNA AFAP1-AS1 promotes proliferation and invasion in prostate cancer via targeting miR-512-3p. (PMID: 31669642) Wang K … Hu B (Gene 2020) 3
  3. Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development. (PMID: 29196869) Martinez-Fierro ML … Ortiz-Castro Y (Archives of gynecology and obstetrics 2018) 3
  4. Reduced miR-512 and the Elevated Expression of Its Targets cFLIP and MCL1 Localize to Neurons With Hyperphosphorylated Tau Protein in Alzheimer Disease. (PMID: 26258756) Mezache L … Nuovo GJ (Applied immunohistochemistry & molecular morphology : AIMM 2015) 3
  5. miR-512-5p suppresses tumor growth by targeting hTERT in telomerase positive head and neck squamous cell carcinoma in vitro and in vivo. (PMID: 26258591) Li J … Tao ZZ (PloS one 2015) 3

Products for MIR512-1 Gene

Sources for MIR512-1 Gene