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microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
MIR5100 (MicroRNA 5100) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR5100 include Childhood Acute Lymphocytic Leukemia and Adult Medulloblastoma.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH10J043000 | Enhancer | 0.4 | Ensembl | 0.7 | +3.4 | 3438 | 0.8 | ZIC2 GLIS1 MYC MAX | ENSG00000259869 MIR5100 piR-32214-054 RET BMS1 | |
GH10J043011 | Enhancer | 0.6 | Ensembl ENCODE | 0.4 | +15.0 | 15005 | 2.1 | GATA3 NANOG SP1 SPI1 | ZNF33B LINC00839 piR-32214-054 MIR5100 RET BMS1 | |
GH10J043018 | Enhancer | 0.2 | Ensembl | 0.4 | +21.9 | 21883 | 0.9 | piR-32214-054 ENSG00000259869 MIR5100 RET BMS1 |
RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
---|---|---|---|---|
URS000075DAD1_9606 | precursor_RNA | 119 | 5 |
HGNC: 43540, RefSeq: NR_049836, Ensembl: ENST00000579544 (view in UCSC) , miRBase: MI0019116, |
URS0000079F78_9606 | miRNA | 22 | 5 |
RefSeq: NR_049836, LncBase: hsa-miR-5100, miRBase: MIMAT0022259, TarBase: hsa-miR-5100, |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2759746 | CNV | loss | 17122850 |
nsv1038102 | CNV | gain | 25217958 |
nsv1042764 | CNV | gain | 25217958 |
nsv550695 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
childhood acute lymphocytic leukemia |
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adult medulloblastoma |
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