microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR5100 Gene

Data sources for MIR5100 Gene:

Subcategory (RNA class) for MIR5100 Gene

miRNA

Aliases for MIR5100 Gene

External Ids for MIR5100 Gene

Previous GeneCards Identifiers for MIR5100 Gene

  • GC10U901583
  • GC10P043495

Summaries for MIR5100 Gene

Entrez Gene Summary for MIR5100 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR5100 Gene

MIR5100 (MicroRNA 5100) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR5100 include Childhood Acute Lymphocytic Leukemia and Adult Medulloblastoma.

Additional gene information for MIR5100 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR5100 Gene

Genomics for MIR5100 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MIR5100 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J043000 Enhancer 0.4 Ensembl 0.7 +3.4 3438 0.8 ZIC2 MYC MAX GLIS1 ENSG00000259869 MIR5100 piR-32214-054 lnc-RET-3 LINC01264 RET BMS1
GH10J043011 Enhancer 0.6 Ensembl ENCODE 0.4 +15.0 15005 2.1 SP1 SPI1 NANOG ZNF33B LINC00839 piR-32214-054 MIR5100 LINC01264 RET lnc-RET-3 BMS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIR5100 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for MIR5100 Gene

Latest Assembly
chr10:42,997,563-42,997,681
(GRCh38/hg38)
Size:
119 bases
Orientation:
Plus strand

Previous Assembly
chr10:43,493,011-43,493,129
(GRCh37/hg19 by Entrez Gene)
Size:
119 bases
Orientation:
Plus strand

chr10:43,493,011-43,493,129
(GRCh37/hg19 by Ensembl)
Size:
119 bases
Orientation:
Plus strand

Genomic View for MIR5100 Gene

Genes around MIR5100 on UCSC Golden Path with GeneCards custom track
MIR5100 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MIR5100 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR5100 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR5100 Gene

Proteins for MIR5100 Gene

Post-translational modifications for MIR5100 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR5100 Gene

Domains & Families for MIR5100 Gene

Gene Families for MIR5100 Gene

HGNC:
genes like me logo Genes that share domains with MIR5100: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR5100 Gene

Function for MIR5100 Gene

Phenotypes From GWAS Catalog for MIR5100 Gene

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR5100 Gene

Localization for MIR5100 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR5100 gene
Compartment Confidence
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR5100 Gene

Pathways & Interactions for MIR5100 Gene

PathCards logo

SuperPathways for MIR5100 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR5100 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR5100 Gene

Drugs & Compounds for MIR5100 Gene

No Compound Related Data Available

Transcripts for MIR5100 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for MIR5100 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS0000079F78_9606 miRNA 22 5

RefSeq: NR_049836,

LncBase: hsa-miR-5100,

miRBase: MIMAT0022259,

TarBase: hsa-miR-5100,

ENA: LM382952.1:1..22:ncRNA, LM611567.1:68..89:ncRNA,

URS000075DAD1_9606 precursor_RNA 119 4

RefSeq: NR_049836,

Ensembl: ENST00000579544 (view in UCSC) ,

miRBase: MI0019116,

ENA: LM611567.1:1..119:precursor_RNA,

MIR5100 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Alternative Splicing Database (ASD) splice patterns (SP) for MIR5100 Gene

No ASD Table

Relevant External Links for MIR5100 Gene

GeneLoc Exon Structure for
MIR5100

No data available for mRNA/cDNA for MIR5100 Gene

Expression for MIR5100 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR5100 Gene

genes like me logo Genes that share expression patterns with MIR5100: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR5100 Gene

Orthologs for MIR5100 Gene

Evolution for MIR5100 Gene

ENSEMBL:
Gene Tree for MIR5100 (if available)
TreeFam:
Gene Tree for MIR5100 (if available)

No data available for Orthologs for MIR5100 Gene

Paralogs for MIR5100 Gene

No data available for Paralogs for MIR5100 Gene

Variants for MIR5100 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MIR5100 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MIR5100 Gene

Variant ID Type Subtype PubMed ID
esv2759746 CNV loss 17122850
nsv1038102 CNV gain 25217958
nsv1042764 CNV gain 25217958
nsv550695 CNV gain 21841781

Additional Variant Information for MIR5100 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR5100

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR5100 Gene

Disorders for MIR5100 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MIR5100 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
childhood acute lymphocytic leukemia
  • childhood acute lymphoblastic leukemia
adult medulloblastoma
  • adult brain medulloblastoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR5100

genes like me logo Genes that share disorders with MIR5100: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR5100 Gene

Publications for MIR5100 Gene

  1. Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT. (PMID: 30866952) Zhang X … Xiang J (Molecular cancer 2019) 3
  2. Serum miRNA-371b-5p and miRNA-5100 act as biomarkers for systemic lupus erythematosus. (PMID: 30304699) Zeng L … Lu QJ (Clinical immunology (Orlando, Fla.) 2018) 3
  3. MiR-5100 increases the cisplatin resistance of the lung cancer stem cells by inhibiting the Rab6. (PMID: 29144562) Yang L … Liu G (Molecular carcinogenesis 2018) 3
  4. [Association between expression of plasma miRNA and the risk of childhood acute lymphocytic leukemia]. (PMID: 28910942) Yuan DM … Ke YB (Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2017) 3
  5. Increasing expression of miR-5100 in non-small-cell lung cancer and correlation with prognosis. (PMID: 28925485) Wang T … Chang P (European review for medical and pharmacological sciences 2017) 3

Products for MIR5100 Gene

Sources for MIR5100 Gene