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Aliases for MIR508 Gene

Subcategory (RNA class) for MIR508 Gene


Quality Score for this RNA gene is


Aliases for MIR508 Gene

  • MicroRNA 508 2 3 5
  • Hsa-Mir-508 3
  • MIRN508 3

External Ids for MIR508 Gene

Previous HGNC Symbols for MIR508 Gene

  • MIRN508

Previous GeneCards Identifiers for MIR508 Gene

  • GC0XM146127
  • GC0XM146318

Summaries for MIR508 Gene

Entrez Gene Summary for MIR508 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR508 Gene

MIR508 (MicroRNA 508) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR508 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR508 Gene

Genomics for MIR508 Gene

Genomic Locations for MIR508 Gene

Genomic Locations for MIR508 Gene
115 bases
Minus strand

Genomic View for MIR508 Gene

Genes around MIR508 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR508 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR508 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR508 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR508 Gene

Proteins for MIR508 Gene

Post-translational modifications for MIR508 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR508 Gene

Domains & Families for MIR508 Gene

Gene Families for MIR508 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR508: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR508 Gene

Function for MIR508 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR508 Gene

Localization for MIR508 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR508 Gene

Pathways & Interactions for MIR508 Gene

SuperPathways for MIR508 Gene

No Data Available

Interacting Proteins for MIR508 Gene

Gene Ontology (GO) - Biological Process for MIR508 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR508 Gene

Drugs & Compounds for MIR508 Gene

No Compound Related Data Available

Transcripts for MIR508 Gene

mRNA/cDNA for MIR508 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR508 Gene

No ASD Table

Relevant External Links for MIR508 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR508 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR508 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR508 Gene:

genes like me logo Genes that share expression patterns with MIR508: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR508 Gene

Orthologs for MIR508 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR508 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-508 34
  • 89 (a)
(Bos Taurus)
Mammalia -- 34
  • 71 (a)
Species where no ortholog for MIR508 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR508 Gene

Gene Tree for MIR508 (if available)
Gene Tree for MIR508 (if available)

Paralogs for MIR508 Gene

No data available for Paralogs for MIR508 Gene

Variants for MIR508 Gene

Sequence variations from dbSNP and Humsavar for MIR508 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002769315 -- 147,236,541(-) G/A downstream_transcript_variant
rs1006051059 -- 147,236,985(-) G/A non_coding_transcript_variant
rs1006082003 -- 147,236,601(-) T/C downstream_transcript_variant
rs1011755039 -- 147,237,561(-) A/C upstream_transcript_variant
rs1013118027 -- 147,238,559(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR508 Gene

Variant ID Type Subtype PubMed ID
esv2758898 CNV gain 17122850
esv35128 CNV gain 17911159
nsv508808 CNV insertion 20534489
nsv521982 CNV gain 19592680
nsv522829 CNV gain 19592680

Additional Variant Information for MIR508 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR508 Gene

Disorders for MIR508 Gene

Additional Disease Information for MIR508

No disorders were found for MIR508 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR508 Gene

Publications for MIR508 Gene

  1. MiR-508-5p is a prognostic marker and inhibits cell proliferation and migration in glioma. (PMID: 28121353) Liu YH … Qiu L (European review for medical and pharmacological sciences 2017) 3 58
  2. The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer. (PMID: 26623719) Shang Y … Fan D (Oncotarget 2016) 3 58
  3. miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis. (PMID: 26801246) Huang T … To KF (Molecular cancer 2016) 3 58
  4. MiR-508-5p Inhibits the Progression of Glioma by Targeting Glycoprotein Non-metastatic Melanoma B. (PMID: 27003587) Bao G … He B (Neurochemical research 2016) 3 58
  5. miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1. (PMID: 23893241) Shang Y … Fan D (Oncogene 2014) 3 58

Products for MIR508 Gene

Sources for MIR508 Gene

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