microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The ... See more...

Aliases for MIR506 Gene

Subcategory (RNA class) for MIR506 Gene


Number of RNA Genes sources:

4 / 14

Aliases for MIR506 Gene

  • MicroRNA 506 2 3 5
  • Hsa-MiR-506-3p 166 177
  • MIMAT0022701 51
  • MIMAT0002878 51
  • Hsa-Mir-506 3
  • MI0003193 51
  • Mir-506 3
  • MIRN506 3
  • MIR506 2

External Ids for MIR506 Gene

Previous HGNC Symbols for MIR506 Gene

  • MIRN506

Previous GeneCards Identifiers for MIR506 Gene

  • GC0XM146121
  • GC0XM146312

Summaries for MIR506 Gene

Entrez Gene Summary for MIR506 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR506 Gene

MIR506 (MicroRNA 506) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR506 include Ovarian Cancer.

Additional gene information for MIR506 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIR506 Gene

Genomics for MIR506 Gene

Genomic Locations for MIR506 Gene

Genomic Locations for MIR506 Gene
124 bases
Minus strand
124 bases
Minus strand

Genomic View for MIR506 Gene

Genes around MIR506 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR506 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR506 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR506 Gene

No data available for GeneHancer (GH) Regulatory Elements for MIR506 Gene

Proteins for MIR506 Gene

Post-translational modifications for MIR506 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR506 Gene

Domains & Families for MIR506 Gene

Gene Families for MIR506 Gene

genes like me logo Genes that share domains with MIR506: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIR506 Gene

Function for MIR506 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR506 Gene

Localization for MIR506 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIR506 gene
Compartment Confidence
plasma membrane 2
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR506 Gene

Pathways & Interactions for MIR506 Gene

PathCards logo

SuperPathways for MIR506 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR506 Gene


No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for MIR506 Gene

Drugs & Compounds for MIR506 Gene

No Compound Related Data Available

Transcripts for MIR506 Gene

mRNA/cDNA for MIR506 Gene

4 RNACentral transcripts :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
3 miRBase transcripts :
6 ENA transcripts :
1 LncBase transcripts :
1 TarBase transcripts :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR506 Gene

No ASD Table

Relevant External Links for MIR506 Gene

GeneLoc Exon Structure for

Expression for MIR506 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR506 Gene

genes like me logo Genes that share expression patterns with MIR506: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR506 Gene

Orthologs for MIR506 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR506 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-506 31
  • 100 (a)
Species where no ortholog for MIR506 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR506 Gene

Gene Tree for MIR506 (if available)
Gene Tree for MIR506 (if available)

Paralogs for MIR506 Gene

No data available for Paralogs for MIR506 Gene

Variants for MIR506 Gene

Additional dbSNP identifiers (rs#s) for MIR506 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR506 Gene

Variant ID Type Subtype PubMed ID
esv2758898 CNV gain 17122850
esv35128 CNV gain 17911159
nsv521982 CNV gain 19592680
nsv522829 CNV gain 19592680

Additional Variant Information for MIR506 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for MIR506 Gene

Disorders for MIR506 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR506 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • ovarian cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR506

genes like me logo Genes that share disorders with MIR506: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR506 Gene

Publications for MIR506 Gene

  1. MicroRNA-506 inhibits the proliferation and invasion of mantle cell lymphoma cells by targeting B7H3. (PMID: 30553455) Zhu XW … Ke XY (Biochemical and biophysical research communications 2019) 3 54
  2. MicroRNA-506 inhibits tumor growth and metastasis in nasopharyngeal carcinoma through the inactivation of the Wnt/β-catenin signaling pathway by down-regulating LHX2. (PMID: 30791932) Liang TS … Liu ZS (Journal of experimental & clinical cancer research : CR 2019) 3 54
  3. MicroRNA-506-3p initiates mesenchymal-to-epithelial transition and suppresses autophagy in osteosarcoma cells by directly targeting SPHK1. (PMID: 30669957) Wang D … Li J (Bioscience, biotechnology, and biochemistry 2019) 3 54
  4. MicroRNA‑506‑3p reverses gefitinib resistance in non‑small cell lung cancer by targeting Yes‑associated protein 1. (PMID: 30535506) Zhu J … Jin L (Molecular medicine reports 2019) 3 54
  5. MiR-506 Promotes Natural Killer Cell Cytotoxicity against Human Hepatocellular Carcinoma Cells by Targeting STAT3. (PMID: 30554487) Su Z … Shang L (Yonsei medical journal 2019) 3 54

Products for MIR506 Gene

Sources for MIR506 Gene